Regular ArticleHypoxemia Alters Erythrocyte Perfusion Pattern in the Cerebral Capillary Network
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The capillary dysfunction hypothesis of Alzheimer's disease
2013, Neurobiology of AgingCitation Excerpt :This is supported by the high degrees of CTTH in the resting state (Jespersen and Østergaard, 2012), as calculated from the in vivo recordings of capillary erythrocyte velocities in rats (Kleinfeld et al., 1998; Pawlik et al., 1981; Villringer et al., 1994). In addition, hypercapnia, hypoxia, and cortical activation are accompanied by reductions in the heterogeneity of capillary flow velocities (Abounader et al., 1995; Hudetz et al., 1997; Krolo and Hudetz, 2000; Schulte et al., 2003; Stefanovic et al., 2008; Vogel and Kuschinsky, 1996). Under these conditions, the reductions in CTTH act in concert with increased CBF and changes in tissue oxygen tension to maintain a balance between oxygen availability and metabolic needs (Jespersen and Østergaard, 2012).
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
2008, NeuronCitation Excerpt :The former “capillary recruitment” hypothesis, proposing opening of new capillaries from an increase in the CBF and closing of brain capillaries from a decrease in the CBF (Weiss, 1988), has thus been modified to a “functional recruitment” hypothesis: brain capillaries are perfused all the time, but they transition from low to high blood flow with an increase in the CBF, or from high to low blood flow with a decrease in the CBF (Kuschinsky and Paulson, 1992). As shown in rodent models of brain hypoxemia, the major mechanisms raising the CBF are increased velocity of microvessel perfusion (Bereczki et al., 1993) and recruitment of red blood cells to the capillary networks (Krolo and Hudetz, 2000). The morphometric analysis of the mouse cortical vasculature in vivo based on two-photon imaging indicates that perfused capillaries (∼4–8 μm in diameter) and small arterioles and venules (10–60 μm in diameter) occupy between 3%–4% and 4%–6% of the brain volume, respectively.
Mathematical model for the estimation of hemodynamic and oxygenation variables by tissue spectroscopy
2006, Journal of Theoretical BiologyTemporal dynamics of the BOLD fMRI impulse response
2005, NeuroImageCortical electrical stimulation alters erythrocyte perfusion pattern in the cerebral capillary network of the rat
2003, Brain ResearchCitation Excerpt :The number of FRBCs residing in a capillary per unit time, the FRBC supply rate, was determined by counting the number of FRBCs passing through the same capillaries in which velocity was measured. Both FRBC velocity and supply rate were measured, because these quantities reflect slightly different aspects of capillary perfusion [6,19,22,32,50,52]. Theoretically, FRBC supply rate is a closer index of flow rate than velocity.
Arteriolar flow recruitment with vitronectin receptor stimulation linked to remote wall shear stress
2002, Microvascular Research