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Sensitization Processes in Drug Addiction

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Behavioral Neuroscience of Drug Addiction

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 3))

Abstract

In 1993, Robinson and Berridge published their first review that laid out the incentive sensitization theory of addiction (Robinson and Berridge 1993 Brain Res Rev 18:247). Its basic point is that repeated exposure to drugs of abuse causes hypersensitivity to drugs and drug-associated stimuli of the neural circuits mediating incentive salience, an important way in which motivational stimuli influence behavior. In laymen’s terms, it states that this drug-induced hypersensitivity of motivational circuitry would mediate an increase in drug “wanting,” thus being responsible for the dramatically exaggerated motivation for drugs displayed by addicts. This theory has been exceptionally influential, as evidenced by the fact that the original review paper about this theory (Robinson and Berridge 1993 Brain Res Rev 18:247) has been cited 2,277 times so far, and subsequent updates of this view (Robinson and Berridge 2000 Addiction 95(Suppl 2):S91; Robinson and Berridge 2001 Addiction 96:103; Robinson and Berridge 2003 Ann Rev Psychol 54:25) have been cited 274, 297, and 365 times, respectively, adding up to more than 3,200 citations within 15 years. The present chapter aims to delineate the merits and limitations of the incentive sensitization view of addiction, and whether incentive sensitization occurs in humans. We conclude that since incentive sensitization most prominently occurs after the first few drug exposures, it may represent an important initial step in the addiction process. During the expression of full-blown addiction, characterized by loss of control over drug intake and use of large quantities of drugs, the expression of incentive sensitization may be transiently suppressed. However, detoxification and the gradual disappearance of tolerance and withdrawal symptoms may unmask sensitization, which could then play an important role in the high risk of relapse.

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References

  • Ahmed SH (2005) Imbalance between drug and non-drug reward availability: A major risk factor for addiction. Eur J Pharmacol 526:9–20

    Article  CAS  PubMed  Google Scholar 

  • Ahmed SH, Cador M (2006) Dissociation of psychomotor sensitization from compulsive cocaine consumption. Neuropsychopharmacology 31:563–571

    Article  CAS  PubMed  Google Scholar 

  • Ahmed SH, Koob GF (1998) Transition from moderate to excessive drug intake: change in hedonic set point. Science 282:298–300

    Article  CAS  PubMed  Google Scholar 

  • Ahmed SH, Lin D, Koob GF, Parsons LH (2003) Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. J Neurochem 86:102–113

    Article  CAS  PubMed  Google Scholar 

  • American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, IV-TR edn. American Psychiatric Association, Washington, DC

    Google Scholar 

  • Babbini M, Davis WM (1972) Time-dose relationships for locomotor activity effects of morphine after acute or repeated treatment. Br J Pharmacol 46:213–224

    CAS  PubMed  Google Scholar 

  • Bachtell RK, Choi K-H, Simmons DL, Falcon E, Monteggia LM, Neve RL, Self DW (2008) Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behavior. Eur J Neurosci 27:2229–2240

    Article  PubMed  Google Scholar 

  • Bartlett E, Hallin A, Chapman B, Angrist B (1997) Selective sensitization to the psychosis-inducing effects of cocaine: a possible marker for addiction relapse vulnerability? Neuropsychopharmacology 16:77–82

    Article  CAS  PubMed  Google Scholar 

  • Bell K, Kalivas PW (1996) Context-specific cross-sensitization between systemic cocaine and intra-accumbens AMPA infusion in the rat. Psychopharmacology 127:377–383

    CAS  PubMed  Google Scholar 

  • Ben-Shahar O, Ahmed SH, Koob GF, Ettenberg A (2004) The transition from controlled to compulsive drug use is associated with a loss of sensitization. Brain Res 995:46–54

    Article  CAS  PubMed  Google Scholar 

  • Ben-Shahar O, Moscarello JM, Jacob B, Roarty MP, Ettenberg A (2005) Prolonged daily exposure to IV cocaine results in tolerance to its stimulant effects. Pharmacol Biochem Behav 82:411–416

    Article  CAS  PubMed  Google Scholar 

  • Berridge KC (2007) The debate over dopamine’s role in reward: the case for incentive salience. Psychopharmacology 191:391–431

