PT  - JOURNAL ARTICLE
AU  - Gokhan Guner
AU  - Gizem Guzelsoy
AU  - Fatma Sadife Isleyen
AU  - Gulcan Semra Sahin
AU  - Cansu Akkaya
AU  - Efil Bayam
AU  - Eser Ilgin Kotan
AU  - Alkan Kabakcioglu
AU  - Gulayse Ince-Dunn
TI  - NEUROD2 Regulates <em>Stim1</em> Expression and Store-Operated Calcium Entry in Cortical Neurons
AID  - 10.1523/ENEURO.0255-16.2017
DP  - 2017 Jan 01
TA  - eneuro
PG  - ENEURO.0255-16.2017
VI  - 4
IP  - 1
4099  - http://www.eneuro.org/content/4/1/ENEURO.0255-16.2017.short
4100  - http://www.eneuro.org/content/4/1/ENEURO.0255-16.2017.full
SO  - eNeuro2017 Jan 01; 4
AB  - Calcium signaling controls many key processes in neurons, including gene expression, axon guidance, and synaptic plasticity. In contrast to calcium influx through voltage- or neurotransmitter-gated channels, regulatory pathways that control store-operated calcium entry (SOCE) in neurons are poorly understood. Here, we report a transcriptional control of Stim1 (stromal interaction molecule 1) gene, which is a major sensor of endoplasmic reticulum (ER) calcium levels and a regulator of SOCE. By using a genome-wide chromatin immunoprecipitation and sequencing approach in mice, we find that NEUROD2, a neurogenic transcription factor, binds to an intronic element within the Stim1 gene. We show that NEUROD2 limits Stim1 expression in cortical neurons and consequently fine-tunes the SOCE response upon depletion of ER calcium. Our findings reveal a novel mechanism that regulates neuronal calcium homeostasis during cortical development.