Passive and active electrical properties of LS bladder sensory neurons from rats transduced with AdGFP or AdCldn2
| GFP | Cldn2 | |||
|---|---|---|---|---|
| TTX-S | TTX-R | TTX-S | TTX-R | |
| Number of cells RMP (mV) | n = 23 −64.8 ± 1.1 | n = 36 −63.6 ± 0.9 | n = 18 −57.9 ± 1.6** | n = 29 −62.1 ± 1.1 |
| Cm (pF) | 30.8 ± 2.6 | 29.7 ± 1.8 | 30.1 ± 2.5 | 29.1 ± 1.3 |
| RIn (GΩ) | 0.88 ± 0.08 | 1.15 ± 0.09 | 0.83 ± 0.10 | 1.04 ± 0.08 |
| AP threshold (mV) | −29.1 ± 0.7 | −22.2 ± 0.5 | −34.2 ± 0.7*** | −23.8 ± 0.8 |
| AP duration (ms) | 3.5 ± 0.2 | 6.3 ± 0.4 | 4.1 ± 0.5 | 5.9 ± 0.7 |
| AP overshoot (mV) | 32.0 ± 2.8 | 38.0 ± 2.7 | 30.5 ± 3.7 | 40.0 ± 2.5 |
| Rheobase (pA) | 300 ± 45 | 393 ± 34 | 159 ± 38* | 361 ± 45 |
| AHP mag (mV) | −10.8 ± 1.2 | −10.1 ± 0.8 | −12.1 ± 1.6 | −10.3 ± 0.6 |
↵Values are means ± SEM. Statistically significant differences compared with control (GFP) are indicated as *p < 0.05, **p < 0.01, and ***p < 0.001 (unpaired t test with Welch’s correction). RMP, resting membrane potential; Cm, membrane capacitance; RIn, input resistance; AP, action potential; AHP mag, magnitude of hyperpolarization below the resting membrane potential.