    Article  CAS  PubMed  Google Scholar 

  • Berridge KC, Robinson TE (1998) What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Rev 28:309–369

    Article  CAS  PubMed  Google Scholar 

  • Boileau I, Dagher A, Leyton M, Gunn R, Baker GB, Diksic M, Benkelfat C (2006) Modeling sensitization to stimulants in humans. Arch Gen Psychiatry 63:1386–1395

    Article  CAS  PubMed  Google Scholar 

  • Bradberry CW (2007) Cocaine sensitization and dopamine mediation of cue effects in rodents, monkeys, and humans: areas of agreement, disagreement, and implications for addiction. Psychopharmacology 191:705–717

    Article  CAS  PubMed  Google Scholar 

  • Cardinal RN, Parkinson JA, Hall J, Everitt BJ (2002) Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev 26:321–352

    Article  PubMed  Google Scholar 

  • Clarke PBS, Kumar R (1983) The effects of nicotine on locomotor activity in non-tolerant and tolerant rats. Br J Pharmacol 78:329–337

    CAS  PubMed  Google Scholar 

  • Conrad KL, Tseng KY, Uejima JL, Reimers JM, Heng L-J, Shaham Y, Marinelli M, Wolf ME (2008) Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature 454:118–121

    Article  CAS  PubMed  Google Scholar 

  • Cornish JL, Duffy P, Kalivas PW (1999) A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior. Neuroscience 93:1359–1367

    Article  CAS  PubMed  Google Scholar 

  • Covington HE III, Miczek KA (2001) Repeated social-defeat stress, cocaine or morphine – Effects on behavioral sensitization and intravenous cocaine self-administration “binges”. Psychopharmacology 158:388–398

    Article  CAS  PubMed  Google Scholar 

  • De Vries TJ, Schoffelmeer ANM, Binnekade R, Mulder AH, Vanderschuren LJMJ (1998) Drug-induced reinstatement of heroin- and cocaine-seeking behaviour following long-term extinction is associated with expression of behavioural sensitization. Eur J Neurosci 10:3565–3571

    Article  PubMed  Google Scholar 

  • De Vries TJ, Schoffelmeer ANM, Binnekade R, Vanderschuren LJMJ (1999) Dopaminergic mechanisms mediating the incentive to seek cocaine and heroin following long-term withdrawal of IV drug self-administration. Psychopharmacology 143:254–260

    Article  PubMed  Google Scholar 

  • De Vries TJ, Schoffelmeer ANM, Binnekade R, Raasø H, Vanderschuren LJMJ (2002) Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization. Neuropsychopharmacology 26:18–26

    Article  PubMed  Google Scholar 

  • Deroche V, Le Moal M, Piazza PV (1999) Cocaine self-administration increases the incentive motivational properties of the drug in rats. Eur J Neurosci 11:2731–2736

    Article  CAS  PubMed  Google Scholar 

  • Deroche-Gamonet V, Belin D, Piazza PV (2004) Evidence for addiction-like behavior in the rat. Science 305:1014–1017

    Article  CAS  PubMed  Google Scholar 

  • Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85:5274–5278

    Article  PubMed  Google Scholar 

  • Dias C, Lachize S, Boilet V, Huitelec E, Cador M (2004) Differential effects of dopaminergic agents on locomotor sensitisation and on the reinstatement of cocaine-seeking and food-seeking behaviour. Psychopharmacology 175:414–427

    CAS  PubMed  Google Scholar 

  • Everitt BJ, Robbins TW (2005) Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8:1481–1489

    Article  CAS  PubMed  Google Scholar 

  • Famous KR, Kumaresan V, Sadri-Vakili G, Schmidt HD, Mierke DF, Cha J-HJ, Pierce RC (2008) Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking. J Neurosci 28:11061–11070

    Article  CAS  PubMed  Google Scholar 

  • Ferrario CR, Robinson TE (2007) Amphetamine pretreatment accelerates the subsequent escalation of cocaine self-administration behavior. Eur Neuropsychopharmacol 17:352–357

    Article  CAS  PubMed  Google Scholar 

  • Ferrario CR, Gorny G, Crombag HS, Li Y, Kolb B, Robinson TE (2005) Neural and behavioral plasticity associated with the transition from controlled to escalated cocaine use. Biol Psychiatry 58:751–759

