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Behavioral Neuroscience of Motivation pp 231–257Cite as

Mesolimbic Dopamine and the Regulation of Motivated Behavior

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Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 27))

Abstract

It has been known for some time that nucleus accumbens dopamine (DA) is involved in aspects of motivation , but theoretical approaches to understanding the functions of DA have continued to evolve based upon emerging data and novel concepts. Although it has become traditional to label DA neurons as “reward” neurons, the actual findings are more complicated than that, because they indicate that DA neurons can respond to a variety of motivationally significant stimuli. Moreover, it is important to distinguish between aspects of motivation that are differentially affected by dopaminergic manipulations. Studies that involve nucleus accumbens DA antagonism or depletion indicate that accumbens DA does not mediate primary food motivation or appetite. Nevertheless, DA is involved in appetitive and aversive motivational processes including behavioral activation , exertion of effort, sustained task engagement, and Pavlovian-to-instrumental transfer. Interference with accumbens DA transmission affects instrumental behavior in a manner that interacts with the response requirements of the task and also shifts effort-related choice behavior, biasing animals toward low-effort alternatives. Dysfunctions of mesolimbic DA may contribute to motivational symptoms seen in various psychopathologies, including depression , schizophrenia, parkinsonism, and other disorders.

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Acknowledgements

This work was supported by a grant to J.S. from the National Institute of Mental Health (MH094966), and to Mercè Correa from U.J.I. P1.1A2013-01.

Disclosure/Conflict of Interest

J. Salamone has received grants from Merck-Serrono, Pfizer, Roche, Shire, and Prexa.

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Authors and Affiliations

  1. Department of Psychology, University of Connecticut, Storrs, CT, 06269-1020, USA

    John D. Salamone, Samantha E. Yohn & Mercè Correa

  2. Àrea de Psicobiologia, Universitat Jaume I, 12071, Castelló, Spain

    Marta Pardo, Laura López-Cruz, Noemí SanMiguel & Mercè Correa

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  1. John D. Salamone
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Correspondence to John D. Salamone .

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  1. New York State Psychiatric Institute, Columbia University Medical Center, New York, New York, USA

    Eleanor H. Simpson

  2. Barnard College, Columbia University Barnard College, New York, New York, USA

    Peter D. Balsam

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Salamone, J.D., Pardo, M., Yohn, S.E., López-Cruz, L., SanMiguel, N., Correa, M. (2015). Mesolimbic Dopamine and the Regulation of Motivated Behavior. In: Simpson, E., Balsam, P. (eds) Behavioral Neuroscience of Motivation. Current Topics in Behavioral Neurosciences, vol 27. Springer, Cham. https://doi.org/10.1007/7854_2015_383

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