Linear variables of the skull in WT and Srcthl/thl mice
| Measurement | Wildtype | Srcthl/thl | p value | ||
|---|---|---|---|---|---|
| Mean | SEM | Mean | SEM | ||
| Ps-Rh | 145.1 | 1.4 | 117.6 | 4.2 | 0.0008 |
| Op-Ne | 235.5 | 1.3 | 200.8 | 5.2 | 0.0007 |
| Na-Rh | 111.3 | 1.8 | 91.0 | 3.4 | 0.0018 |
| Go-Mn | 56.5 | 3.6 | 49.9 | 3.7 | 0.24 |
| Ps-Na | 77.8 | 0.9 | 65.5 | 1.3 | 0.00024 |
| Ps-Ba | 110.5 | 2.1 | 97.5 | 2.7 | 0.0092 |
| Mx1-Mx2 | 61.0 | 0.6 | 56.0 | 2.3 | 0.077 |
| Cw1-Cw2 | 117.3 | 0.5 | 110.8 | 1.9 | 0.017 |
| Op-Inc | 261.4 | 0.7 | 221.0 | 6.9 | 0.0011 |
| Ps-Inc | 113.1 | 1.4 | 94.4 | 5.1 | 0.013 |
Nine-week old male mice (n =2 WT, n= 2 Srcthl/thl ) were dissected to obtain the skull for faxitron analysis. Images were printed at the same magnification and the distances between established landmarks measured. Data are presented as mean ± SEM.
Lateral cephalometric landmarks: Ba: basion, the most posterior point of occipital bone anterior to the foramen magnum; Cw1 and Cw2: most lateral points of the calvarium; Go: gonion, the most posterior point of the mandibular angular process; Mn: point in the deepest part of the antegonial notch curvature; Mx1 and Mx2: most anterior and posterior points of the maxilla; Na: nasion, the junction of the frontonasal and internasal sutures; Ne: nasale, intersection of nasal bones, rostral point; Ps: pre-sphenoid, the middle of the presphenoethmoidal synchrondrosis; Inc: incisor, the most prominent point between incisal edges of lower incisors.
Dorsoventral cephalometric landmarks: Rh: rhinion, the most anterior point of the nasal bones in the midline; Op: opisthion, midsaggital point on the posterior margin of the foramen magnum.