Table 7.

Statistics

DatasetData structureType of testp value
a Fig. 1B. Active lever presses (saline-treated vs self-administering mice)Normal distributionTwo-way ANOVA<0.0001
b Fig. 1D. Active vs total lever presses in saline-treated miceNormal distributionTwo-way ANOVA<0.0001
c Fig. 1E. Drug reinforcers (saline-treated vs self-administering mice)Normal distributionTwo-way ANOVA<0.0001
dIncubation effect of amphetamine challenge in self-administering miceNormal distributionpaired t test0.01
e Fig. 1F. Active lever presses (self-administering mice without and with amphetamine and nicotine)Normal distributionpaired t test0.02
f Fig. 1I. Cue reinforcers (self-administering mice without and with amphetamine and nicotine)Normal distributionpaired t test0.02
g Fig. 1G. Number of inactive lever presses (self-administering mice treated with amphetamine vs self-administering mice treated with amphetamine and nicotine)Normal distributionpaired t test0.07
h Fig. 1H. Percentage ratio of active/total lever presses (self-administering mice treated with amphetamine vs self-administering mice treated with amphetamine and nicotine)Normal distributionpaired t test0.15
i Fig. 2A. Baseline firing frequency (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.03
Fig. 2B. Peak firing frequency power (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.02
Fig. 2D. Peak firing frequency distribution (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.02
j Fig. 2E. Firing frequency in saline-treated mice (vehicle vs amphetamine)Normal distributionpaired t test0.006
k Fig. 2F. Firing frequency in self-administering mice (vehicle vs amphetamine)Normal distributionpaired t test0.04
p Fig. 2E. Firing frequency in saline-treated mice (vehicle vs amphetamine with nicotine)Normal distributionpaired t test0.3
Fig. 2E. Firing frequency in saline-treated mice (amphetamine vs amphetamine with nicotine)Normal distributionpaired t test0.04
q Fig. 2F. Firing frequency in self-administering mice (vehicle vs amphetamine with nicotine)Normal distributionpaired t test0.3
Fig. 2F. Firing frequency in self-administering mice (amphetamine vs amphetamine with nicotine)Normal distributionpaired t test0.08
Fig. 2H. Peak firing frequency distribution in saline-treated mice (vehicle vs amphetamine)Normal distributionpaired t test0.03
Fig. 2H. Peak firing frequency distribution in saline-treated mice (vehicle vs amphetamine with nicotine)Normal distributionpaired t test0.3
Fig. 2H. Peak firing frequency distribution in saline-treated mice (amphetamine vs amphetamine with nicotine)Normal distributionpaired t test0.1
Fig. 2I. Peak firing frequency distribution in self-administering mice (vehicle vs amphetamine)Normal distributionpaired t test0.008
Fig. 2I. Peak firing frequency distribution in self-administering mice (vehicle vs amphetamine with nicotine)Normal distributionpaired t test0.09
Fig. 2I. Peak firing frequency distribution in self-administering mice (amphetamine vs amphetamine with nicotine)Normal distributionpaired t test0.04
Fig. 2J. Peak firing frequency distribution (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.09
r Fig. 3C. Discrete bursting (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.03
Fig. 3D. Intra-burst frequency (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.7
s Fig. 3D. Burst length in saline-treated mice (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.03
t Fig. 3D. Time bursting (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.009
Fig. 3E. Discrete pausing (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.5
Fig. 3F. Intra-pause frequency (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.2
Fig. 3F. Pause string length (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.8
Fig. 3F. Time pausing (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.4
Fig. 3G. Rate of burst and pause pattern occurrence (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.2
Fig. 3H. Rate of pause and burst pattern occurrence (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.02
Fig. 3I. Rate of burst-pause-burst pattern occurrence (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.03
u Fig. 4A. Discrete bursting in saline-treated mice (vehicle vs amphetamine)Normal distributionPaired t test0.02
Fig. 4A. Discrete bursting in saline-treated mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.5
Fig. 4A. Discrete bursting in saline-treated mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.2
Fig. 4B. Intra-burst frequency in saline-treated mice (vehicle vs amphetamine)Normal distributionPaired t test0.2
Fig. 4B. Intra-burst frequency in saline-treated mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.1
