PT  - JOURNAL ARTICLE
AU  - Susanne Becker
AU  - Wiebke Gandhi
AU  - Saskia Kwan
AU  - Alysha-Karima Ahmed
AU  - Petra Schweinhardt
TI  - Doubling Your Payoff: Winning Pain Relief Engages Endogenous Pain Inhibition
AID  - 10.1523/ENEURO.0029-15.2015
DP  - 2015 Jul 01
TA  - eneuro
PG  - ENEURO.0029-15.2015
VI  - 2
IP  - 4
4099  - http://www.eneuro.org/content/2/4/ENEURO.0029-15.2015.short
4100  - http://www.eneuro.org/content/2/4/ENEURO.0029-15.2015.full
SO  - eneuro2015 Jul 01; 2
AB  - When in pain, pain relief is much sought after, particularly for individuals with chronic pain. In analogy to augmentation of the hedonic experience (“liking”) of a reward by the motivation to obtain a reward (“wanting”), the seeking of pain relief in a motivated state might increase the experience of pain relief when obtained. We tested this hypothesis in a psychophysical experiment in healthy human subjects, by assessing potential pain-inhibitory effects of pain relief “won” in a wheel of fortune game compared with pain relief without winning, exploiting the fact that the mere chance of winning induces a motivated state. The results show pain-inhibitory effects of pain relief obtained by winning in behaviorally assessed pain perception and ratings of pain intensity. Further, the higher participants scored on the personality trait novelty seeking, the more pain inhibition was induced. These results provide evidence that pain relief, when obtained in a motivated state, engages endogenous pain-inhibitory systems beyond the pain reduction that underlies the relief in the first place. Consequently, such pain relief might be used to improve behavioral pain therapy, inducing a positive, perhaps self-amplifying feedback loop of reduced pain and improved functionality.