PT  - JOURNAL ARTICLE
AU  - Tobias Egli
AU  - David Coynel
AU  - Klara Spalek
AU  - Matthias Fastenrath
AU  - Virginie Freytag
AU  - Angela Heck
AU  - Eva Loos
AU  - Bianca Auschra
AU  - Andreas Papassotiropoulos
AU  - Dominique J.-F. de Quervain
AU  - Annette Milnik
TI  - Identification of Two Distinct Working Memory-Related Brain Networks in Healthy Young Adults
AID  - 10.1523/ENEURO.0222-17.2018
DP  - 2018 Jan 01
TA  - eneuro
PG  - ENEURO.0222-17.2018
VI  - 5
IP  - 1
4099  - http://www.eneuro.org/content/5/1/ENEURO.0222-17.2018.short
4100  - http://www.eneuro.org/content/5/1/ENEURO.0222-17.2018.full
SO  - eNeuro2018 Jan 01; 5
AB  - Working memory (WM) is an important cognitive domain for everyday life functioning and is often disturbed in neuropsychiatric disorders. Functional magnetic resonance imaging (fMRI) studies in humans show that distributed brain areas typically described as fronto-parietal regions are implicated in WM tasks. Based on data from a large sample of healthy young adults (N = 1369), we applied independent component analysis (ICA) to the WM-fMRI signal and identified two distinct networks that were relevant for differences in individual WM task performance. A parietally-centered network was particularly relevant for individual differences in task measures related to WM performance (“WM dependent”) and a frontally-centered network was relevant for differences in attention-dependent task performance. Importantly, frontal areas that are typically considered as key regions for WM were either involved in both WM-dependent and attention-dependent performance, or in attention-dependent performance only. The networks identified here are provided as publicly available datasets. These networks can be applied in future studies to derive a low-dimensional representation of the overall WM brain activation.