Fig. 4B. Intra-burst frequency in saline-treated mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.3
Fig. 4B. Burst length in saline-treated mice (vehicle vs amphetamine)Normal distributionPaired t test0.1
Fig. 4B. Burst length in saline-treated mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.2
Fig. 4B. Burst length in saline-treated mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.09
Fig. 4B. Time spent bursting in saline-treated mice (vehicle vs amphetamine)Normal distributionPaired t test0.4
Fig. 4B. Time spent bursting in saline-treated mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.7
Fig. 4B. Time spent bursting in saline-treated mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.5
Fig. 4C. Discrete pausing in saline-treated mice (vehicle vs amphetamine)Normal distributionPaired t test0.2
Fig. 4C. Discrete pausing in saline-treated mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.3
Fig. 4C. Discrete pausing in saline-treated mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.1
Fig. 4D. Intra-pause frequency in saline-treated mice (vehicle vs amphetamine)Normal distributionPaired t test0.4
Fig. 4D. Intra-pause frequency in saline-treated mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.6
Fig. 4D. Intra-pause frequency in saline-treated mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.2
Fig. 4D. Pause string length in saline-treated mice (vehicle vs amphetamine)Normal distributionPaired t test0.06
Fig. 4D. Pause string length in saline-treated mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.2
Fig. 4D. Pause string length in saline-treated mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.1
Fig. 4D. Time spent pausing in saline-treated mice (vehicle vs amphetamine)Normal distributionPaired t test0.2
Fig. 4D. Time spent pausing in saline-treated mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.2
Fig. 4D. Time spent pausing in saline-treated mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.4
Fig. 4E. Discrete bursting in self-administering mice (vehicle vs amphetamine)Normal distributionPaired t test0.6
Fig. 4E. Discrete bursting in self-administering mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.6
Fig. 4E. Discrete bursting in self-administering mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.7
Fig. 4F. Intra-burst frequency in self-administering mice (vehicle vs amphetamine)Normal distributionPaired t test0.1
Fig. 4F. Intra-burst frequency in self-administering mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.07
Fig. 4F. Intra-burst frequency in self-administering mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.1
Fig. 4F. Burst length in self-administering mice (vehicle vs amphetamine)Normal distributionPaired t test0.1
Fig. 4F. Burst length in self-administering mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0. 08
Fig. 4F. Burst length in self-administering mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.007
Fig. 4F. Time spent bursting in self-administering mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.9
Fig. 4F. Time spent bursting in self-administering mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.8
Fig. 4F. Time spent bursting in self-administering mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.1
v Fig. 4G. Discrete pausing in self-administering mice (vehicle vs amphetamine)Normal distributionPaired t test0.04
Fig. 4G. Discrete pausing in self-administering mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.09
Fig. 4G. Discrete pausing in self-administering mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.5
w Fig. 4H. Intra-pause frequency in self-administering mice (vehicle vs amphetamine)Normal distributionPaired t test0.03
Fig. 4H. Intra-pause frequency in self-administering mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.4
Fig. 4H. Intra-pause frequency in self-administering mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.1
Fig. 4H. Pause string length in self-administering mice (vehicle vs amphetamine)Normal distributionPaired t test0.1
Fig. 4H. Pause string length in self-administering mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.1
Fig. 4H. Pause string length in self-administering mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.5
x Fig. 4H. Time spent pausing in self-administering mice (vehicle vs amphetamine)Normal distributionPaired t test0.04
Fig. 4H. Time spent pausing in self-administering mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.08
Fig. 4H. Time spent pausing in self-administering mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.2
