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Video Analysis of Sensory-Motor Features in Infants with Fragile X Syndrome at 9–12 Months of Age

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An Erratum to this article was published on 08 December 2006

 

This study utilized retrospective video analysis to distinguish sensory-motor patterns in infants with fragile X syndrome (FXS) (n=11) from other infants [i.e., autism (n=11), other developmental delay (n=10), typical (n=11)] at 9–12 months of age. Measures of development, autistic features, and FMRP were assessed at the time of entry into the study. Home videos collected from families were edited and coded with previously validated procedures. Findings revealed a pattern of sensory-motor features (e.g., repetitive leg movements, posturing, less sophistication/repetitive use of objects) associated with FXS, and suggest these infants were most similar to the group of infants with other developmental delays, irrespective of co-existing autistic symptoms later in life. Infant sensory-motor features in the FXS group were more predictive of an early developmental milestone (i.e., age walking) than later, more broad, developmental outcomes, or FMRP. Implications for early identification and differential diagnosis are discussed.

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References

  • Bailey D. B. Jr., Hatton D. D., Mesibov G., Ament N., Skinner M., (2000). Early development, temperament, and functional impairment in autism and fragile X syndrome Journal of Autism and Developmental Disorders30(1): 49–59

    Article  PubMed  Google Scholar 

  • Bailey D. B. Jr., Hatton D. D., Skinner M., (1998a). Early developmental trajectories of males with fragile X syndrome American Journal of Mental Retardation 103(1): 29–39

    Article  Google Scholar 

  • Bailey D. B. Jr., Hatton D. D., Skinner M., Mesibov G., (2001). Autistic behavior, FMR1 protein, and developmental trajectories in young males with fragile X syndrome Journal of Autism and Developmental Disorders31(2): 165–174

    Article  PubMed  Google Scholar 

  • Bailey D. B. Jr., Hatton D. D., Tassone F., Skinner M., Taylor A. K., (2001). Variability in FMRP and early development in males with fragile X syndrome American Journal of Mental Retardation106(1): 16–27

    Article  PubMed  Google Scholar 

  • Bailey D. B. Jr., Mesibov G. B., Hatton D. D., Clark R. D., Roberts J. E., Mayhew L., (1998b). Autistic behavior in young boys with fragile X syndrome Journal of Autism and Developmental Disorders28(6): 499–508

    Article  Google Scholar 

  • Bailey, D. B., Jr., Roberts, J. E., Hooper, S. R., Hatton, D. D., Mirrett, P. L., Roberts, J. E., & Schaff, J. M. (2004). Research on fragile X syndrome and autism: Implications for the study of genes, environments, and developmental language disorders. In M. Rice and S. Warren (Eds.), Developmental language disorders: From Phenotypes to etiologies. Mahwah, NJ: Lawrence Erlbaum

    Google Scholar 

  • Bailey D. B. Jr., Roberts J. E., Mirrett P., Hatton D. D., (2002). Identifying infants and toddlers with fragile X syndrome: Issues and recommendations Infants and Young Children 14(1): 24–33

    Article  Google Scholar 

  • Bailey D. B. Jr., Skinner D., Sparkman K. L., (2003). Discovering fragile X syndrome: Family experiences and perceptions Pediatrics 111(2): 407–416

    Article  PubMed  Google Scholar 

  • Baranek G. T., (1999). Autism during infancy: A retrospective video analysis of sensory-motor and social behaviors at 9–12 months of age Journal of Autism and Developmental Disorders29(3): 213–224

    Article  PubMed  CAS  Google Scholar 

  • Case-Smith J., (1995). Grasp, release, and bimanual skills in the first two years of life In Henderson A., Pehoski C., (Eds.), Hand function in the child Mosby St. Louis, MO (pp. 113–135)

    Google Scholar 

  • Cohen I. L., (1995). Behavioral profiles of autistic and nonautistic fragile X males Developmental Brain Dysfunction 8: 252–269

    Google Scholar 

  • Cohen I. L., Sudhalter V., Pfadt A., Jenkins E. C., Brown W. T., Vietze P. M., (1991). Why are autism and the fragile-X syndrome associated? Conceptual and methodological issues American Journal of Human Genetics48(2): 195–202

    PubMed  CAS  Google Scholar 

  • Crawford D. C., Meadows K. L., Newman J. L., Taft L. F., Pettay D. L., Gold L. B., et al. (1999). Prevalence and phenotype consequence of FRAXA and FRAXE alleles in a large, ethnically diverse, special education-needs population American Journal of Human Genetics64(2): 495–507

    Article  PubMed  CAS  Google Scholar 

  • Dawson G., Osterling J., (1997). Early intervention in autism In Guralnick M., (Ed.), The effectiveness of early intervention Brookes Baltimore, MD (pp. 307–326)

    Google Scholar 

  • Dunn W., (1997). The impact of sensory processing abilities on the daily lives of young children and their families: A conceptual model Infants and Young Children9: 23–35

