Results from the mixed linear model for quantified membrane potential change using VSDI in MEC of homozygous transgenic animals (+/+) and controls (–/–)
| p values for test of fixed effects | |||||
|---|---|---|---|---|---|
| Genotype | Sex | Distance from electrode | Distance from electrode × genotype | N (slices/animals) | |
| Superficial layers | |||||
| 3 months | 0.095 | 0.116 | 0.000 | 0.652 | 16/6 |
| 9 months | 0.315 | 0.431 | 0.000 | 0.015 | 21/10 |
| 12 months | 0.445 | 0.297 | 0.000 | 0.696 | 13/7 |
| Across layers | |||||
| 3 months | 0.237 | 0.266 | 0.000 | 0.000 | 16/6 |
| 9 months | 0.639 | 0.104 | 0.000 | 0.902 | 21/10 |
| 12 months | 0.673 | 0.750 | 0.000 | 1.000 | 13/7 |
Spread of activity from electrode placed in superficial layers MEC recorded with VSDI for all rats is shown in Extended Data Table 6-1. Values printed in bold face identify significance.