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A role for mesencephalic dopamine in activation: commentary on Berridge (2006)

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References

  • Apicella P, Scarnati E, Schultz W (1991) Tonically discharging neurons of monkey striatum respond to preparatory and rewarding stimuli. Exp Brain Res 84:672–675

    Article  PubMed  CAS  Google Scholar 

  • Bardo MT, Bowling SL, Pierce RC (1990) Changes in locomotion and dopamine neurotransmission following amphetamine, haloperidol and exposure to novel environmental stimuli. Psychopharmacology 101:338–343

    Article  PubMed  CAS  Google Scholar 

  • Berridge KC (2006) The debate over dopamine’s role in reward: the case for incentive salience. Psychopharmacology DOI 10.1007/s00213-006-0578-x

  • Bilder RM, Volavka J, Lachman HM, Grace AA (2004) The catechol-o-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes. Neuropsychopharmacology 29:1943–1961

    Article  PubMed  CAS  Google Scholar 

  • Blackburn JR, Phillips AG (1987) Dopamine and preparatory behavior. I Effects of pimozide. Behav Neurosci 101:352–360

    Article  PubMed  CAS  Google Scholar 

  • Brown VJ, Robbins TW (1991) Simple and choice reaction time performance following unilateral striatal dopamine depletion in the rat: impaired motor readiness but preserved response preparation. Brain 114:513–525

    Article  PubMed  Google Scholar 

  • Crow TJ (1976) Specific monoamine systems as reward pathways. In: Wauquier A, Rolls ET (eds) Brain-stimulation reward. North-Holland, Amsterdam, pp 211–238

    Google Scholar 

  • Dalley JW, Laane K, Theobald DE, Armstrong HC, Corlett PR, Chudasama Y, Robbins TW (2005) Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens. Proc Acad Natl Sci USA 102:6189–6194

    Article  CAS  Google Scholar 

  • DiCiano P, Everitt BJ (2003) Differential control over drug-seeking behavior by drug-associated conditioned reinforcers and discriminative stimuli predictive of drug availability. Behav Neurosci 117:952–960

    Article  Google Scholar 

  • Everitt BJ (1990) Sexual motivation—a neural and behavioral analysis of the mechanisms underlying appetitive and copulatory responses of male rats. Neurosci Biobehav Rev 14:217–232

    Article  PubMed  CAS  Google Scholar 

  • Everitt BJ, Robbins TW (2005) Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8:1481–1489

    Article  PubMed  CAS  Google Scholar 

  • Everitt BJ, Parkinson JA, Olmstead MC, Arroyo M, Robledo P, Robbins TW (1999) Associative processes in addiction and reward: the role of amygdala–ventral striatal subsystems. Ann N Y Acad Sci 877:412–438

    Article  PubMed  CAS  Google Scholar 

  • Ferrario CR, Gorny G, Cromberg HS, Li YL, Kolb B, Robinson TE (2005) Neural and behavioral plasticity associated with the transition from controlled to escalated cocaine use. Biol Psychiatry 58:751–759

    Article  PubMed  CAS  Google Scholar 

  • Frank MJ, O’Reilly RC (2006) A mechanistic account of striatal dopamine function in human cognition: psychopharmacological studies with cabergoline and haloperidol. Behav Neurosci 120:497–517

    Article  PubMed  CAS  Google Scholar 

  • Goto Y, Grace AA (2005) Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior. Nat Neurosci 8:805–812

    Article  PubMed  CAS  Google Scholar 

  • Herberg LJ, Stephans DN, Franklin K (1976) Catecholamines and self-stimulation—evidence suggesting a reinforcing role for noradrenaline and a motivating role for dopamine. Pharmacol Biochem Behav 4:575–582

    Article  PubMed  CAS  Google Scholar 

  • Ito R, Dalley JW, Robbins TW, Everitt BJ (2002) Dopamine release in the dorsal striatum during cocaine-seeking behavior under control of a drug-associated cue. J Neurosci 22:6247–6253

    PubMed  CAS  Google Scholar 

  • Iversen SD, Koob GF (1977) Behavioral implications of dopaminergic neurones in the mesolimbic system. In: Costa E, Gessa GL (eds) Advances in biochemical psychopharmacology, vol. 16. Raven, New York, pp 209–214

    Google Scholar 

  • Koob GF, Riley S, Smith SC, Robbins TW (1978) Effects of 6-hydroxydopamine lesions to nucleus accumbens septi and olfactory tubercle on food intake, locomotor activity and amphetamine anorexia in the rat. J Comp Physiol Psychol 92:917–927