    Article  Google Scholar 

  • Dykens E., Volkmar F. R., (1997). Medical conditions associated with autism In Cohen D. J., Volkmar F. R., (Eds.), Handbook of autism and pervasive developmental disorders Wiley New York (pp. 388–407)

    Google Scholar 

  • Feinstein C., Reiss A. L., (1998). Autism: The point of view from fragile X studies Journal of Autism and Developmental Disorders28(5): 393–405

    Article  PubMed  CAS  Google Scholar 

  • Gillberg C., Ehlers S., Schaumann H., Jakobsson G., Dahlgren S. O., Lindblom R., Bagenholm A., Tjuus T., Blidner E., (1990). Autism under age 3 years: A clinical study of 28 cases referred for autistic symptoms in infancy Journal of Child Psychology and Psychiatry31(6): 921–934

    Article  PubMed  CAS  Google Scholar 

  • Greenspan S.I., Wieder S., (1998). The Child with special needs: Encouraging intellectual and emotional growth Perseus Books Reading, MA

    Google Scholar 

  • Guralnick M. J., (1998). Effectiveness of early intervention for vulnerable children: A developmental perspective American Journal of Mental Retardation102(4): 319–345

    Article  PubMed  CAS  Google Scholar 

  • Hagerman R. J., (1997). Fragile X Syndrome: Meeting the challenges of diagnosis and care Contemporary Pediatrics14: 31–59

    Google Scholar 

  • Hessl D., Glaser B., Dyer-Friedman J., Blasey C., Hastie T., Gunnar M., et al. (2002). Cortisol and behavior in fragile X syndrome Psychoneuroendocrinology27(7): 855–872

    Article  PubMed  CAS  Google Scholar 

  • Newborg J., Stock J. R., Wnek L., Guidubaldi J., Svinicki J., (1984). The battelle developmetnal inventory DLM/Teaching Resources Allen, TX

    Google Scholar 

  • Osterling J., Dawson G., (1994). Early recognition of children with autism: A study of first birthday home videotapes Journal of Autism and Developmental Disorders24(3): 247–257

    Article  PubMed  CAS  Google Scholar 

  • Roberts J. E., Boccia M. L., Bailey D. B. Jr., Hatton D. D., Skinner M., (2001). Cardiovascular indices of physiological arousal in boys with fragile X syndrome Developmental Psychobiology39(2): 107–123

    Article  PubMed  CAS  Google Scholar 

  • Rogers S. J., Wehner D. E., Hagerman R., (2001). The behavioral phenotype in fragile X: Symptoms of autism in very young children with fragile X syndrome, idiopathic autism, and other developmental disorders Journal of Developmental and Behavioral Pediatrics22(6): 409–417

    PubMed  CAS  Google Scholar 

  • Schloper E., Reichler R. J., Renner B. R., (1988). The Childhood Autism Rating Scale Western Psychological Services Los Angeles, CA

    Google Scholar 

  • Soussignan R., Koch P., Montagner H., (1988). Behavioural and cardiovascular changes in children moving from kindergarten to primary school Journal of Child Psychology and Psychiatry29(3): 321–333

    Article  PubMed  CAS  Google Scholar 

  • Sparrow S., Balla D., Cicchetti D., (1984). Vineland Adaptive Behavior Scales American Guidance Service Circle Pines, MN

    Google Scholar 

  • Turner G., Webb T., Wake S., Robinson H., (1996). Prevalence of fragile X syndrome American Journal of Medical Genetics64(1): 196–197

    Article  PubMed  CAS  Google Scholar 

  • Walker E., Grimes K., Davis D., Smith A., (1993). Childhood precursors of schizophrenia: Facial expressions of emotion American Journal of Psychiatry142: 1654–1660

    Google Scholar 

  • Willemsen R., Anar B., De Diego Otero Y., de Vries B. B., Hilhorst-Hofstee Y., Smits A., et al. (1999). Noninvasive test for fragile X syndrome, using hair root analysis American Journal of Human Genetics65(1): 98–103

    Article  PubMed  CAS  Google Scholar 

  • Wing L., Gould J., (1979). Severe impairments of social interaction and associated abnormalities in children: Epidemiology and classification Journal of Autism and Developmental Disorders9: 11–29

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This research was funded in part by U.S. Department of Education, Office of Special Education Programs (Grant #H324C990042). Preliminary data were presented at the Gatlinburg Conference on Research and Theory in Intellectual and Developmental Disabilities, March 2003. The authors express their appreciation to the Carolina Fragile X Project, the participating families, and Fabian David, Michelle Rakes, Kelly Sullivan, Don Trull, and Anne Wheeler for assistance with aspects of video coding and editing.

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Correspondence to Grace T. Baranek.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s10803-006-0295-7

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Baranek, G.T., Danko, C.D., Skinner, M.L. et al. Video Analysis of Sensory-Motor Features in Infants with Fragile X Syndrome at 9–12 Months of Age. J Autism Dev Disord 35, 645–656 (2005). https://doi.org/10.1007/s10803-005-0008-7

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