Gene structure |
The human gene is more than 171,000 base pairs in length and contains 16 exons |
The mouse homolog is 94,000 base pairs long and has 13 exons |
The rat homolog is 92,000 base pairs long and has 13 exons |
Homologues/orthologs identified in >190 vertebrate species |
>100 additional orthologs identified in nonvertebrate animal species |
Chromosome locations are on 15 in mouse, 8 in human, and 7 in rat |
mRNA transcripts |
3 verified and 5 predicted in human (H. sapiens) |
2 verified and 1 predicted in mouse (Mus musculus) |
1 verified and 5 predicted in rat (R. norvegicus) |
1 verified in Drosophila |
Proteins, domains, and motifs |
Proteins range in size from 16.5 to 133 kDa |
Domains include WW, MyTH4, and RhoGAP |
Additional predicted motifs include serine and threonine phosphorylation, SH3, and SH2 |