Effects of stimulation on number of nonsynaptic NMDA receptor islands in neuronal plasma membranes
| Control | 2 Min high K+ | 2 Min K+ + 2-3 min recovery | 2 Min K+ + 30 min recovery | |
|---|---|---|---|---|
| Exp 1 | 11.8 (17) | 38.5 (26) | 12.5 (40) | |
| Exp 2 | 13.0 (23) | 35.0 (20) | 16.0 (25) | |
| Exp 3 | 10.3 (29) | 68.1 (47) | 18.5 (27) | 18.2 (22) |
| Exp 4 | 5.0 (20) | 57.7 (26) | 11.5 (26) | 16.2 (37) |
| Mean ± SEM | 10.0 ± 1.8 | 49.8 ± 7.9* | 14.2 ± 2.2 | 16.2 ± 0.7 |
Data are reported as number of islands per 100 somal profiles (n, Number of neuroanls somal profiles scored).
*The number of islands is significantly higher in high K+ vs. control (P < 0.0005), high K+ vs. 2 min K++2-3 min recovery (P < 0.005) and high K+ vs. 2 min K++30 min recovery (P < 0.005); ANOVA with Tukey’s post-test.