Regular ArticleStrychnine-Blocked Glycine Receptor Is Removed from Synapses by a Shift in Insertion/Degradation Equilibrium
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Cited by (29)
In Vivo Measurement of Glycine Receptor Turnover and Synaptic Size Reveals Differences between Functional Classes of Motoneurons in Zebrafish
2017, Current BiologyCitation Excerpt :We did this for two functionally different cell types, PMNs and SMNs, to explore how receptor dynamics and synaptic size distributions differ in neurons driving fast versus slower motor outputs. The rates in vivo for PMNs (mean τ of 11.8 hr) were on the order of membrane-bound GlyR turnover measured in vitro (mean τ of 20.2 hr), from studies of picrotoxin-blocked ventral horn neurons in culture [29]. There are no in vivo studies of receptor turnover at individual central synapses.
Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex
2008, Molecular and Cellular NeuroscienceEndocytosis in Neurons
2007, Protein Trafficking in NeuronsEndocytosis in Neurons
2006, Protein Trafficking in NeuronsClustered and non-clustered GABA<inf>A</inf> receptors in cultured hippocampal neurons
2006, Molecular and Cellular NeuroscienceCitation Excerpt :The direct interaction of the GlyR β-IL subunit with gephyrin seems to be involved in the postsynaptic accumulation of the GlyR (Kirsch et al., 1993; Meyer et al., 1995). The GlyR–gephyrin interaction is important for the rate of surface accumulation, postsynaptic accumulation, postsynaptic stabilization and internalization of GlyRs from synapses to intracellular organelles (Kirsch et al., 1993; Feng et al., 1998; Rasmussen et al., 2002; Hanus et al., 2004; Levi et al., 2004). Furthermore, GlyR and Ca+ channel activity has also been shown to be important for GlyR surface stability and the postsynaptic accumulation of the glycine receptor (Kirsch and Betz, 1998; Levi et al., 1998; Kneussel and Betz, 2000).
Neurochemical basis for an epigenetic vision of synaptic organization
2004, International Review of Neurobiology
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