Table 2

Estradiol-induced PR-ir cells in the VMN and MPA that express coactivators have greater immunostaining intensity than PR-ir cells that lack coactivators

Brain regionGenotypePR only cellsPR cells
SRC-1 and SRC-2
PR cells
SRC-1
PR cells
SRC-2
VMNwt22 ± 1.939 ± 6.7*30 ± 3.637 ± 4.7*
PRBKO22 ± 336 ± 7.128 ± 434 ± 5.1*
PRAKO17 ± 3.116 ± 1.415 ± 0.916 ± 1.2
ARCwt24 ± 1.428 ± 2.124 ± 1.527 ± 1.2
PRBKO34 ± 8.925 ± 1.223 ± 1.229 ± 5.4
MPAwt18 ± 1.125 ± 1.8*22 ± 1.3*22 ± 1.3*
  • Values are given as the mean intensity ± SEM. In the VMN of wt and PRBKO mice, PR-ir cells that express SRC-2 have greater immunostaining intensity than PR-ir cells that lack SRC-2. In the MPA of wt mice, estradiol-induced PR-ir cells that express SRC-1 and/or SRC-2 have higher immunostaining intensity than PR-ir cells lacking these coactivators.

  • *p < 0.05, for differences between PR-only cell types.