    Article  CAS  PubMed  Google Scholar 

  • Fiorino DF, Phillips AG (1999a) Facilitation of sexual behavior and enhanced dopamine efflux in the nucleus accumbens of male rats after d-amphetamine-induced behavioral sensitization. J Neurosci 19:456–463

    CAS  PubMed  Google Scholar 

  • Fiorino DF, Phillips AG (1999b) Facilitation of sexual behavior in male rats following d-amphetamine-induced behavioral sensitization. Psychopharmacology 142:200–208

    Article  CAS  PubMed  Google Scholar 

  • Gaiardi M, Bartoletti M, Bacchi A, Gubellini C, Costa M, Babbini M (1991) Role of repeated exposure to morphine in determining its affective properties: place and taste conditioning studies in rats. Psychopharmacology 103:183–186

    Article  CAS  PubMed  Google Scholar 

  • Harmer CJ, Phillips GD (1998) Enhanced appetitive conditioning following repeated pretreatment with d-amphetamine. Behav Pharmacol 9:299–308

    Article  CAS  PubMed  Google Scholar 

  • Harmer CJ, Phillips GD (1999) Enhanced conditioned inhibition following repeated pretreatment with d-amphetamine. Psychopharmacology 142:120–131

    Article  CAS  PubMed  Google Scholar 

  • Harris GC, Aston-Jones G (2003a) Altered motivation and learning following opiate withdrawal: evidence for prolonged dysregulation of reward processing. Neuropsychopharmacology 28:865–871

    Article  CAS  PubMed  Google Scholar 

  • Harris GC, Aston-Jones G (2003b) Enhanced morphine preference following prolonged abstinence: Association with increased Fos expression in the extended amygdala. Neuropsychopharmacology 28:292–299

    Article  CAS  PubMed  Google Scholar 

  • Horger BA, Shelton K, Schenk S (1990) Preexposure sensitizes rats to the rewarding effects of cocaine. Pharmacol Biochem Behav 37:707–711

    Article  CAS  PubMed  Google Scholar 

  • Horger BA, Giles MK, Schenk S (1992) Preexposure to amphetamine and nicotine predisposes rats to self-administer a low dose of cocaine. Psychopharmacology 107:271–276

    Article  CAS  PubMed  Google Scholar 

  • Johanson CE, Uhlenhuth EH (1981) Drug preference and mood in humans: repeated assessment of d-amphetamine. Pharmacol Biochem Behav 14:159–163

    Article  CAS  PubMed  Google Scholar 

  • Joyce EM, Iversen SD (1984) Dissociable effects of 6-OHDA-induced lesions of neostriatum on anorexia, locomotor activity and stereotypy: the role of behavioural competition. Psychopharmacology 83:363–366

    Article  CAS  PubMed  Google Scholar 

  • Kalivas PW, Alesdatter JE (1993) Involvement of N-methyl-d-aspartate receptor stimulation in the ventral tegmental area and amygdala in behavioral sensitization to cocaine. J Pharmacol Exp Ther 267:486–495

    CAS  PubMed  Google Scholar 

  • Kalivas PW, Stewart J (1991) Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity. Brain Res Rev 16:223–244

    Article  CAS  PubMed  Google Scholar 

  • Kegeles LS, Zea-Ponce Y, Abi-Dargham A, Rodenhiser J, Wang T, Weiss R, Van Heertum RL, Mann JJ, Laruelle M (1999) Stability of [123I]IBZM SPECT measurement of amphetamine-induced striatal dopamine release in humans. Synapse 31:302–308

    Article  CAS  PubMed  Google Scholar 

  • Kelly PH, Seviour PW, Iversen SD (1975) Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Res 94:507–522

    Article  CAS  PubMed  Google Scholar 

  • Kelly TH, Foltin RW, Fischman MW (1991) The effects of repeated amphetamine exposure on multiple measures of human behavior. Pharmacol Biochem Behav 38:417–426

    Article  CAS  PubMed  Google Scholar 

  • Knackstedt LA, Kalivas PW (2007) Extended access tot cocaine self-administration enhances drug-primed reinstatement but not behavioral sensitization. J Pharmacol Exp Ther 322:1103–1109

