Abstract
Protocadherin 11 X-linked (Pcdh11x) protein is a member of the cadherin superfamily with established roles in cell adhesion. Previous studies have shown the molecular biology and possible relevance of Pcdh11x with neurological disease in humans. However, little is known about the neurophysiological function of Pcdh11x in neural development. Here, we verified that Pcdh11x is primarily expressed in various brain areas including the cortex, hippocampus, and ventricular/subventricular zone (VZ/SVZ) at different embryonic stages. Furthermore, both in vitro and in vivo experiments showed that Pcdh11x decreased neural differentiation but increased the neural proliferation. These observations demonstrate a crucial function for Pcdh11x during the development of central nervous system.
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Acknowledgments
This study was funded by Military Medical Project (BWS11J002, BWS12J010) and National Natural Science Foundation (no. 30973096). Thanks to Zhang Xiao Chong at Ju Lu Hospital for her help with the experiment. We thank Elsevier Language Editing (Project no.: 39443) for assisting in the preparation of this manuscript. The authors would like to thank all the anonymous reviewers for their valuable comments on how to improve the quality of this paper.
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No conflicts of interest, financial or otherwise, are declared by the authors.
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Peng Zhang and Cuiying Wu contribute equally to this work.
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Zhang, P., Wu, C., Liu, N. et al. Protocadherin 11 X Regulates Differentiation and Proliferation of Neural Stem Cell In Vitro and In Vivo. J Mol Neurosci 54, 199–210 (2014). https://doi.org/10.1007/s12031-014-0275-x
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DOI: https://doi.org/10.1007/s12031-014-0275-x