Abstract
We showed that a functional complex of CA4 and Na+/bicarbonate co-transporter (NBC1) is specifically expressed in the choriocapillaris and that mutations in CA4 disrupt NBC1-mediated HCO3 −- transport leading to acidification of the retina. This finding (Yang et al., 2005) point to the importance of a functional CA4 for the survival of photoreceptors and imply that CA inhibitors may have long-term adverse effects on vision.
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Sauvé, Y., Karan, G., Yang, Z., Li, C., Hu, J., Zhang, K. (2006). Treatment with Carbonic Anhydrase Inhibitors Depresses Electroretinogram Responsiveness in Mice. In: Hollyfield, J.G., Anderson, R.E., LaVail, M.M. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 572. Springer, Boston, MA. https://doi.org/10.1007/0-387-32442-9_61
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DOI: https://doi.org/10.1007/0-387-32442-9_61
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