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Metabotropic Actions of Kainate Receptors in the Regulation of IsAHP and Excitability in CA1 Pyramidal Cells

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Book cover Kainate Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 717))

Abstract

Kainate receptors (KARs) mediate postsynaptic responses in CA3 pyramidal cells and CA1 interneurones in the hippocampus. In CA1 pyramidal cells knockout studies have inidcated the presence of functional GluR6-containing KARs, however in this region they made no ionotropic contribution to the synaptic responses. In the meantime, a metabotropic function was reported for presynaptic KARs modulating transmitter release in CA1. We examined the possibility that KARs in CA1 pyramidal cells have a metabotropic function. Kainate is known to inhibit a slow afterhyperpolarization current that regulates excitability in hippocampus and can be modulated by a number of G protein coupled receptors. We showed that KARs activation reduces slow afterhyperpolarization current in CA1 pyramidal cells via metabotropic action and elucidated the transduction mechanism(s) underlying this action.

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Author information

Authors and Affiliations

  1. Circadian and Visual Neuroscience Group, Nuffield Laboratory of Ophthalmology, University of Oxford, Levels 5 and 6 West Wing, The John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK

    Zara Melyan

Authors
  1. Zara Melyan
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  2. Howard V. Wheal
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Corresponding author

Correspondence to Zara Melyan .

Editor information

Editors and Affiliations

  1. Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, Spain

    Antonio Rodríguez-Moreno PhD

  2. Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK

    Talvinder S. Sihra PhD

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© 2011 Landes Bioscience and Springer Science+Business Media, LLC

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Melyan, Z., Wheal, H.V. (2011). Metabotropic Actions of Kainate Receptors in the Regulation of IsAHP and Excitability in CA1 Pyramidal Cells. In: Rodríguez-Moreno, A., Sihra, T.S. (eds) Kainate Receptors. Advances in Experimental Medicine and Biology, vol 717. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9557-5_5

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