    Article  CAS  PubMed  Google Scholar 

  • Kollins SH, Rush CR (2002) Sensitization to the cardiovascular but not subject-rated effects of oral cocaine in humans. Biol Psychiatry 51:143–150

    Article  CAS  PubMed  Google Scholar 

  • Koob GF (1992) Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Neurosci 13:1771–1784

    Google Scholar 

  • Koob GF, Ahmed SH, Boutrel B, Chen SA, Kenny PJ, Markou A, O’Dell LE, Parsons LH, Sanna PP (2004) Neurobiological mechanisms in the transition from drug use to drug dependence. Neurosci Biobehav Rev 27:739–749

    Article  CAS  PubMed  Google Scholar 

  • Lack CM, Jones SR, Roberts DCS (2008) Increased breakpoints on a progressive ratio schedule reinforced by IV cocaine are associated with reduced locomotor activation and reduced dopamine efflux in nucleus accumbens shell in rats. Psychopharmacology 195:517–525

    Article  CAS  PubMed  Google Scholar 

  • Lenoir M, Ahmed SH (2007) Heroin-induced reinstatement is specific to compulsive heroin use and dissociable from heroin reward and sensitization. Neuropsychopharmacology 32:616–624

    Article  CAS  PubMed  Google Scholar 

  • Lenoir M, Ahmed SH (2008) Supply of a nondrug substitute reduces escalated heroin consumption. Neuropsychopharmacology 33:2272–2282

    Article  PubMed  Google Scholar 

  • Lenoir M, Serre F, Cantin L, Ahmed SH (2007) Intense sweetness surpasses cocaine reward. PLoS ONE 2:e698

    Article  PubMed  CAS  Google Scholar 

  • Lett BT (1989) Repeated exposures intensify rather than diminish the rewarding effects of amphetamine, morphine, and cocaine. Psychopharmacology 98:357–362

    Article  CAS  PubMed  Google Scholar 

  • Liu Y, Roberts DCS, Morgan D (2005a) Effects of extended-access self-administration and deprivation on breakpoints maintained by cocaine in rats. Psychopharmacology 179:644–651

    Article  CAS  PubMed  Google Scholar 

  • Liu Y, Roberts DCS, Morgan D (2005b) Sensitization of the reinforcing effects of self-administered cocaine in rats: effects of dose and intravenous injection speed. Eur J Neurosci 22:195–200

    Article  PubMed  Google Scholar 

  • Liu Y, Morgan D, Roberts DCS (2007) Cross-sensitization of the reinforcing effects of cocaine and amphetamine in rats. Psychopharmacology 195:369–375

    Article  CAS  PubMed  Google Scholar 

  • Lorrain DS, Arnold GM, Vezina P (2000) Previous exposure to amphetamine increases incentive to obtain the drug: long-lasting effects revealed by the progressive ratio schedule. Behav Brain Res 107:9–19

    Article  CAS  PubMed  Google Scholar 

  • Magos L (1969) Persistence of the effect of amphetamine on stereotyped activity in rats. Eur J Pharmacol 6:200–201

    Article  CAS  PubMed  Google Scholar 

  • Mantsch JR, Yuferov V, Mathieu-Kia AM, Ho A, Kreek MJ (2004) Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. Psychopharmacology 175:26–36

    Article  CAS  PubMed  Google Scholar 

  • Manzanedo C, Aguilar MA, Rodriguez-Arias M, Minarro J (2005) Sensitization to the rewarding effects of morphine depends on dopamine. NeuroReport 16:201–205

    Article  CAS  PubMed  Google Scholar 

  • Martinez D, Gil R, Slifstein M, Hwang DR, Huang Y, Perez A, Kegeles L, Talbot P, Evans S, Krystal J, Laruelle M, Abi-Dargham A (2005) Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum. Biol Psychiatry 58:779–786

    Article  CAS  PubMed  Google Scholar 

  • Martinez D, Narendran R, Foltin RW, Slifstein M, Hwang D-R, Broft A, Huang Y, Cooper TB, Fischman MW, Kleber HD, Laruelle M (2007) Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine. Am J Psychiatry 164:622–629

    Article  PubMed  Google Scholar 

  • Mateo Y, Lack CM, Morgan D, Roberts DCS, Jones SR (2005) Reduced dopamine terminal function and insensitivity to cocaine following cocaine binge self-administration and deprivation. Neuropsychopharmacology 30:1455–1463

