Table 2.

Electrophysiological properties of male and female Drd1a and Drd2 mouse caudate-putamen medium spiny neurons

PropertyDrd1aDrd2Statistics (F, p)
Resting potential, mVMale: −90.9 ± 1.2 a
Female: −87.5 ± 0.7 a , b
Male: −85.0 ± 1.8 b
Female: −89.0 ± 1.2 a , b
Interaction: F(1,82) = 8.7; p = 0.004
Sex: F(1,82)=0.1; p = 0.75
Subtype: F(1,82)=2.8; p = 0.10
post hoc: Tukey’s
Rheobase, nAMale: 0.16 ± 0.01a
Female: 0.16 ± 0.01a
Male: 0.10 ± 0.02 b
Female: 0.12 ± 0.02 a , b
Interaction: F(1,82) = 0.4; p = 0.52
Sex: F(1,82)=0.4; p = 0.54
Subtype: F(1,82)=12.3; p = 0.0007
post hoc: Tukey’s
AP threshold, mVMale: −58.3 ± 1.0a,b
Female: −54.6 ± 1.2a
Male: −58.6 ± 0.7 a , b
Female: −62.6 ± 2.9 b
Interaction: F(1,81)=7.2; p = 0.0087
Sex: F(1,81)=0.01; p = 0.90
Subtype: F(1,81)=8.0; p = 0.0058
post hoc: Tukey’s
AP amplitude, mVMale: 68.8 ± 2.1
Female: 69.5 ± 2.9
Male: 69.3 ± 2.8
Female: 79.1 ± 3.1
Interaction: F(1,81)=2.3; p = 0.13
Sex: F(1,81)=3.1; p = 0.08
Subtype: F(1,81)=3.0; p = 0.09
AP width at half-peak, msMale: 1.63 ± 0.05a
Female: 1.45 ± 0.05a,b
Male: 1.31 ± 0.06 b
Female: 1.43 ± 0.15a,b
Interaction: F(1,80)=4.7; p = 0.0339
Sex: F(1,80)=0.1; p = 0.7052
Subtype: F(1,80)=5.3; p = 0.0234
post hoc: Tukey’s
AHP peak, mVMale: −8.9 ± 0.4
Female: −11.0 ± 0.7
Male: −9.8 ± 0.8
Female: −9.2 ± 0.7
Interaction: F(1,80)=3.5; p = 0.0654
Sex: F(1,80)=0.8; p = 0.37
Subtype: F(1,80)=0.2; p = 0.69
AHP time to peak, msMale: 32.2 ± 1.3
Female: 26.3 ± 1.6
Male: 31.8 ± 3.4
Female: 32.5 ± 3.2
Interaction: F(1,81)=2.1; p = 0.15
Sex: F(1,81)=1.4; p = 0.24
Subtype: F(1,81)=1.6; p = 0.21
FI slope, Hz/nAMale: 192.5 ± 10.4a
Female: 164.0 ± 12.8a
Male: 278.7 ± 28.9 b
Female: 242.0 ± 23.0 b
Interaction: F(1,81)=0.1; p = 0.82
Sex: F(1,81)=3.4; p = 0.0708
Subtype: F(1,81)=21.2; p < 0.0001
post hoc: Tukey’s
Linear range input resistance, MΩMale: 102.1 ± 5.8a
Female: 93.6 ± 6.6a
Male: 141.0 ± 19.2 b
Female: 109.8 ± 18.3 a , b
Interaction: F(1,78)=1.1; p = 0.30
Sex: F(1,78)=2.9; p = 0.09
Subtype: F(1,78)=6.3; p = 0.0138
post hoc: Tukey’s
Rectified range input resistance, MΩMale: 83.4 ± 4.7
Female: 83.9 ± 8.6
Male: 112.0 ± 17.7
Female: 83.1 ± 11.7
Interaction: F(1,79)=2.0; p = 0.16
Sex: F(1,79)=1.9; p = 0.17
Subtype: F(1,79)=1.8; p = 0.18
Inward rectification, %Male: 82.3 ± 1.3
Female: 81.0 ± 1.8
Male: 80.8 ± 4.3
Female: 79.2 ± 3.3
Interaction: F(1,79)=0.0; p = 0.93
Sex: F(1,79)=0.3; p = 0.57
Subtype: F(1,79)=0.4; p = 0.52
Time constant of the membrane, msMale: 10.3 ± 0.8
Female: 19.6 ± 1.2
Male: 14.6 ± 3.2
Female: 9.9 ± 1.9
Interaction: F(1,82)=2.9; p = 0.09
Sex: F(1,82)=1.2; p = 0.28
Subtype: F(1,82)=1.6; p = 0.20
Capacitance, pFMale: 109.6 ± 10.0
Female: 99.0 ± 7.0
Male: 94.4 ± 11.2
Female: 91.2 ± 8.5
Interaction: F(1,78)=0.1; p = 0.74
Sex: F(1,78)=0.4; p = 0.55
Subtype: F(1,78)=1.0; p = 0.31
mEPSC frequency, HzMale: 1.9 ± 0.2
Female: 1.9 ± 0.2
Male: 2.0 ± 0.5
Female: 1.4 ± 0.4
Interaction: F(1,47)=0.9; p = 0.33
Sex: F(1,47)=1.2; p = 0.29
Subtype: F(1,47)=0.3; p = 0.58
mEPSC amplitude, pAMale: 15.9 ± 0.4a
Female: 15.2 ± 0.6a
Male: 17.7 ± 1.1 a , b
Female: 20.7 ± 1.5 b
Interaction: F(1,47)=5.2; p = 0.0270
Sex: F(1,47)=2.1; p = 0.1498
Subtype: F(1,47)=20.4; p < 0.0001
post hoc: Tukey’s
mEPSC decay, msMale: 1.9 ± 0.2
Female: 1.9 ± 0.2
Male: 2.0 ± 0.5
Female: 1.4 ± 0.4
Interaction: F(1,47)=2.6; p = 0.11
Sex: F(1,47)=0.1; p = 0.76
Subtype: F(1,47)=0.0; p = 0.95
  • Values are mean ± SEM. Bold font indicates statistical significance. Different superscript letters denote significant differences detected by a Tukey’s post hoc test. AP, action potential; AHP, afterhyperpolarization; FI, frequency of evoked spikes to injected depolarization current.