PT - JOURNAL ARTICLE AU - Zachary Yaple AU - Mario Martinez-Saito AU - Bhuvanesh Awasthi AU - Matteo Feurra AU - Anna Shestakova AU - Vasily Klucharev TI - Transcranial Alternating Current Stimulation Modulates Risky Decision Making in a Frequency-Controlled Experiment AID - 10.1523/ENEURO.0136-17.2017 DP - 2017 Nov 01 TA - eneuro PG - ENEURO.0136-17.2017 VI - 4 IP - 6 4099 - http://www.eneuro.org/content/4/6/ENEURO.0136-17.2017.short 4100 - http://www.eneuro.org/content/4/6/ENEURO.0136-17.2017.full SO - eNeuro2017 Nov 01; 4 AB - In this study, we investigated the effect of transcranial alternating current stimulation (tACS) on voluntary risky decision making and executive control in humans. Stimulation was delivered online at 5 Hz (θ), 10 Hz (α), 20 Hz (β), and 40 Hz (γ) on the left and right frontal area while participants performed a modified risky decision-making task. This task allowed participants to voluntarily select between risky and certain decisions associated with potential gains or losses, while simultaneously measuring the cognitive control component (voluntary switching) of decision making. The purpose of this experimental design was to test whether voluntary risky decision making and executive control can be modulated with tACS in a frequency-specific manner. Our results revealed a robust effect of a 20-Hz stimulation over the left prefrontal area that significantly increased voluntary risky decision making, which may suggest a possible link between risky decision making and reward processing, underlined by β-oscillatory activity.