TY - JOUR T1 - In Vivo Reprogramming for Brain and Spinal Cord Repair JF - eneuro JO - eneuro DO - 10.1523/ENEURO.0106-15.2015 SP - ENEURO.0106-15.2015 AU - Gong Chen AU - Marius Wernig AU - Benedikt Berninger AU - Masato Nakafuku AU - Malin Parmar AU - Chun-Li Zhang Y1 - 2015/10/08 UR - http://www.eneuro.org/content/early/2015/10/08/ENEURO.0106-15.2015.abstract N2 - Cell reprogramming technologies have enabled the generation of various specific cell types including neurons from readily accessible patient cells such as skin fibroblasts providing an intriguing novel cell source for autologous cell transplantation. However, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival and functional integration after transplantation. Recently, in vivo reprogramming, which makes use of endogenous cells for regeneration purpose, emerged as a new approach to circumvent cell transplantation. There has been evidence for in vivo reprogramming in the mouse pancreas, heart, and brain and spinal cord with various degrees of success. This minireview summarizes the latest developments presented in the first symposium on in vivo reprogramming glial cells into functional neurons in the brain and spinal cord, held at the 2014 annual meeting of Society for Neuroscience in Washington DC.Significance Statement: We have had the first symposium on in vivo reprogramming at the 2014 SFN meeting held at Washington DC. Our symposium attracted more than 800 people from around the world. This symposium invited world leaders in this emerging new field to present their most exciting results on in vivo reprogramming glial cells into functional neurons. This minireview discussed the latest developments on in vivo reprogramming and its potential application for brain and spinal cord repair. ER -