    Article  CAS  PubMed  Google Scholar 

  • Mead AN, Crombag HS, Rocha BA (2004) Sensitization of psychomotor stimulation and conditioned reward in mice: differential modulation by contextual learning. Neuropsychopharmacology 29:249–258

    Article  PubMed  Google Scholar 

  • Mendrek A, Blaha CD, Phillips AG (1998) Pre-exposure of rats to amphetamine sensitizes self-administration of this drug under a progressive ratio schedule. Psychopharmacology 135:416–422

    Article  CAS  PubMed  Google Scholar 

  • Meririnne E, Kankaanpää A, Seppälä T (2001) Rewarding properties of methylphenidate: sensitization by prior exposure to the drug and effects of dopamine D1-and D2-receptor antagonists. J Pharmacol Exp Ther 298:539–550

    CAS  PubMed  Google Scholar 

  • Morgan D, Smith MA, Roberts DCS (2005) Binge self-administration and deprivation produces sensitization to the reinforcing effects of cocaine in rats. Psychopharmacology 178:309–316

    Article  CAS  PubMed  Google Scholar 

  • Morgan D, Liu Y, Roberts DCS (2006) Rapid and persistent sensitization to the reinforcing effects of cocaine. Neuropsychopharmacology 31:121–128

    Article  CAS  PubMed  Google Scholar 

  • Narita M, Akai H, Nagumo Y, Sunagawa N, Hasebe K, Nagase H, Kita T, Hara C, Suzuki T (2004) Implications of protein kinase C in the nucleus accumbens in the development of sensitization to methamphetamine in rats. Neuroscience 127:941–948

    Article  CAS  PubMed  Google Scholar 

  • Nocjar C, Panksepp J (2002) Chronic intermittent amphetamine pretreatment enhances future appetitive behavior for drug- and natural-reward: interaction with environmental variables. Behav Brain Res 128:189–203

    Article  CAS  PubMed  Google Scholar 

  • Nocjar C, Panksepp J (2007) Prior morphine experience induced long-term increases in social interest and in appetitive behavior for natural reward. Behav Brain Res 181:191–199

    Article  CAS  PubMed  Google Scholar 

  • Nordquist RE, Voorn P, De Mooij-van Malsen JG, Joosten RNJMA, Pennartz CMA, Vanderschuren LJMJ (2007) Augmented reinforcer value and accelerated habit formation after repeated amphetamine treatment. Eur Neuropsychopharmacol 17:532–540

    Article  CAS  PubMed  Google Scholar 

  • Olausson P, Jentsch JD, Taylor JR (2004) Nicotine enhances responding with conditioned reinforcement. Psychopharmacology 171:173–178

    Article  CAS  PubMed  Google Scholar 

  • Olausson P, Jentsch JD, Tronson N, Neve RL, Nestler EJ, Taylor JR (2006) ΔFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation. J Neurosci 26:9196–9204

    Article  CAS  PubMed  Google Scholar 

  • Oleson EB, Roberts DCS (2009) Behavioral economic assessment of price and cocaine consumption following self-administration histories that produce escalation of either final ratios or intake. Neuropsychopharmacology 34:796–804

    Article  PubMed  Google Scholar 

  • Orio L, Edwards S, George O, Parsons LH, Koob GF (2009) A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions. J Neurosci 29:4846–4857

    Article  CAS  PubMed  Google Scholar 

  • Park W-K, Bari AA, Jey AR, Spealman RD, Rowlett JK, Pierce RC (2002) Cocaine administered into the medial prefrontal cortex reinstates cocaine-seeking behavior by increasing AMPA receptor-mediated glutamate transmission in the nucleus accumbens. J Neurosci 22:2916–2925

    CAS  PubMed  Google Scholar 

  • Paterson NE, Markou A (2003) Increased motivation for self-administered cocaine after escalated cocaine intake. NeuroReport 14:2229–2232

    Article  CAS  PubMed  Google Scholar 

  • Paulson PE, Camp DM, Robinson TE (1991) Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats. Psychopharmacology 103:480–492

    Article  CAS  PubMed  Google Scholar 

  • Peris J, Zahniser NR (1987) One injection of cocaine produces a long-lasting increase in [3H]-dopamine release. Pharmacol Biochem Behav 27:533–535

