Research reportQuantitative evaluation of the properties of a pyridazinyl GABA derivative (SR 95531) as a GABAA competitive antaginist. An electrophysiological approach
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Developmental exposure to PCBs alters the activation of the auditory cortex in response to GABA<inf>A</inf> antagonism
2016, NeuroToxicologyCitation Excerpt :This concentration of AP5 has been previously used in examining flavoprotein autofluorescence in mouse slices (Llano et al., 2012). The concentration of SR95531 used for the experiments was based on previous experiments showing that the dissociation constant of this drug is around 170 nM for neurons (Hamann et al., 1988). For each stimulation intensity, a total of 420 images were collected with the image size of 172 × 130 pixels (8 × 8 binning).
Population patch-clamp electrophysiology analysis of recombinant GABA <inf>a</inf> α1βeγ2 channels expressed in HEK-293 cells
2009, Journal of Biomolecular ScreeningDissociation constants for GABA<inf>A</inf> receptor antagonists determined with neuronal networks on microelectrode arrays
2008, Journal of Neuroscience MethodsDifferential effects of iontophoretic application of the GABA<inf>A</inf>-antagonists bicuculline and gabazine on tone-evoked local field potentials in primary auditory cortex: Interaction with ketamine anesthesia
2008, Brain ResearchCitation Excerpt :At least some of these secondary effects are thought to result from actions of BIC on calcium-dependent potassium channels (Johansson et al., 2001). In contrast, application of gabazine, although it has a higher affinity for the GABAA-receptor than BIC, never led to observable side effects but only to blocking of GABAA-mediated inhibition (see also Chambon et al., 1985; Heaulme et al., 1986; Hamann et al., 1988). Here we investigated whether the deleterious effects of BIC on pure tone-evoked responses of single and multi-units in AI can also be seen on the population level of cortical activity.
Cerebellar LTD and Pattern Recognition by Purkinje Cells
2007, NeuronCitation Excerpt :CFs were activated with a second ACSF-filled electrode placed in the granule cell layer. GABAA receptors were blocked by bath application of the specific antagonist SR95531 (“SR”) (Hamann et al., 1988), except when otherwise noted. Data were low-pass filtered at 4–10 kHz and sampled at 20 kHz with a 1321A Digidata A/D converter (Axon Instruments).