Male preference for the odors of estrous female mice is enhanced by the neurosteroid 3α-hydroxy-4-pregnen-20-one (3αHP)
Reference (34)
- et al.
Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor
Brain Res.
(1991) - et al.
Anxiolytic effect of progesterone is associated with increases in cortical allopregnanolone and GABAA receptor function
Pharmacol. Biochem. Behav.
(1993) - et al.
Anxiolytic activity of an endogenous adrenal steroid
Brain Res.
(1986) Progesterone-facilitated sexual receptivity: a review of arguements supporting a non-genomic mechanism
Neurosci. Biobehav. Rev.
(1991)- et al.
The relationship between the physiological condition of the female mice and the effects of their urine on the social behaviour of adult males
Anim. Behav.
(1975) - et al.
Comparative effects of progesterone and alphaxalone on aggressive, reproductive and locomotor behaviors
Pharmacol. Biochem. Behav.
(1988) - et al.
3α-OH-DHP and 5α-THDOC implants to the ventral tegmental area facilitate sexual receptivity in hamsters after progesterone priming to the ventral medial hypothalamus
Brain Res.
(1993) - et al.
γ-Aminobutyric acid-dependent modulation of the chloride ionophore by steroids in rat brain
Eur. J. Pharmacol.
(1987) - et al.
Sex-attractant emitted by female mice
Physiol. Behav.
(1974) - et al.
Analgesic effects of the progesterone metabolite, 3α-hydroxy-5α-pregnan-20-one, and possible modes of action in mice
Brain Res.
(1987)
Reduction predator odor-induced anxiety in mice by the neurosteroid 3α-hydroxy-4-pregnen-20-one (3αHP)
Brain Res.
The stimulation of central κ opioid receptors decreases male sexual behavior and activity
Brain Res.
Steroid hormone metabolites potentiate GABA-mediated chloride ion flux with nanomolar potency
Eur. J. Pharmacol.
Differential antagonism by epipregnanolonne and pregnanolone potentiation of [3H]flunitrazepam binding suggests more than one class of binding sites for steroids at GABAA receptors
Neuropharmacology
Synthesis of the allylic gonadal steroids, 3α-hydroxy-4-pregnen-20-one and 3α-hydroxy-4-androgen-17-one, and of 3α-hydroxy-5α-pregnan-20-one
Steroids
Analgesic effects of the putative FSH-suppressing gonadal steroid, 3α-hydroxy-4-pregnen-20-one: possible modes of action
Brain Res.
Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one
Brain Res.
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2015, Hormones and BehaviorCitation Excerpt :The changes in the attractiveness of a sender's scent mark appear to be concomitant with changes in the responses of receivers to such marks (Ferkin, 2011; Johnston, 2008; Roberts, 2007). The scent marks of female house mice and golden hamsters may only be attractive to male conspecifics when the female is in estrus (delBarco-Trillo et al., 2009; Johnston, 1983; Kavaliers et al., 1994). Interestingly, male house mice that had their vomeronasal organs removed no longer maintained a preference for the urine marks of a female house mouse that was in estrus (Pankevich et al., 2004).
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This research was supported by Agriculture Canada and Natural Science and Engineering Research Council of Canada grants to M.K. and J.P.W.
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We thank Terry Seely and Joan Ingoldsby for their assistance.