TY - JOUR T1 - Characteristics of Waveform Shape in Parkinson’s Disease Detected with Scalp Electroencephalography JF - eneuro JO - eNeuro DO - 10.1523/ENEURO.0151-19.2019 VL - 6 IS - 3 SP - ENEURO.0151-19.2019 AU - Nicko Jackson AU - Scott R. Cole AU - Bradley Voytek AU - Nicole C. Swann Y1 - 2019/05/01 UR - http://www.eneuro.org/content/6/3/ENEURO.0151-19.2019.abstract N2 - Neural activity in the β frequency range (13–30 Hz) is excessively synchronized in Parkinson’s disease (PD). Previous work using invasive intracranial recordings and non-invasive scalp electroencephalography (EEG) has shown that correlations between β phase and broad-band γ (>50 Hz) amplitude [i.e., phase amplitude coupling (PAC)] are elevated in PD, perhaps a reflection of this synchrony. Recently, it has also been shown, in invasive human recordings, that non-sinusoidal features of β oscillation shape also characterize PD. Here, we show that these features of β waveform shape also distinguish PD patients on and off medication using non-invasive recordings in a dataset of 15 PD patients with resting scalp EEG. Specifically, β oscillations over sensorimotor electrodes in PD patients off medication had greater sharpness asymmetry and steepness asymmetry than on medication (sign rank, p < 0.02, corrected). We also showed that β oscillations over sensorimotor cortex most often had a canonical shape, and that using this prototypical shape as an inclusion criteria increased the effect size of our findings. Together, our findings suggest that novel ways of measuring β synchrony that incorporate waveform shape could improve detection of PD pathophysiology in non-invasive recordings. Moreover, they motivate the consideration of waveform shape in future EEG studies. ER -