    Article  CAS  PubMed  Google Scholar 

  • Piazza PV, Deminière J-M, Le Moal M, Simon H (1989) Factors that predict individual vulnerability to amphetamine self-administration. Science 245:1511–1513

    Article  CAS  PubMed  Google Scholar 

  • Piazza PV, Deminière J-M, Le Moal M, Simon H (1990) Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration. Brain Res 514:22–26

    Article  CAS  PubMed  Google Scholar 

  • Pierce RC, Kalivas PW (1997) A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Res Rev 25:192–216

    Article  CAS  PubMed  Google Scholar 

  • Pierce RC, Kumaresan V (2006) The mesolimbic dopamine system: The final common pathway for the reinforcing effect of drugs of abuse? Neurosci Biobehav Rev 30:215–238

    Article  CAS  PubMed  Google Scholar 

  • Pierce RC, Bell K, Duffy P, Kalivas PW (1996) Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization. J Neurosci 16:1550–1560

    CAS  PubMed  Google Scholar 

  • Pierre PJ, Vezina P (1997) Predisposition to self-administer amphetamine: the contribution of response to novelty and prior exposure to the drug. Psychopharmacology 129:277–284

    Article  CAS  PubMed  Google Scholar 

  • Pierre PJ, Vezina P (1998) D1 dopamine receptor blockade prevents the facilitation of amphetamine self administration induced by prior exposure to the drug. Psychopharmacology 138:159–166

    Article  CAS  PubMed  Google Scholar 

  • Ping A, Xi J, Prasad BM, Wang M-H, Kruzich PJ (2008) Contributions of nucleus accumbens core and shell GluR1 containing AMPA receptors in AMPA- and cocaine-primed reinstatement of cocaine-seeking behavior. Brain Res 1215:173–182

    Article  CAS  PubMed  Google Scholar 

  • Post RM, Rose H (1976) Increasing effects of repetitive cocaine administration in the rat. Nature 260:731–732

    Article  CAS  PubMed  Google Scholar 

  • Reid MS, Ciplet D, O’Leary S, Branchey M, Buydens-Branch AB (2004) Sensitization to the psychosis-inducing effects of cocaine compared with measures of cocaine craving and cue reactivity. Am J Addict 13:305–315

    Article  PubMed  Google Scholar 

  • Robinson TE (1984) Behavioral sensitization: characterization of enduring changes in rotational behavior produced by intermittent injections of amphetamine in male and female rats. Psychopharmacology 84:466–475

    Article  CAS  PubMed  Google Scholar 

  • Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Rev 18:247–291

    Article  CAS  PubMed  Google Scholar 

  • Robinson TE, Berridge KC (2000) The psychology and neurobiology of addiction: an incentive-sensitization view. Addiction 95(Suppl 2):S91–S117

    PubMed  Google Scholar 

  • Robinson TE, Berridge KC (2001) Incentive-sensitization and addiction. Addiction 96:103–114

    Article  CAS  PubMed  Google Scholar 

  • Robinson TE, Berridge KC (2003) Addiction. Ann Rev Psychol 54:25–53

    Article  Google Scholar 

  • Robinson TE, Berridge KC (2008) The incentive sensitization theory of addiction: some current issues. Phil Trans Royal Soc Lond B 363:3137–3146

    Article  Google Scholar 

  • Robinson TE, Becker JB, Presty SK (1982) Long-term facilitation of amphetamine-induced rotational behavior and striatal dopamine release produced by a single exposure to amphetamine: sex differences. Brain Res 253:231–241

    Article  CAS  PubMed  Google Scholar 

  • Rothman RB, Gorelick DA, Baumann MH, Guo XY, Herning RI, Pickworth WB, Gendron TM, Koeppl B, Thomson LE III, Henningfield JE (1994) Lack of evidence for context-dependent cocaine-induced sensitization in humans: preliminary studies. Pharmacol Biochem Behav 49:583–588

    Article  CAS  PubMed  Google Scholar 

  • Salamone JD, Correa M, Mingote SM, Weber SM (2005) Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine. Curr Opin Pharmacol 5:34–41

