Statistical results for Morris water maze (MWM) acquisition performance in Fmr1 and WT mice
| Effect | Data structure | Type of test | Power | df (between) | df (within) | F | P |
|---|---|---|---|---|---|---|---|
| MWM acquisition latency-genotype | Sphericity violated | Mixed-model ANOVA | 0.19 | 1 | 22 | 1.31 | 0.3 |
| MWM acquisition latency-day | Sphericity violated | Mixed-model ANOVA with Greenhouse–Geisser correction | 1.00 | 4.63 | 101.95 | 25.73 | 5.55E-16 |
| MWM acquisition latency-interaction | Sphericity violated | Mixed-model ANOVA with Greenhouse–Geisser correction | 0.26 | 4.63 | 101.95 | 0.61 | 0.7 |
| MWM acquisition distance-genotype | Sphericity passed | Mixed-model ANOVA | 0.12 | 1 | 22 | 0.62 | 0.4 |
| MWM acquisition distance-day | Sphericity passed | Mixed-model ANOVA | 1.00 | 7 | 154 | 16.26 | 6.66E-16 |
| MWM acquisition distance-interaction | Sphericity passed | Mixed-model ANOVA | 0.36 | 7 | 154 | 0.85 | 0.5 |
| MWM acquisition speed-genotype | Sphericity violated | Mixed-model ANOVA | 0.32 | 1 | 22 | 2.47 | 0.1 |
| MWM acquisition speed-day | Sphericity violated | Mixed-model ANOVA with Greenhouse–Geisser correction | 1.00 | 4.49 | 98.82 | 9.64 | 0.0000005 |
| MWM acquisition speed-interaction | Sphericity violated | Mixed-model ANOVA with Greenhouse–Geisser correction | 0.29 | 4.49 | 98.82 | 0.69 | 0.6 |
| WT quadrant time | Sphericity passed | Repeated-measures ANOVA with post hoc Dunnett’s test | 0.97 | 3 | 33 | 7.19 | 0.0008 |
| FMR1 quadrant time | Sphericity violated | Repeated-measures ANOVA with Greenhouse–Geisser correction and post hoc Dunnett’s test | 1.00 | 1.65 | 18.16 | 25.04 | 0.00001 |
| WT platform crossings | Sphericity passed | Repeated-measures ANOVA with post hoc Dunnett’s test | 0.99 | 3 | 33 | 12.54 | 0.00001 |
| FMR1 platform crossings | Sphericity violated | Repeated-measures ANOVA with Greenhouse–Geisser correction and post hoc Dunnett’s test | 1.00 | 1.36 | 14.98 | 28.16 | 0.00003 |