Regular Articlepp60c-src Is a Negative Regulator of Laminin-1-Mediated Neurite Outgrowth in Chick Sensory Neurons
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The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: The role of tumor necrosis factor-α
2010, Brain, Behavior, and ImmunityCitation Excerpt :However, whether and how activated microglia affects the synaptic plasticity mediated by afferent C-fibers is largely unknown. Src-family kinases (SFKs) are expressed widely throughout the mammalian central nervous system (CNS) and have been implicated in proliferation and differentiation in the developing CNS (Kuo et al., 1997; Hoffman-Kim et al., 2002). A recent study has shown that peripheral nerve injury activates SFKs only in microglia but not in neurons and astrocytes in spinal dorsal horn and that intrathecal administration of the SFKs inhibitor PP2 suppresses nerve injury-induced mechanical hypersensitivity (Katsura et al., 2006), suggesting SFKs in spinal microglia is critical for neuropathic pain.
Chromophore-Assisted Laser Inactivation
2007, Methods in Cell BiologyCitation Excerpt :CALI has helped to sort out the distinct functions of members of the myosin family (Diefenbach et al., 2002; Wang et al., 1996, 2003). It has elucidated the role of pp60c‐src in neurite outgrowth (Hoffman‐Kim et al., 2002), a role that a knockout mouse model was unable to resolve, likely because of functional compensation. Traditional CALI and double‐CALI served to determine the functions of two neural cell adhesion molecules, L1 and NCAM‐180, whose functions had been difficult to study in knockout models due to complications with adhesion (Takei et al., 1999).
Identification of neurite outgrowth-promoting domains of neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, and involvement of phosphatidylinositol 3-kinase and protein kinase C signaling pathways in neuritogenesis
2006, Journal of Biological ChemistryCitation Excerpt :Neither the protein level nor the phosphorylation level of ERK1/2 was changed remarkably by NGCect treatment of neurons (Fig. 4B). Next, we examined the involvement of Src family tyrosine kinases whose molecular sizes are 50-60 kDa, because they have been demonstrated to be involved in the elongation of neurites in some cases (18-20). However, the level of c-Src phosphorylation was not changed in neurons treated with NGCect (data not shown).
Direct Interaction of Focal Adhesion Kinase with p190RhoGEF
2003, Journal of Biological ChemistryCitation Excerpt :Because neurite outgrowth and guidance are mediated by the local control of actin dynamics, which in turn are regulated by Rho GTPases (40), our studies suggest a potential role for p190RhoGEF downstream of FAK activation in the control of these processes. Notably, recent studies have shown that chromophore-assisted laser inactivation of c-Src signaling complexes leads to neurite outgrowth of DRG neurons on laminin (41) and that RhoGEF-mediated activation of RhoA is associated with growth cone collapse (42). We hypothesize that FAK-specific signaling connections to p190RhoGEF may be involved in the local fine-tuning of Rho GTPase activity, which is essential for growth cone turning and guidance in response to extracellular cues.
Expressions of Src kinases in normal developing brain and immature brains with hypoxic-ischemic white matter injury of rats
2021, Fudan University Journal of Medical SciencesOptical manipulation of molecular function by chromophore-assisted light inactivation
2021, Proceedings of the Japan Academy Series B: Physical and Biological Sciences
- 1
These two authors shared equally in the work for this study.
- 2
Present address: Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Box G-B393, Providence, RI 02912
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To whom correspondence and reprint requests should be addressed. Fax: 617-636-0445. E-mail: [email protected].