RT Journal Article SR Electronic T1 Conditional Inhibition of Adult Neurogenesis by Inducible and Targeted Deletion of ERK5 MAP Kinase Is Not Associated with Anxiety/Depression-Like Behaviors JF eneuro JO eneuro FD Society for Neuroscience SP ENEURO.0014-14.2015 DO 10.1523/ENEURO.0014-14.2015 VO 2 IS 2 A1 Junhui Zou A1 Wenbin Wang A1 Yung-Wei Pan A1 Glen M. Abel A1 Daniel R. Storm A1 Zhengui Xia YR 2015 UL http://www.eneuro.org/content/2/2/ENEURO.0014-14.2015.abstract AB Although there is evidence that adult neurogenesis contributes to the therapeutic efficacy of chronic antidepressant treatment for anxiety and depression disorders, the role of adult neurogenesis in the onset of depression-related symptoms is still open to question. To address this issue, we utilized a transgenic mouse strain in which adult neurogenesis was specifically and conditionally impaired by Nestin-CreER-driven, inducible knockout (icKO) of erk5 MAP kinase in Nestin-expressing neural progenitors of the adult mouse brain upon tamoxifen administration. Here, we report that inhibition of adult neurogenesis by this mechanism is not associated with an increase of the baseline anxiety or depression in non-stressed animals, nor does it increase the animal’s susceptibility to depression after chronic unpredictable stress treatment. Our findings indicate that impaired adult neurogenesis does not lead to anxiety or depression.