Drd4 | ADHD | ↓ corticostriatal glutamate release |
Bonaventura et al. (2017) |
Shank3b | ASDOCD | ↑ dendritic arborizations↓ synaptogenesis/spinogenesis↑ precocious hyperactivity of corticostriatal inputs during development↓ corticostriatal synaptic transmission in adulthood |
Peça et al. (2011)
Peixoto et al. (2016)
|
Fmr1 | ASD | ↑ inhibitory neurotransmission in the striatum↓ corticostriatal plasticity (LTD)↓ corticostriatal connectivity |
Centonze et al. (2008)
Jung et al. (2012)
Zerbi et al. (2018)
|
Foxp1 | ASD | ↑ excitability of iSPNs |
Araujo et al. (2015) |
elf4e | ASD | ↑ spinogenesis in Layer II/III of medial prefrontal cortex↑ corticostriatal plasticity (LTD) |
Santini et al. (2013) |
Nlgn1 | ASD | ↓ NMDA-mediated synaptic transmission of dSPNs↓ mEPSCs in iSPNs |
Blundell et al. (2010)
Espinosa et al. (2015)
|
Nlgn3 | ASD | ↓ inhibitory synaptic transmission in dSPNs of the ventral striatum↓ corticostriatal plasticity (LTD) |
Rothwell et al. (2014)
Martella et al. (2018)
|
Tshz3 | ASD | ↑ corticostriatal LTP |
Caubit et al. (2016) |
Met | ASDSLD | ↑ neuronal activity of corticostriatal pyramidal neurons in Layer Vb |
Qiu et al. (2011) |
Mef2c | ASDSLD | ↑ synaptogenesis/spinogenesis in the striatum↑ mEPSCs in SPNs |
Chen et al. (2016) |
Cntnap2 | ASDSLD | ↓ number of striatal GABAergic interneurons |
Peñagarikano et al. (2011) |
Slitrk5 | OCD | ↓ BDNF-mediated neurite outgrowth of striatal neurons↑ neuronal activity of the orbitofrontal cortex↓ corticostriatal transmission↓ dendritic complexity of SPNs↓ GluR2, NR2B in the striatum |
Song et al. (2015)
Shmelkov et al. (2010)
|
Sapap3 | OCD | ↓ postsynaptic density thickness↑ NR1, NR2B and↑NR2A in the striatal PSD fraction↓ corticostriatal field EPSP↓ corticostriatal quantal EPSP in the iSPNs↓ corticostriatal feedforward inhibition of fast-spiking interneurons |
Welch et al. (2007)
Wan et al. (2014)
Burguière et al. (2013)
|
Slc1a1 | OCD | ↓ neuronal activity in response to amphetamine in the dorsal striatum↓ NR2A and corticostriatal LTD in the dorsal striatum |
Zike et al. (2017)
Delgado-Acevedo et al. (2019)
|
ErbB4 | Schizophrenia | ↑ inhibitory synaptic transmission in the striatum↑ GABAAα1 in the striatum |
Geng et al. (2017) |
Zswim6 | Schizophrenia | ↓ neurite arborizations in the striatum↓ spinogenesis in the striatum |
Tischfield et al. (2017) |
Foxp2 | SLD | ↓ corticostriatal synaptic transmission↓ corticostriatal plasticity (LTD)↓ synaptogenesis/spinogenesis in the striatum↓ mEPSCs in SPNs |
Groszer et al. (2008)
Enard et al. (2009)
Reimers-Kipping et al. (2011)
Chen et al. (2016)
|