Opioids act at μ-receptors to hyperpolarize arcuate neurons via an inwardly rectifying potassium conductance
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Cited by (73)
Activation of mu-opioid receptors in the ventrolateral orbital cortex inhibits the GABAergic miniature inhibitory postsynaptic currents in rats
2015, Neuroscience LettersCitation Excerpt :It indicated that these mIPSCs were mediated by GABAA receptors, namely as GABAergic mIPSCs. Application of DAMGO, a selective mu-opioid receptor agonist (5.0 μM) [2,14,18] into the VLO slice, inhibited the GABAergic mIPSCs frequency, without affecting the amplitude distribution of the mIPSCs (76.9%, 20 of 26 neurons). In the remaining 6 neurons, DAMGO did not significantly alter the frequency or amplitude of mIPSCs.
Opioid-mediated regulation of A11 diencephalospinal dopamine neurons: Pharmacological evidence of activation by morphine
2011, NeuropharmacologyCitation Excerpt :As there are well-documented sex differences in the basal activity of DA neurons terminating in the median eminence (Lookingland and Moore, 2005), a sex-specific effect of morphine is to be expected. Endogenous β-endorphins are inhibitory to A12 tuberoinfundibular DA neurons terminating in the median eminence (Haskins et al., 1981; Lookingland and Moore, 1985; Loose and Kelly, 1990; Callahan et al., 1996; Andrews and Grattan, 2003; Tavakoli-Nezhad and Arbogast, 2010), but not under normal, basal conditions (Deyo et al., 1979). A delayed activation of A12 DA neurons 4 h after morphine has been observed, as evidenced by increased DA turnover in the median eminence and increased DA concentrations in the pituitary portal blood (Gudelsky et al., 1986).
Potential role of female sex hormones in the pathophysiology of migraine
2007, Pharmacology and Therapeuticsβ-endorphin alters electrical activity of gonadotropin releasing hormone neurons located in the terminal nerve of the teleost medaka (Oryzias latipes)
2007, General and Comparative EndocrinologyCitation Excerpt :Work in mammals show that opioids acting at μ, δ, and κ receptors hyperpolarize membrane potential by increasing K+ conductances, typically an inwardly rectifying K+ conductance (North et al., 1987; Grudt and Williams, 1993; Svoboda and Lupica, 1998; Chen et al., 2001). This is also true for hypothalamic neurons in general, and hypothalamic GnRH neurons in particular (Lagrange et al., 1995; Loose and Kelly, 1990). This hyperpolarization would lead to decreased probability of firing action potentials and decreased transmitter/peptide release.
Chapter VIII Functional neuroanatomy of hypothalamic dopaminergic neuroendocrine systems
2005, Handbook of Chemical Neuroanatomy