    Article  CAS  PubMed  Google Scholar 

  • Sato M, Chen C-C, Akiyama K, Otsuki S (1983) Acute exacerbation of paranoid psychotic state after long-term abstinence in patients with previous methamphetamine psychosis. Biol Psychiatry 18:429–440

    CAS  PubMed  Google Scholar 

  • Segal DS, Mandell AJ (1974) Long-term administration of d-amphetamine: progressive augmentation of motor activity and stereotypy. Pharmacol Biochem Behav 2:249–255

    Article  CAS  PubMed  Google Scholar 

  • Shaham Y, Shalev U, Lu L, De Wit H, Stewart J (2003) The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology 168:3–20

    Article  CAS  PubMed  Google Scholar 

  • Shippenberg TS, Heidbreder C (1995) Sensitization to the conditioned rewarding effects of cocaine: pharmacological and temporal characteristics. J Pharmacol Exp Ther 273:808–815

    CAS  PubMed  Google Scholar 

  • Shippenberg TS, Heidbreder Ch, Lefevour A (1996) Sensitization to the conditioned rewarding effects of morphine: pharmacology and temporal characteristics. Eur J Pharmacol 299:33–39

    Article  CAS  PubMed  Google Scholar 

  • Simpson GR, Riley AL (2005) Morphine preexposure facilitates morphine place preference and attenuates morphine taste aversion. Pharmacol Biochem Behav 80:471–479

    Article  CAS  PubMed  Google Scholar 

  • Strakowski SM, Sax KW (1998) Progressive behavioral response to repeated d-amphetamine challenge: further evidence for sensitization in humans. Biol Psychiatry 44:1171–1177

    Article  CAS  PubMed  Google Scholar 

  • Strakowski SM, Sax KW, Setters MJ, Keck PE (1996) Enhanced response to repeated d-amphetamine challenge: evidence for behavioral sensitization in humans. Biol Psychiatry 40:872–880

    Article  CAS  PubMed  Google Scholar 

  • Strakowski SM, Sax KW, Rosenberg HL, DelBello MP, Adler CM (2001) Human response to repeated low-dose d-amphetamine: Evidence for behavioral enhancement and tolerance. Neuropsychopharmacology 25:548–554

    Article  CAS  PubMed  Google Scholar 

  • Suto N, Austin JD, Tanabe LM, Kramer MK, Wright DA, Vezina P (2002) Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in a D1 dopamine receptor dependent manner. Neuropsychopharmacology 27:970–979

    Article  CAS  PubMed  Google Scholar 

  • Suto N, Tanabe L, Austin JD, Creekmore E, Vezina P (2003) Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in an NMDA, AMPA/kainate, and metabotropic glutamate receptor-dependent manner. Neuropsychopharmacology 28:629–639

    Article  CAS  PubMed  Google Scholar 

  • Suto N, Tanabe LM, Austin JD, Creekmore E, Pham CT, Vezina P (2004) Previous exposure to psychostimulants enhances the reinstatement of cocaine seeking by nucleus accumbens AMPA. Neuropsychopharmacology 29:2149–2159

    Article  CAS  PubMed  Google Scholar 

  • Sutton MA, Karanian DA, Self DW (2000) Factors that determine a propensity for cocaine-seeking behavior during abstinence in rats. Neuropsychopharmacology 22:626–641

    Article  CAS  PubMed  Google Scholar 

  • Taylor JR, Horger BA (1999) Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization. Psychopharmacology 142:31–40

    Article  CAS  PubMed  Google Scholar 

  • Taylor JR, Jentsch JD (2001) Repeated intermittent administration of psychomotor stimulant drugs alters the acquisition of pavlovian approach behavior in rats: Differential effects of cocaine, d-amphetamine and 3, 4-methylenedioxymethamphetamine (“ecstasy”). Biol Psychiatry 50:137–143

    Article  CAS  PubMed  Google Scholar 

  • Valadez A, Schenk S (1994) Persistence of the ability of amphetamine preexposure to facilitate acquisition of cocaine self-administration. Pharmacol Biochem Behav 47:203–205

    Article  CAS  PubMed  Google Scholar 

  • Vanderschuren LJMJ, Everitt BJ (2004) Drug seeking becomes compulsive after prolonged cocaine self-administration. Science 305:1017–1019

