Subjective, autonomic, and endocrine stress response in Experiment II
| Control | Stress | |||
|---|---|---|---|---|
| Carriers | Noncarriers | Carriers | Noncarriers | |
| Subjective assessment | ||||
| Stressful | 29.17 ± 2.96 | 30.67 ± 6.28 | 65.80 ± 2.73 | 66.00 ± 5.24*** |
| Difficult | 26.67 ± 3.01 | 25.33 ± 6.61 | 71.80 ± 2.63 | 67.33 ± 6.93*** |
| Unpleasant | 34.38 ± 3.55 | 38.67 ± 7.61 | 66.40 ± 3.33 | 76.00 ± 5.42*** |
| Subjective mood | ||||
| Good vs bad mood | ||||
| Before treatment | 34.65 ± 0.62 | 33.93 ± 1.09 | 34.84 ± 0.49 | 33.07 ± 1.37 |
| 1 min after treatment | 34.13 ± 0.59 | 33.27 ± 1.24 | 28.31 ± 0.92 | 28.53 ± 1.73*** |
| 75 min after treatment | 33.21 ± 0.68 | 31.07 ± 1.44 | 31.80 ± 0.70 | 29.27 ± 1.74 |
| Calm vs restless | ||||
| Before treatment | 31.83 ± 0.79 | 33.20 ± 0.91 | 32.26 ± 0.72 | 29.87 ± 1.33 |
| 1 min after treatment | 30.63 ± 0.81 | 30.33 ± 1.67 | 24.61 ± 0.93 | 23.53 ± 1.60*** |
| 75 min after treatment | 31.63 ± 0.77 | 32.53 ± 1.33 | 32.38 ± 0.72 | 30.73 ± 0.91 |
| Tired vs awake | ||||
| Before treatment | 31.17 ± 0.79 | 27.67 ± 1.56 | 31.14 ± 0.65 | 28.13 ± 1.37 |
| 1 min after treatment | 30.46 ± 0.85 | 27.20 ± 1.58 | 29.61 ± 0.69 | 25.80 ± 1.62 |
| 75 min after treatment | 24.65 ± 0.78 | 19.67 ± 1.41 | 22.88 ± 0.86 | 20.47 ± 1.17 |
| Overall tired vs awake | 31.36 ± 0.65 | 32.02 ± 1.15 | 29.73 ± 0.64 | 28.04 ± 1.15## |
| Systolic blood pressure (bpm) | ||||
| Before treatment | 124.09 ± 1.97 | 124.00 ± 2.84 | 122.19 ± 1.90 | 123.83 ± 3.67 |
| During treatment | 119.05 ± 1.89 | 119.73 ± 3.92 | 128.68 ± 2.14 | 127.17 ± 4.42** |
| 5 min after treatment | 120.04 ± 1.83 | 121.83 ± 3.99 | 129.39 ± 2.06 | 128.33 ± 3.81** |
| 75 min after treatment | 121.52 ± 1.77 | 118.97 ± 2.76 | 119.55 ± 1.88 | 127.20 ± 2.61+ |
| Diastolic blood pressure (bpm) | ||||
| Before treatment | 83.25 ± 1.34 | 82.07 ± 2.53 | 81.21 ± 0.97 | 84.90 ± 2.79 |
| During treatment | 83.24 ± 1.17 | 82.50 ± 2.26 | 89.59 ± 1.49 | 95.03 ± 3.58*** |
| 5 min after treatment | 84.07 ± 1.26 | 83.53 ± 1.83 | 88.05 ± 1.26 | 90.47 ± 3.08** |
| 75 min after treatment | 84.35 ± 1.42 | 83.03 ± 1.78 | 82.90 ± 1.13 | 86.83 ± 2.51 |
| Salivary cortisol (nmol/l) | ||||
| Before treatment | 3.37 ± 0.69 | 3.66 ± 1.24 | 3.68 ± 0.68 | 6.71 ± 1.242 |
| 5 min after treatment | 3.62 ± 0.93 | 3.78 ± 1.67 | 7.03 ± 0.91 | 12.43 ± 1.67*** |
| 15 min after treatment | 3.31 ± 0.98 | 3.66 ± 1.75 | 8.91 ± 0.96 | 13.80 ± 1.75*** |
| 75 min after treatment | 2.46 ± 0.62 | 2.85 ± 1.12 | 4.16 ± 0.61 | 7.44 ± 1.12*** |
| Overall salivary cortisol (nmol/l) | 3.19 ± 0.75 | 3.48 ± 1.34 | 5.94 ± 0.73 | 10.10 ± 1.34# |
Data represent means ± SEM. bpm, beats per minute. Time × treatment (stress vs control) interaction ***p < 0.001 and **p < 0.01. MR haplotype (carriers vs noncarriers) main effect ##p < 0.01 and #p < 0.05. Time × treatment × MR haplotype interaction +p < 0.05.