Analgesia elicited by prefrontal stimulation

doi:10.1016/0006-8993(85)90093-9

Brain Research

Volume 339, Issue 2, 29 July 1985, Pages 281-284

https://doi.org/10.1016/0006-8993(85)90093-9 Get rights and content

Abstract

Bipolar stimulating electrodes were placed into the medial prefrontal cortex (PFC) or control sites (occipital or cerebellar cortices) in adult male rats. Subsequently, it was determined that PFC stimulation resulted in a significant elevation of nociceptive response latencies, as tested using hot plate and tail flick techniques. Stimulation in control sites did not produce an increase in these response latencies. Rats receiving PFC stimulation were able to respond normally to various innocuous stimuli. Furthermore, seizures were not observed in these rats. These facts indicated that PFC stimulation did not disorient the animals nor inhibit their voluntary motor activity. The results of this study seem to indicate that the PFC is a site from which stimulus-produced analgesia may be elicited.

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View full text

Analgesia elicited by prefrontal stimulation

Abstract

Neurosci. Lett.

Brain Research

Brain Research

Physiol. Behav.

Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry

Ann. Rev. Neurosci.

Supramedullary afferents of the nucleus raphe magnus in the rat: a study using the transcannula HRP gel and autoradiographic techniques

J. comp. Neurol.

The hippocampus

Prefrontal influences upon periaqueductal gray and adjacent regions

Soc. Neurosci. Abstr.

The effects of morphine, methadone and meperidine on some reflex responses of spinal animals to nociceptive stimulation

J. Pharmacol. exp. Ther.