Fig. 5A. Chl frequency (saline-treated vs self-administering mice)Normal distributionStudent’s t test0.03
y Fig. 5A. Chl frequency in saline-treated mice (vehicle vs nicotineNormal distributionPaired t test0.03
z Fig. 5A. Chl frequency in self-administering mice (vehicle vs nicotine)Normal distributionPaired t test0.04
Fig. 5C. Peak frequency in saline-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.03
Fig. 5D. Peak frequency in saline-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.04
Fig. 5E. Peak frequency in saline-treated mice (vehicle vs nicotine)Normal distributionStudent’s t test0.02
aa Fig. 5F. Discrete bursting in saline-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.02
Fig. 5G. Intra-burst frequency in saline-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.5
Fig. 5G. Burst length in saline-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.2
ab Fig. 5G. Time bursting in saline-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.01
ac Fig. 5H. Discrete pausing in saline-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.04
Fig. 5I. Intra-pause frequency in saline-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.08
Fig. 5I. Pause length in saline-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.7
Fig. 5I. Time pausing in saline-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.1
ad Fig. 5J. Discrete bursting in self-administering mice (vehicle vs nicotine)Normal distributionPaired t test0.0008
Fig. 5K. Intra-burst frequency in self-administering mice (vehicle vs nicotine)Normal distributionPaired t test0.4
Fig. 5K. Burst length in self-administering mice (vehicle vs nicotine)Normal distributionPaired t test0.5
ae Fig. 5K. Time bursting in self-administering mice (vehicle vs nicotine)Normal distributionPaired t test0.01
af Fig. 5L. Discrete pausing in self-administering mice (vehicle vs nicotine)Normal distributionPaired t test0.02
ag Fig. 5M. Intra-pause frequency in self-administering mice (vehicle vs nicotine)Normal distributionPaired t test0.02
ah Fig. 5M. Pause length in self-administering mice (vehicle vs nicotine)Normal distributionPaired t test0.02
Fig. 5M. Time pausing in saline-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.1
ai Fig. 6A. mEPSC frequency (saline-treated mice vs self-administering mice)Normal distributionStudent’s t test0.04
aj Fig. 6A. mEPSC frequency (saline-treated mice vs nonresponding mice)Normal distributionStudent’s t test0.003
ak Fig. 6A. mEPSC frequency (self-administering mice vs nonresponding mice)Normal distributionStudent’s t test0.0003
Fig. 6B. mEPSC frequency (saline-treated mice vs self-administering mice)Normal distributionBonferroni t test0.00003
Fig. 6B. mEPSC frequency (saline-treated mice vs nonresponding mice)Normal distributionBonferroni t test0.002
Fig. 6C. Peak frequency of mEPSCs (saline-treated mice vs self-administering mice)Normal distributionStudent’s t test0.009
Fig. 6C. Peak frequency of mEPSCs (saline-treated mice vs nonresponding mice)Normal distributionStudent’s t test0.006
Fig. 6C. Peak frequency of mEPSCs (self-administering mice vs nonresponding mice)Normal distributionStudent’s t test0.0008
al Fig. 6D. mEPSC frequency in saline-treated mice (vehicle vs amphetamine)Normal distributionPaired t test0.04
an Fig. 6D. mEPSC frequency in saline-treated mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.01
am Fig. 6D. mEPSC frequency in saline-treated mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.04
Fig. 6E. mEPSC frequency in saline-treated mice (vehicle vs amphetamine)Normal distributionBonferroni t test0.04
Fig. 6E. mEPSC frequency in saline-treated mice (vehicle vs amphetamine with nicotine)Normal distributionBonferroni t test0.01
Fig. 6E. mEPSC frequency in saline-treated mice (amphetamine vs amphetamine with nicotine)Normal distributionBonferroni t test0.09
Fig. 6F. Peak frequency of mEPSCs in saline-treated mice (vehicle vs amphetamine)Normal distributionPaired t test0.7
Fig. 6F. Peak frequency of mEPSCs in saline-treated mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.3
Fig. 6F. Peak frequency of mEPSCs in saline-treated mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.2
ao Fig. 6G. mEPSC frequency in self-administering mice (vehicle vs amphetamine)Normal distributionPaired t test0.004
ap Fig. 6G. mEPSC frequency in self-administering mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.006
Fig. 6H. mEPSC frequency in self-administering mice (vehicle vs amphetamine)Normal distributionBonferroni t test0.04
Fig. 6H. mEPSC frequency in self-administering mice (vehicle vs amphetamine with nicotine)Normal distributionBonferroni t test0.008
