Elsevier

Neuropharmacology

Volume 14, Issue 11, November 1975, Pages 827-834
Neuropharmacology

Attenuation of amphetamine anorexia by unilateral nigral striatal lesions

https://doi.org/10.1016/0028-3908(75)90110-0Get rights and content

Abstract

Rats with unilateral lateral hypothalamic lesions, which destroyed the nigral striatal bundle, exhibited an attenuation of the food intake suppressive effect of (+)-amphetamine. Rats with unilateral medial hypothalamic lesions, however, did not differ significantly from intact controls in terms of responsivity to the anorexic effect of amphetamine. In a second experiment, unilateral substantia nigra lesions attenuated the anorexic effect of amphetamine to an extent comparable with the unilateral lateral hypothalamic lesion. Both the substantia nigra and unilateral lateral hypothalamic lesion severely depleted dopamine and to a lesser extent norepinephrine on the damaged half of the brain. Thus, unilateral falls in brain catecholamines can reduce the anorexic efficacy of amphetamine.

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