Putative pain modulating neurons in the rostral ventral medulla: Reflex-related activity predicts effects of morphine
References (33)
- et al.
Analgesia induced by microinjection of morphine into, and electrical stimulation of, the nucleus reticularis paragigantocellularis of rat medulla oblongata
Neuropharmacology
(1978) - et al.
Response of medullary raphe neurons to peripheral stimulation and to systemic opiates
Brain Research
(1977) - et al.
The contribution of neucleus reticularis paragigantocellularis and nucleus raphe magnus to the analgesia produced by sytemically administered morphine investigated with the microinjection technique
Pain
(1982) - et al.
Dissociation of supraspinal and spinal actions of morphine: a quantitative evaluation
Brain Research
(1980) - et al.
Reversal of morphine and stimulus-produced analgesia by subtotal spinal cord lesions
Pain
(1977) - et al.
Role of the nucleus raphe magnus in opiate analgesia as studied by the microinjection technique in the rat
Brain Research
(1979) - et al.
Evidence that raphe-spinal neurons mediate opiate amd midbrain stimulation produced analgesia
Pain
(1978) - et al.
Nucleus raphe magnus inhibition of spinal cord dorsal horn neurons
Brain Research
(1977) Opiate and opioid peptide effects on brainstem neurons: relebance to nociceptor and antinociceptor mechanisms
Pain
(1982)- et al.
Effects induced by stimulation of the centralis inferior nucleus of the raphe on dorsal horn interneurons in cat's spinal cord
Brain Research
(1977)
Analgesia produced by microinjection of baclofen and morphine at brainstem sites
Eur. J. Pharmacol.
(1979)
Time-course of alterations in morphine-induced analgesia and nociceptive threshold following medullary raphe lesions
Neuroscience
(1981)
Morphine analgesia blockade by raphe magnus lesions
Brain Research
(1975)
Characterization of inhibition of a spinal nociceptive reflex by stimulation medially and laterally in the midbrain and medulla in the pentobarbital-anesthetized rat
Brain Research
(1984)
Responses of raphe magnus neurons to systemic morphine in rats
Brain Res. Bull.
(1982)
Studies on the antagonism by raphe lesion of the antinociceptive action of systemic morphine
Eur. J. Pharmacol.
(1977)
Cited by (145)
Endogenous opioid peptides in the descending pain modulatory circuit
2020, NeuropharmacologyCannabinoids in the descending pain modulatory circuit: Role in inflammation
2020, Pharmacology and Therapeutics5.15 - The Brainstem and Nociceptive Modulation
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionActivity correlations between on-like and off-like cells of the rostral ventromedial medulla and simultaneously recorded wide-dynamic-range neurons of the spinal dorsal horn in rats
2016, Brain ResearchCitation Excerpt :Fig. 5B shows the decrease in spike activity of the same neuron pair in 15s-bin histograms during 80 min after morphine microinjection into RVM. This decrease in off-like cell activity induced by morphine during deep barbiturate anesthesia is in contrast with the activation of off-cells when μ-opioid agonists are administered systemically or locally into the RVM to lightly anesthetized rats (Barbaro et al., 1986; Fields et al., 1983b; Heinricher et al., 1994). In spite of such unusual behavior, in the absence of morphine the neurons herein labelled as off-like cells showed a stable behavior and were reliably inhibited by mechanical stimulation of their receptive field (Fig. 6A,B).
Copyright © 1986 Published by Elsevier B.V.