Offspring included in behavior testing | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Total number | PPI | CMOR | Sociability | Oddity preference | Locomotor activity | |||||||
Treatment | Rats | Litters | Rats | Litters | Rats | Litters | Rats | Litters | Rats | Litters | Rats | Litters |
Saline | 36 | 15 | 36 | 15 | 22 | 15 | 22 | 15 | 22 | 15 | 14 | 11 |
PolyI:C | 35 | 16 | 35 | 15 | 24 | 15 | 24 | 15 | 24 | 15 | 20 | 13 |
Number of litters with n = 5 or fewer offspring included in PPI | ||||||||||||
Treatment | n = 5 | n = 4 | n = 3 | n = 2 | n = 1 | |||||||
Saline | 1 | 5 | 1 | 0 | 8 | |||||||
PolyI:C | 1 | 0 | 7 | 1 | 7 | |||||||
Number of litters with n = 1 or n = 2 offspring in CMOR, sociability, and oddity | ||||||||||||
Treatment | n = 2 | n = 1 | ||||||||||
Saline | 7 | 8 | ||||||||||
PolyI:C | 9 | 6 | ||||||||||
Number of litters with n = 1 or n = 2 offspring tested in MK-801-induced locomotor activity | ||||||||||||
Treatment | n = 2 | n = 1 | ||||||||||
Saline | 3 | 8 | ||||||||||
PolyI:C | 7 | 6 |
All female offspring from n = 31 litters completed PPI, while all other tasks included one or two offspring per litter. The unexpected death of one polyI:C rat with no female littermates reduced the number of litters tested to 15. Locomotor activity n was reduced due to some rats being diverted to concurrent research. The number of offspring per litter in each task is further summarized below. behavior scores for littermates were averaged for a single value per litter.