RT Journal Article SR Electronic T1 Amygdala Corticofugal Input Shapes Mitral Cell Responses in the Accessory Olfactory Bulb JF eneuro JO eNeuro FD Society for Neuroscience SP ENEURO.0175-18.2018 DO 10.1523/ENEURO.0175-18.2018 VO 5 IS 3 A1 Livio Oboti A1 Eleonora Russo A1 Tuyen Tran A1 Daniel Durstewitz A1 Joshua G. Corbin YR 2018 UL http://www.eneuro.org/content/5/3/ENEURO.0175-18.2018.abstract AB Interconnections between the olfactory bulb and the amygdala are a major pathway for triggering strong behavioral responses to a variety of odorants. However, while this broad mapping has been established, the patterns of amygdala feedback connectivity and the influence on olfactory circuitry remain unknown. Here, using a combination of neuronal tracing approaches, we dissect the connectivity of a cortical amygdala [posteromedial cortical nucleus (PmCo)] feedback circuit innervating the mouse accessory olfactory bulb. Optogenetic activation of PmCo feedback mainly results in feedforward mitral cell (MC) inhibition through direct excitation of GABAergic granule cells. In addition, LED-driven activity of corticofugal afferents increases the gain of MC responses to olfactory nerve stimulation. Thus, through corticofugal pathways, the PmCo likely regulates primary olfactory and social odor processing.