    Article  PubMed  CAS  Google Scholar 

  • Montague PR, Hyman SE, Cohen JD (2004) Computational roles for dopamine in behavioural control. Nature 431:760–767

    Article  PubMed  CAS  Google Scholar 

  • Nelson A, Killcross S (2006) Amphetamine exposure enhances habit formation. J Neurosci 26:3805–3812

    Article  PubMed  CAS  Google Scholar 

  • Niv Y, Daw ND, Joel D, Dayan P (2006) Tonic dopamine: opportunity costs and the control of response vigor. Psychopharmacology DOI 10.1007/s00213-006-0502-4

  • Robbins TW, Everitt BJ (1982) Functional studies of the central catecholamines. Int Rev Neurobiol 23:303–365

    Article  PubMed  CAS  Google Scholar 

  • Robbins TW, Everitt BJ (1987) Psychopharmacological studies of arousal and attention. In: Stahl S, Iversen SD, Goodman E (eds) Cognitive neurochemistry. Oxford University Press OUP, Oxford, pp 135–170

    Google Scholar 

  • Robbins TW, Everitt BJ (1992) Functions of dopamine in the dorsal and ventral striatum. Semin Neurosci 4:119–127

    Article  Google Scholar 

  • Robbins TW, Everitt BJ (1995) Arousal systems and attention. In: Gazzaniga M et al (eds) The cognitive neurosciences. MIT, Cambridge, MA, pp 703–720

    Google Scholar 

  • Robbins TW, Taylor JR, Cador M, Everitt BJ (1989) Limbic–striatal interactions and reward-related processes. Neurosci Biobehav Rev 13:155–162

    Article  PubMed  CAS  Google Scholar 

  • Robinson TE, Berridge KC (2003) Addiction. Annu Rev Psychol 54:25–53

    Article  PubMed  Google Scholar 

  • Salamone JD, Correa M, Mingote SM, Weber SM (2005) Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine. Curr Opin Pharmacol 5:34–41

    Article  PubMed  CAS  Google Scholar 

  • Schultz W (2002) Getting formal with dopamine and reward. Neuron 36:241–253

    Article  PubMed  CAS  Google Scholar 

  • Spryaki C, Fibiger HC, Phillips AG (1982) The attenuation by haloperidol of place preference conditioning using food reinforcement. Psychopharmacology 77:379–382

    Article  Google Scholar 

  • Taylor JR, Robbins TW (1984) Enhanced behavioral control by conditioned reinforcers produced by intracerebral injections of d-amphetamine in the rat. Psychopharmacology 84:405–412

    Article  PubMed  CAS  Google Scholar 

  • Taylor JR, Robbins TW (1986) 6-Hydroxydopamine lesions of the nucleus accumbens, but not of the caudate nucleus, attenuate enhanced responding with reward-related stimuli produced by intra-accumbens d-amphetamine. Psychopharmacology 90:390–397

    Article  PubMed  CAS  Google Scholar 

  • Volkow N, Wang G-J, Telang F, Fowler JS, Logan J, Childress A-R, Jayne M, Ma Y, Wong C (2006) Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction. J Neurosci 26:6583–6588

    Article  PubMed  CAS  Google Scholar 

  • Walton ME, Bannerman DM, Rushworth MFS (2002) The role of medial frontal cortex in effort-based decision-making. J Neurosci 22:10996–11003

    PubMed  CAS  Google Scholar 

  • Wise R (2004) Dopamine, learning and motivation. Nat Rev Neurosci 5:483–494

    Article  PubMed  CAS  Google Scholar 

  • Wyvell C, Berridge KC (2001) Incentive-sensitization by previous amphetamine exposure: increased cue-triggered ‘wanting’ for sucrose reward. J Neurosci 21:7831–7840

    PubMed  CAS  Google Scholar 

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Acknowledgements

Thanks are due to all of our colleagues who have contributed to these ideas, Kent Berridge, and an anonymous referee who both commented on a first draft. The University of Cambridge Behavioral and Clinical Neurosciences Institute is supported by a joint grant from the MRC and the Wellcome Trust. The work is also supported by an MRC Programme Grant to BJE, TWR, and A. Dickinson.

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  1. University of Cambridge, Cambridge, UK

    T. W. Robbins & B. J. Everitt

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  1. T. W. Robbins
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  2. B. J. Everitt
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Correspondence to T. W. Robbins.

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Robbins, T.W., Everitt, B.J. A role for mesencephalic dopamine in activation: commentary on Berridge (2006). Psychopharmacology 191, 433–437 (2007). https://doi.org/10.1007/s00213-006-0528-7

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