TY - JOUR T1 - Bidirectional Control of Risk-Seeking Behavior by the Basolateral Amygdala JF - eneuro JO - eNeuro DO - 10.1523/ENEURO.0168-18.2018 SP - ENEURO.0168-18.2018 AU - J. Miguel Cisneros-Franco AU - Etienne de Villers-Sidani Y1 - 2018/07/06 UR - http://www.eneuro.org/content/early/2018/07/06/ENEURO.0168-18.2018.abstract N2 - Significance Statement Decision-making under risk entails the possibility of simultaneously receiving positive (reward) and negative (punishment) stimuli. To learn in this context, one must integrate conflicting information related to the magnitude of reward and the probability of punishment. Long-term inactivation of the basolateral amygdala (BLA) disrupts this process and increases risky behavior. In a recent study published in the Journal of Neuroscience, Orisini et al., (2017) showed that briefly inhibiting the basolateral amygdala (BLA) may result in increased or decreased risk-taking behavior, depending on the phase of the decision process in which BLA activity is disrupted. Here we discuss the results and propose future experiments that could improve our understanding of how the BLA contributes to adaptive learning under risk and uncertainty. ER -