Basic characteristics of P11 mice in individual drug-treated groups used for hyperthermia tests
| Saline | PENT | DZP | BUME | |||||
|---|---|---|---|---|---|---|---|---|
| Conc, mg/kg | — | 0.37 | 37 | 37 | 0.01 | 1 | 1 | 10 |
| BUME, +/− | − | − | − | + | − | − | + | + |
| Body weight at P11, g | 5.4 ± 0.26 | 4.5 ± 0.12 | 5.3 ± 0.16 | 5.3 ± 0.12 | 6.0 ± 0.17 | 5.6 ± 0.15 | 5.0 ± 0.19 | 5.2 ± 0.20 |
| Seizure | 5/5 | 5/5 | 5/5 | 1/5 | 0/4 | 5/5 | 0/5 | 2/4 |
| Death | 0/5 | 0/5 | 0/5 | 1/5 | 0/4 | 5/5 | 5/5 | 1/4 |
| Average temp, °C | 39.6 ± 0.46 | 40.0 ± 0.47 | 39.4 ± 0.57 | 37.7 ± 0.02 | 39.4 ± 0.40 | 38.8 ± 0.73 | 37.7 ± 0.02 | 39.6 ± 0.50 |
| Highest temp, °C | 42.1 ± 0.30 | 42.2 ± 0.16 | 42.1 ± 0.07 | 41.1 ± 0.16 | 41.2 ± 0.16 | 41.3 ± 0.18 | 40.2 ± 0.17 | 41.6 ± 0.14 |
The first three rows represent the types of drugs used (PENT, pentobarbital; DZP, diazepam; BUME, bumetanide), the concentration (Conc) of the drugs, and whether 10 mg/kg bumetanide was coadministered. The bottom rows show the average body weight at P11, the number of animals exhibiting seizures out of the total number of animals tested, the average rectal temperature during hyperthermia induction, and the highest rectal temperature during hyperthermia.