TY - JOUR T1 - Genetic Pathways of Neuroregeneration in a Novel Mild Traumatic Brain Injury Model in Adult Zebrafish JF - eneuro JO - eNeuro DO - 10.1523/ENEURO.0208-17.2017 VL - 5 IS - 1 SP - ENEURO.0208-17.2017 AU - Amanda L. Maheras AU - Brian Dix AU - Olivia M. S. Carmo AU - Aleena E. Young AU - Vanessa N. Gill AU - Julia L. Sun AU - Aleah R. Booker AU - Helen A. Thomason AU - Anastasia E. Ibrahim AU - Lauren Stanislaw AU - Jennifer C. Dallego AU - Cat N. Ngo AU - Audrey Chen AU - Barbara K. Fortini AU - Rory D. Spence Y1 - 2018/01/01 UR - http://www.eneuro.org/content/5/1/ENEURO.0208-17.2017.abstract N2 - Mild traumatic brain injuries (mTBIs) are one of the most prevalent neurological disorders, and humans are severely limited in their ability to repair and regenerate central nervous system (CNS) tissue postinjury. However, zebrafish (Danio rerio) maintain the remarkable ability to undergo complete and functional neuroregeneration as an adult. We wish to extend knowledge of the known mechanisms of neuroregeneration by analyzing the differentially expressed genes (DEGs) in a novel adult zebrafish model of mTBI. In this study, a rodent weight drop model of mTBI was adapted to the adult zebrafish. A memory test showed significant deficits in spatial memory in the mTBI group. We identified DEGs at 3 and 21 days postinjury (dpi) through RNA-sequencing analysis. The resulting DEGs were categorized according to gene ontology (GO) categories. At 3 dpi, GO categories consisted of peak injury response pathways. Significantly, at 21 dpi, GO categories consisted of neuroregeneration pathways. Ultimately, these results validate a novel zebrafish model of mTBI and elucidate significant DEGs of interest in CNS injury and neuroregeneration. ER -