Reduced hippocampal CA1 Ca2+-induced long-term potentiation is associated with age-dependent impairment of spatial learning
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Cited by (39)
Age-dependent changes in autophosphorylation of alpha calcium/calmodulin dependent kinase II in hippocampus and amygdala after contextual fear conditioning
2017, Brain Research BulletinCitation Excerpt :Aging impairs contextual fear and spatial memory (Murphy et al., 2004; Peters et al., 2014). A possible explanation for this deterioration may come from age-related difficulties in activating NMDA receptors, raising the threshold for NMDA receptor-dependent LTP induction (Murphy et al., 2004; Bonhaus et al., 1990; Kumar, 2015; Deupree et al., 1993; Moore et al., 1993; Diana et al., 1995; Barnes et al., 1996; Kumar et al., 2007). Furthermore, aging encourages NMDA receptor-independent methods for LTP induction using VGCC channels in the hippocampus (Boric et al., 2008).
Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl-D-aspartate receptors and voltage-dependent Ca<sup>2+</sup> channels in senescent synaptic plasticity
2012, Progress in NeurobiologyCitation Excerpt :We have noted that memory consolidation deficits could explain the characteristic “saw-toothed” pattern of behavior observed for aged rats (Foster, 1999). In this case, older rats exhibit improved performance across trials within a day and impairments are observed for the first trial on the following day (Aitken and Meaney, 1989; Diana et al., 1995; Driscoll et al., 2006; Gage et al., 1984; Mabry et al., 1996; Rapp et al., 1987). This pattern has also been reported to emerge in middle-age (12 month) Long-Evans rats (Aitken and Meaney, 1989), and a similar pattern may be observed for aged male mice (Benice et al., 2006).
TrkB but not trkC receptors are necessary for postnatal maintenance of hippocampal spines
2008, Neurobiology of AgingCitation Excerpt :Similarly, trkC, which is uniformly expressed in both pyramidal and non-pyramidal neurons in the human hippocampus throughout postnatal life, has been reported to decline during aging (Beltaifa et al., 2005). Interestingly, aging does not imply a loss of hippocampal neurons (von Bohlen und Halbach and Unsicker, 2002), despite a significant decline in hippocampus-related spatial memory (von Bohlen und Halbach et al., 2006b) and an age-dependent impairment of hippocampal LTP and spatial learning (Diana et al., 1995). However, these alterations are paralleled by significant reductions in spine densities in the hippocampal formation during normal aging (Nunzi et al., 1987; von Bohlen und Halbach et al., 2006b).
Susceptibility to induction of long-term depression is associated with impaired memory in aged Fischer 344 rats
2007, Neurobiology of Learning and MemoryAge-related disturbance of memory and CREB phosphorylation in CA1 area of hippocampus of rats
2005, Brain ResearchCitation Excerpt :One of the mechanisms is a reduction in the duration of experimentally induced long-term potentiation (LTP) of hippocampal synapses [16,17], which is correlated with faster forgetting of spatial information [4]. The impairment of LTP was thought to be caused by an increase of intracellular calcium by aging [6,17]. Another is loss of synaptic connectivity and integration among hippocampal cells, which can lead to a reduced probability or magnitude of LTP induction [6,7,15,21].