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Functional characteristics of lumbar visceral afferent fibres from the urinary bladder and the urethra in the cat

  • Excitable Tissues and Central Nervous Physiology
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Abstract

Neural activity of lumbar visceral afferents supplying the urinary bladder and urethra was analyzed systematically in the cat. The afferent fibres were isolated either from the white rami L3 and L4 in a preparation with closed peritoneal cavity, or from the lumbar splanchnic nerves in a preparation with open peritoneal cavity and investigated for various functional parameters. Seventy five single units and 9 multiunit bundles were analyzed. 1) About 50% of the afferent units had some ongoing activity (0.2 to 1 imp/s). Two thirds of the afferent axons were thin myelinated (conduction velocity 3–15 m/s), the rest were presumably unmyelinated (conduction velocity below 2 m/s). 2) The receptive fields of the afferent units consisted —with one exception — of single mechanosensitive sites on the surface of the bladder and urethra. Most receptive fields were situated on the dorsal side of the bladder. 3) Afferents with receptive fields on or in the bladder wall responded in a graded manner to passive distension and isovolumetric contraction at intravesical pressures ranging from about 10 to 70 mm Hg. The thresholds for exciting the afferent units ranged from less than 10 mm Hg to about 30 mm Hg intravesical pressure, most of them being less than 20 mm Hg. Generally, the discharge rate of the afferent units gave a reliable representation of the intravesical pressure to the lumbar spinal cord. 4) Urethral units exhibited either no responses to the graded distensions and contractions of the urinary bladder, or responded with low discharge rates at higher intravesical pressures. 5) The results do not support the notion that noxious events in the urinary bladder are encoded by “specific” nociceptive visceral afferents to the lumbar spinal cord but possibly by some other mechanism of encoding.

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References

  1. Bahns E, Ernsberger U, Jänig W, Nelke A (1984) Reactions of visceral afferents in the hypogastric nerve to distension and contraction of the urinary bladder. Pflügers Arch 402:38

    Google Scholar 

  2. Bahns E, Ernsberger U, Jänig W, Nelke A (1986) Discharge properties of mechanosensitive afferents supplying the retroperitoneal space. Pflügers Arch 407:519–525

    Google Scholar 

  3. Bahns E, Halsband U, Jänig W (1985) Reaction of visceral afferents in the pelvic nerve to distension and contraction of the urinary bladder in the cat. Neurosci Lett Suppl 22:S86

    Google Scholar 

  4. Baron R, Jänig W, McLachlan EM (1985) The afferent and sympathetic components of the lumbar spinal outflow to the colon and pelvic organs in the cat: I. The hypogastric nerve. J Comp Neurol 238:135–146

    Google Scholar 

  5. Baron R, Jänig W, McLachlan EM (1985) The afferent and sympathetic components of the lumbar spinal outflow to the colon and pelvic organs in the cat: II. The lumbar splanchnic nerves. J Comp Neurol 238:147–157

    Google Scholar 

  6. Baron R, Jänig W, McLachlan EM (1985) The afferent and sympathetic components of the lumbar spinal outflow to the colon and pelvic organs in the cat: III. The colonic nerves, incorporating an analysis of all components of the lumbar prevertebral outflow. J Comp Neurol 238:158–168

    Google Scholar 

  7. Blumberg H, Haupt P, Jänig W, Kohler W (1983) Encoding of visceral noxious stimuli in the discharge patterns of visceral afferent fibres from the colon. Pflügers Arch 398:33–40

    Google Scholar 

  8. Bors E, Ma KT, Parker RB (1956) Observations on some modalities of bladder sensation. J Urol 76:566–575

    Google Scholar 

  9. Cervero F (1982) Afferent activity evoked by natural stimulation of the biliary system in the ferret. Pain 13:137–151

    Google Scholar 

  10. Denny-Brown D, Robertson EG (1933) On the physiology of micturition. Brain 56:149–190

    Google Scholar 

  11. Floyd K, Hick VE, Morrison JFB (1976) Mechanosensitive afferent units in the hypogastric nerve of the cat. J Physiol 259:457–471

    Google Scholar 

  12. Goldscheider A (1920) Das Schmerzproblem. Springer, Berlin

    Google Scholar 

  13. Gunterberg B, Norlén L, Stener B, Sundin T (1975) Neurologic evaluation after resection of the sacrum. Invest Neurol 13:183–188

    Google Scholar 

  14. Haupt P, Jänig W, Kohler W (1983) Response pattern of visceral afferent fibres, supplying colon, upon chemical and mechanical stimuli. Pflügers Arch 398:41–47

    Google Scholar 

  15. Head H, Riddoch G (1917) The automatic bladder, excessive sweating and some other reflex conditions, in gross injuries of the spinal cord. Brain 40:188–263

