Table 1.

Action potential waveform and membrane properties values of GFP+ DG neurons

Group 1Group 2Group 3
SalineMETHSalineMETHSalineMETH
AP peak (mV)*−0.97 ± 1.70−0.72 ± 4.2834.59 ± 2.2640.95 ± 1.7045.27 ± 1.7246.18 ± 2.50
AP amplitude (mV)*29.38 ± 3.1030.25 ± 5.9980.57 ± 3.8685.83 ± 2.8195.24 ± 1.4794.43 ± 2.94
AP area (mV · ms)78.71 ± 3.6375.44 ± 6.6891.27 ± 5.4284.50 ± 7.3692.91 ± 2.9785.47 ± 3.84
Half-width (ms)*3.38 ± 0.453.35 ± 0.690.98 ± 0.100.79 ± 0.060.85 ± 0.040.79 ± 0.05
Cm (pF)*21.66 ± 0.7719.96 ± 1.1840.02 ± 3.2142.39 ± 7.3256.00 ± 3.1349.96 ± 3.22
Rin (GΩ)*2.32 ± 0.162.35 ± 0.180.68 ± 0.110.92 ± 0.150.38 ± 0.030.36 ± 0.03
RMP (mV)*−38.00 ± 1.76−36.25 ± 4.09−62.01 ± 3.39−58.79 ± 2.87−68.17 ± 1.20−69.21 ± 1.53
  • Values are given as the mean ± SEM. METH induced no effect in all parameters analyzed. Cm, membrane capacitance; Rin, input resistance; RMP, resting membrane potential.

  • *Significantly different, using Kruskal–Wallis test followed by Dunn’s post hoc test or Bonferroni’s post hoc test. Asterisks correspond to statistical significance (p < 0.05) between group 1 and group 2 GFP+ DGCs, and between group 2 and group 3 GFP+ DGCs in saline conditions.