    Article  CAS  PubMed  Google Scholar 

  • Vanderschuren LJMJ, Kalivas PW (2000) Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies. Psychopharmacology 151:99–120

    Article  CAS  PubMed  Google Scholar 

  • Vanderschuren LJMJ, Tjon GHK, Nestby P, Mulder AH, Schoffelmeer ANM, De Vries TJ (1997) Morphine-induced long term sensitization to the locomotor effects of morphine and amphetamine depends on the temporal pattern of the pretreatment regimen. Psychopharmacology 131:115–122

    Article  CAS  PubMed  Google Scholar 

  • Vanderschuren LJMJ, Schmidt ED, De Vries TJ, Van Moorsel CAP, Tilders FJH, Schoffelmeer ANM (1999a) A single exposure to amphetamine is sufficient to induce long-term behavioral, neuroendocrine and neurochemical sensitization in rats. J Neurosci 19:9579–9586

    CAS  PubMed  Google Scholar 

  • Vanderschuren LJMJ, Schoffelmeer ANM, Mulder AH, De Vries TJ (1999b) Dopaminergic mechanisms mediating the long-term expression of locomotor sensitization following pre-exposure to morphine or amphetamine. Psychopharmacology 143:244–253

    Article  CAS  PubMed  Google Scholar 

  • Vanderschuren LJMJ, Schoffelmeer ANM, Mulder AH, De Vries TJ (1999c) Lack of cross-sensitization of the locomotor effects of morphine in amphetamine-treated rats. Neuropsychopharmacology 21:550–559

    Article  CAS  PubMed  Google Scholar 

  • Vanderschuren LJMJ, De Vries TJ, Wardeh G, Hogenboom FACM, Schoffelmeer ANM (2001) A single exposure to morphine induces long-lasting behavioral and neurochemical sensitization in rats. Eur J Neurosci 14:1533–1538

    Article  CAS  PubMed  Google Scholar 

  • Vezina P, Lorrain DS, Arnold GM, Austin JD, Suto N (2002) Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine. J Neurosci 22:4654–4662

    CAS  PubMed  Google Scholar 

  • Volkow ND, Wang GJ, Fowler JS, Logan J, Gatley SJ, Hitzemann R, Chen AD, Dewey SL, Pappas N (1997) Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects. Nature 386:830–833

    Article  CAS  PubMed  Google Scholar 

  • Wachtel SR, De Wit H (1999) Subjective and behavioral effects of repeated d-amphetamine in humans. Behav Pharmacol 10:271–281

    Article  CAS  PubMed  Google Scholar 

  • Ward SJ, Lack C, Morgan D, Roberts DCS (2006) Discrete-trials heroin self-administration produces sensitization to the reinforcing effects of cocaine in rats. Psychopharmacology 185:150–159

    Article  CAS  PubMed  Google Scholar 

  • Wee S, Mandyam CD, Lekic DM, Koob GF (2008) α1-Noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access. Eur Neuropsychopharmacol 18:303–311

    Article  CAS  PubMed  Google Scholar 

  • Wise RA, Bozarth MA (1987) A psychomotor stimulant theory of addiction. Psychol Rev 94:469–492

    Article  CAS  PubMed  Google Scholar 

  • Wyvell CL, Berridge CW (2001) Incentive sensitization by previous amphetamine exposure: increased cue-triggered “wanting” for sucrose reward. J Neurosci 21:7831–7840

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584, Utrecht, CG, The Netherlands

    Louk J. M. J. Vanderschuren

  2. Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    R. Christopher Pierce

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  1. Louk J. M. J. Vanderschuren
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  2. R. Christopher Pierce
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Correspondence to Louk J. M. J. Vanderschuren .

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Editors and Affiliations

  1. Southwestern Medical Center, University of Texas, Harry Hines Blvd. 5323, Dallas, 75390-9070, U.S.A.

    David W. Self

  2. School of Medicine, Yale University, Campell Ave. 950, West Haven, 06516, U.S.A.

    Julie K. Staley Gottschalk

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Vanderschuren, L.J.M.J., Pierce, R.C. (2010). Sensitization Processes in Drug Addiction. In: Self, D., Staley Gottschalk, J. (eds) Behavioral Neuroscience of Drug Addiction. Current Topics in Behavioral Neurosciences, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2009_21

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