    Google Scholar 

  16. Iggo A (1955) Tension receptors in the stomach and the urinary bladder. J Physiol 128:593–607

    Google Scholar 

  17. Iggo A (1966) Physiology of visceral afferent systems. Acta Neurovegetativa 28:121–134

    Google Scholar 

  18. Jänig W, Morrison JFB (1986) Functional properties of spinal visceral afferents supplying abdominal and pelvic organs with special emphasis on visceral nociception. In: Cervero F, Morrison JFB (eds) Visceral sensation. Progress in Brain Res 67:87–114

  19. Kuo DC Hisamitsu T, de Groat WC (1984) A sympathetic projection from sacral paravertebral ganglia to the pelvic nerve and to postganglionic nerves on the surface of the urinary bladder and large intestine of the cat. J Comp Neurol 226:76–86

    Google Scholar 

  20. Langley JN, Anderson HK (1895) The innervation of the pelvic and adjoining viscera. Part II. The bladder. J Physiol 19:71–84

    Google Scholar 

  21. Learmonth JR, Glas CM (1931) A contribution to the neurophysiology of the urinary bladder in man. Brain 54:147–176

    Google Scholar 

  22. Malliani A, Lombardi F (1982) Consideration of the fundamental mechanisms eliciting cardiac pain. Am Heart J 103:575–578

    Google Scholar 

  23. Malliani A, Pagani M, Lombardi F (1984) Visceral versus somatic mechanisms. In: Wall PD, Melzack R (eds) Textbook of pain. Churchill-Livingstone, Edinburgh, pp 100–108

    Google Scholar 

  24. McDonald DF, Murphy GP (1959) Quantitative studies of perception of thermal stimuli in the normal and neurogenic urinary bladder. J Appl Physiol 14:204–206

    Google Scholar 

  25. Moore TD (1924) Bladder sensibility. Arch Surg 9:176–187

    Google Scholar 

  26. Morgan C, de Groat WC, Nadelhaft I (1986) The spinal distribution of sympathetic preganglionic and visceral primary afferent neurons that send axons into the hypogastric nerves of the cat. J Comp Neurol 243:23–40

    Google Scholar 

  27. Morrison JFB (1981) Sensory processing in spinal afferent pathways from the bladder. In: Grastyán E, Molnár P (eds) Sensory functions, Adv Physiol Sci, vol 16. Akadémiai Kiado, Budapest: Pergamon Press, Oxford, pp 325–333

    Google Scholar 

  28. Mukherjee SR (1957) Effect of bladder distension on arterial blood pressure and renal circulation in acute spinal cats. J Physiol 138:300–306

    Google Scholar 

  29. Müller LR (1908) Über die Empfindungen in unseren inneren Organen. Mitteilungen aus den Grenzgebieten der Medizin und Chirurgie, vol 18:600–641

    Google Scholar 

  30. Murphy JJ, Schoenberg HW (1960) Observations on intravesical pressure changes during micturition. J Urol 84:106–110

    Google Scholar 

  31. Nathan PW (1952) Micturition reflexes in man. J Neurol Neurosurg Psychiatr 15:148–149

    Google Scholar 

  32. Nathan PW (1956) Sensations associated with micturition. Br J Urol 28:126–131

    Google Scholar 

  33. Perl ER (1984) Pain and nociception. In: Handbook of physiology, section 1: The nervous system. vol III: Sensory processes Darian-Smith I (ed). American Physiological Society, Bethesda Maryland, pp 915–975

    Google Scholar 

  34. Ray BS, Neill CL (1947) Abdominal visceral sensation in man. Ann Surg 126:709–726

    Google Scholar 

  35. Riddoch G (1921) Conduction of sensory impulses from the bladder by the inferior hypogastrics and the central afferent connections of these nerves. J Physiol 54:CXXXIV

    Google Scholar 

  36. Scott FB, Queseda EM, Cardus D (1984) Studies on the dynamics of micturition: observations on healthy men. J Urol 92:455–463

    Google Scholar 

  37. Watkins AL (1938) Reflex responses of the nictitating membrane and the blood pressure to distension of the bladder and rectum. Am J Physiol 121:32–39

    Google Scholar 

  38. Winter DL (1971) Receptor characteristics and conduction velocities in bladder afferents. J Psychiatr Res 8:225–235

    Google Scholar 

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Bahns, E., Ernsberger, U., Jänig, W. et al. Functional characteristics of lumbar visceral afferent fibres from the urinary bladder and the urethra in the cat. Pflugers Arch. 407, 510–518 (1986). https://doi.org/10.1007/BF00657509

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  • DOI: https://doi.org/10.1007/BF00657509

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