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Axon Regeneration in the Peripheral and Central Nervous Systems

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Book cover Cell Biology of the Axon

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 48))

Abstract

Axon regeneration in the mature mammalian central nervous system (CNS) is extremely limited after injury. Consequently, functional deficits persist after spinal cord injury (SCI), traumatic brain injury, stroke, and related conditions that involve axonal disconnection. This situation differs from that in the mammalian peripheral nervous system (PNS), where long-distance axon regeneration and substantial functional recovery can occur in the adult. Both extracellular molecules and the intrinsic growth capacity of the neuron influence regenerative success. This chapter discusses determinants of axon regeneration in the PNS and CNS.

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  1. Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, USA

    Eric A. Huebner & Stephen M. Strittmatter

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  1. Eric A. Huebner
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  2. Stephen M. Strittmatter
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Correspondence to Stephen M. Strittmatter .

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    Edward Koenig

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Huebner, E.A., Strittmatter, S.M. (2009). Axon Regeneration in the Peripheral and Central Nervous Systems. In: Koenig, E. (eds) Cell Biology of the Axon. Results and Problems in Cell Differentiation, vol 48. Springer, Berlin, Heidelberg. https://doi.org/10.1007/400_2009_19

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