PT  - JOURNAL ARTICLE
AU  - Anabelle Planques
AU  - Vanessa Oliveira Moreira
AU  - Chantal Dubreuil
AU  - Alain Prochiantz
AU  - Ariel A. Di Nardo
TI  - OTX2 Signals from the Choroid Plexus to Regulate Adult Neurogenesis
AID  - 10.1523/ENEURO.0262-18.2019
DP  - 2019 Mar 01
TA  - eneuro
PG  - ENEURO.0262-18.2019
VI  - 6
IP  - 2
4099  - http://www.eneuro.org/content/6/2/ENEURO.0262-18.2019.short
4100  - http://www.eneuro.org/content/6/2/ENEURO.0262-18.2019.full
SO  - eNeuro2019 Mar 01; 6
AB  - Proliferation and migration during adult neurogenesis are regulated by a microenvironment of signaling molecules originating from local vasculature, from CSF produced by the choroid plexus, and from local supporting cells including astrocytes. Here, we focus on the function of OTX2 homeoprotein transcription factor in the mouse adult ventricular-subventricular zone (V-SVZ), which generates olfactory bulb neurons. We find that OTX2 secreted by choroid plexus is transferred to the supporting cells of the V-SVZ and rostral migratory stream. Deletion of Otx2 in choroid plexus affects neuroblast migration and reduces the number of olfactory bulb newborn neurons. Adult neurogenesis was also decreased by expressing secreted single-chain antibodies to sequester OTX2 in the CSF, demonstrating the importance of non-cell-autonomous OTX2. We show that OTX2 activity modifies extracellular matrix components and signaling molecules produced by supporting astrocytes. Thus, we reveal a multilevel and non-cell-autonomous role of a homeoprotein and reinforce the choroid plexus and astrocytes as key niche compartments affecting adult neurogenesis.