Fig. 6H. mEPSC frequency in self-administering mice (amphetamine vs amphetamine with nicotine)Normal distributionBonferroni t test0.03
Fig. 6I. Peak frequency of mEPSCs in self-administering mice (vehicle vs amphetamine)Normal distributionPaired t test0.1
Fig. 6I. Peak frequency of mEPSCs in self-administering mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.09
Fig. 6I. Peak frequency of mEPSCs in self-administering mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.04
Fig. 6J. Peak frequency of mEPSCs (saline-treated mice vs self-administering mice with nicotine)Normal distributionStudent’s t test0.3
aq Fig. 6K. mEPSC frequency in nonresponding mice (vehicle vs amphetamine)Normal distributionPaired t test0.003
ar Fig. 6K. mEPSC frequency in nonresponding mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.02
Fig. 6L. mEPSC frequency in nonresponding mice (vehicle vs amphetamine)Normal distributionBonferroni t test0.003
Fig. 6L. mEPSC frequency in nonresponding mice (vehicle vs amphetamine with nicotine)Normal distributionBonferroni t test0.0002
Fig. 6L. mEPSC frequency in nonresponding mice (amphetamine vs amphetamine with nicotine)Normal distributionBonferroni t test0.03
Fig. 6M. Peak frequency of mEPSCs in nonresponding mice (vehicle vs amphetamine)Normal distributionPaired t test0.02
Fig. 6M. Peak frequency of mEPSCs in nonresponding mice (vehicle vs amphetamine with nicotine)Normal distributionPaired t test0.02
Fig. 6M. Peak frequency of mEPSCs in nonresponding mice (amphetamine vs amphetamine with nicotine)Normal distributionPaired t test0.2
as Fig. 7A. mEPSC frequency in saline-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.04
Fig. 7B. mEPSC frequency in saline-treated mice (vehicle vs nicotine)Normal distributionBonferroni t test0.04
Fig. 7C. Peak frequency of mEPSCs in saline-treated mice (vehicle vs amphetamine)Normal distributionPaired t test0.7
at Fig. 7D. mEPSC frequency in self-administering mice (vehicle vs nicotine)Normal distributionPaired t test0.03
Fig. 7E. mEPSC frequency in self-administering mice (vehicle vs nicotine)Normal distributionBonferroni t test0.04
Fig. 7F. Peak frequency of mEPSCs in self-administering mice (vehicle vs amphetamine)Normal distributionPaired t test0.1
Fig. 7G. mEPSC frequency in saline-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.04
au Fig. 7G. mEPSC frequency (saline-treated mice vs self-administering mice)Normal distributionStudent’s t test0.002
av Fig. 7G. mEPSC frequency in self-administering mice (vehicle vs nicotine)Normal distributionPaired t test0.02
Fig. 7H. mEPSC frequency (saline-treated mice vs self-administering mice with nicotine)Normal distributionStudent’s t test0.2
aw Fig. 7I. mEPSC frequency in saline-treated mice (vehicle vs nicotine with DHβE)Normal distributionPaired t test0.04
Fig. 7J. mEPSC frequency in saline-treated mice (vehicle vs nicotine with DHβE)Normal distributionBonferroni t test0.03
ax Fig. 7K. mEPSC frequency in saline-treated mice (vehicle vs nicotine with MLA)Normal distributionPaired t test0.04
Fig. 7L. mEPSC frequency in saline-treated mice (vehicle vs nicotine with MLA)Normal distributionBonferroni t test0.009
ay Fig. 8B. Ambulations of saline-treated mice vs amphetamine-treated miceNormal distributionrm ANOVA0.0001
az Fig. 8C. Ambulations of saline-treated mice vs amphetamine-treated miceNormal distribution2-way rm-ANOVA0.0001
ba Fig. 8D. Ambulations of saline-treated mice (low-dose vs high-dose nicotine)Normal distribution2-way rm-ANOVA0.9
bb Fig. 8E. Ambulations of amphetamine-treated mice (amphetamine vs amphetamine with low-dose nicotine)Normal distribution2-way rm-ANOVA1
bc Fig. 8E. Ambulations of amphetamine-treated mice (amphetamine vs amphetamine with high-dose nicotine)Normal distribution2-way rm-ANOVA0.01
bd Fig. 8F. Ambulations of saline-treated mice (amphetamine vs amphetamine with high-dose nicotine)Normal distribution2-way rm-ANOVA0.9
be Fig. 8G. Ambulations of saline-treated mice challenged with nicotine vs amphetamine-treated mice challenged with nicotineNormal distribution2-way rm-ANOVA0.9
bf Fig. 8H. eEPSC amplitude in saline-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.02
bg Fig. 8H. PPR in saline-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.009
bh Fig. 8I. eEPSC amplitude in amphetamine-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.0008
bi Fig. 8I. PPR in amphetamine-treated mice (vehicle vs nicotine)Normal distributionPaired t test0.013
bj Fig. 8H,I. eEPSC amplitude (saline-treated mice vs amphetamine-treated mice)Normal distributionStudent’s t test0.02
bk Fig. 8H,I. eEPSC amplitude (saline-treated mice with nicotine vs amphetamine-treated mice with nicotine)Normal distributionStudent’s t test0.2