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Cited by (111)
Neurotoxicity studies with a tropomyosin-related kinase A inhibitor, ASP7962, on the sympathetic and sensory nervous systems in rats
2021, Toxicology LettersCitation Excerpt :The primary test article related effect in these studies was on neuron size. Atrophy of sympathetic ganglion neurons has been reported to occur in association with anti-nerve growth factor states in rodents (Angeletti et al., 1971; Ruit et al., 1990). Increased glial cell density was a secondary effect, as the glial cells were generally more tightly packed due to the reduction in neuron size.
BDNF is required for taste axon regeneration following unilateral chorda tympani nerve section
2017, Experimental NeurologyAnti-NGF monoclonal antibody muMab 911 does not deplete neurons in the superior cervical ganglia of young or old adult rats
2016, Journal of Chemical NeuroanatomyCitation Excerpt :During late embryonic and early postnatal development both sensory and sympathetic neurons require NGF for survival and maturation (Crowley et al., 1994; Smeyne et al., 1994; Glebova and Ginty, 2004). However, while it appears these neurons become independent of NGF as they mature (Kole et al., 2013), there are a number of reports (Angeletti et al., 1971; Gorin and Johnson, 1980; Johnson et al., 1982; Ruit et al., 1990; Hoffman et al., 2011) that suggest NGF is required for survival of neurons in adult animals. Early studies reported that suppression of NGF by polyclonal antisera in adult animals decreased the volume of sympathetic chain ganglia and/or decreased the size of the associated neurons following both acute (Levi-Montalcini and Booker, 1960; Angeletti et al., 1971; Bjerre et al., 1975; Goedert et al., 1978) and chronic (Otten et al., 1979; Gorin and Johnson, 1980; Johnson et al., 1982; Ruit et al., 1990; Ruberti et al., 2000) treatments.
A multiple-dose toxicity study of tanezumab in cynomolgus monkeys
2011, Regulatory Toxicology and PharmacologyCitation Excerpt :Even at exposures well above therapeutic levels for up to 6 months, primates treated with tanezumab did not reveal any significant pharmacologically mediated toxic or adverse effects on any organ systems including the nervous system. Our results contrast with an extensive body of literature describing the adverse effects of NGF anti-serum treatment on sensory and sympathetic ganglia in rodents (Angeletti et al., 1971; Ruit et al., 1990; Schwartz et al., 1982). For example, anti-NGF has been associated with pronounced biochemical and morphological atrophy of the superior cervical ganglion and a reduction in neuronal number in the adult rat (Gorin and Johnson, 1980; Johnson et al., 1989); the disappearance of adrenergic nerve terminals in several peripheral tissues in the adult mouse (Bjerre et al., 1975); and a reduction in the substance P content of sensory ganglia, spinal cord, and hind paw skin in adult rats and guinea pigs (Schwartz et al., 1982).
Extracellular signals regulating sympathetic neuron survival and target innervation during development
2009, Autonomic Neuroscience: Basic and Clinical