1 | Log2-transformed to normalize data | One-way ANOVA (Tukey’s post hoc test) | CFA: 5 Onset: 5 Chronic: 5 | A: F(2,12) = 17.78, p = 0.0003 B: F(2,12) = 4.217, p = 0.0410 C: F(2,12) = 8.126, p = 0.0059 Di: F(2,12) = 34.37, p < 0.0001 Dii: F(2,12) = 42.74, p < 0.0001 Diii: F(2,12) = 42.83, p < 0.0001 Div: F(2,12) = 9.410, p = 0.0035 |
2A | Normal | One-way ANOVA (Tukey’s post hoc test) | CFA: 4 Onset: 5 Chronic: 5 | F(2,11) = 17.51, p = 0.0004 |
2B | Normal | One-way ANOVA (Tukey’s post hoc test) | CFA: 5 Onset: 5 Chronic: 3 | F(2,10) = 6.254, p = 0.0173 |
2C | Normal | One-way ANOVA (Tukey’s post hoc test) | CFA: 4 Onset: 5 Chronic: 4 | F(2,10) = 6.361, p = 0.0165 |
3A–C | Log2-transformed to normalize data | One-way ANOVA (Tukey’s post hoc test) | CFA: 4 Onset: 3 Chronic: 3 | A: F(2,7) = 0.9470, p = 0.4325 B: F(2,7) = 2.747, p = 0.1317 C: F(2,7) = 0.9616, p = 0.4276 |
3D–I | Log2-transformed to normalize data | One-way ANOVA (Tukey’s post hoc test) | CFA: 5 Onset: 5 Chronic: 5 | D: F(2,12) = 0.7474, p = 0.4944 E: F(2,12) = 1.770, p = 0.2120 F: F(2,12) = 0.8078, p = 0.4687 G: F(2,12) = 10.52, p = 0.0023 H: F(2,12) = 9.242, p = 0.0037 I: F(2,12) = 12.56, p = 0.0011 |
4C | Non-normal | Two-tailed unpaired t test with Welch’s correction | CFA: 5 EAE: 13 | t(12.41) = 3.237, p = 0.0069 |
5A–E | Log2-transformed to normalize data | One-way ANOVA (Tukey’s post hoc test) | CFA: 5 Onset: 4 Chronic: 4 | A: F(2,10) = 10.73, p = 0.0032 B: F(2,10) = 29.40, p < 0.0001 C: F(2,10) = 4.361, p = 0.0435 D: F(2,10) = 25.80, p = 0.0001 E: F(2,10) = 15.92, p = 0.0011 |
5H | Normal | One-way ANOVA (Tukey’s post hoc test) | CFA: 4 Onset: 6 Chronic: 6 | F(2,13) = 7.750, p = 0.0061 |
6C | Non-parametric | Kruskal–Wallis H test | <26 µm: CFA: 33 Onset: 17 Chronic: 27 ≥26 µm: CFA: 76 Onset: 51 Chronic: 94 | <26 µm: H0.5nA(2) = 0.3138, p = 0.8548 H1.0nA(2) = 0.1677, p = 0.9196 H1.5nA(2) = 0.8715, p = 0.2750 H2.0nA(2) = 0.9634, p = 0.6177 ≥26 µm: H0.5nA(2) = 1.498, p = 0.4728 H1.0nA(2) = 3.924, p = 0.1406 H1.5nA(2) = 7.448, p = 0.0241 H2.0nA(2) = 9.943, p = 0.0069 |
6D | Normal | One-way ANOVA (Tukey’s post hoc test) | <26 µm: CFA: 24 Onset: 13 Chronic: 27 ≥26 µm: CFA: 76 Onset: 51 Chronic: 94 | F<26µm(2,61) = 1.849, p = 0.1660 F≥26µm(2,219) = 5.274, p = 0.0058 |
6G | Normal | One-way ANOVA (Tukey’s post hoc test) | CFA: 24 Onset: 13 Chronic: 27 | F(2,61) = 1.238, p = 0.2971 |
6H | Normal | Two-way ANOVA (Tukey’s post hoc test) | CFA: 31 Onset: 17 Chronic: 25 | Disease: F(2,444) = 2.740, p = 0.0657 Spike number: F(7,444) = 25.00, p < 0.0001 Interaction: F(14,444) = 0.1811, p = 0.9996 |
6J | Normal | One-way ANOVA (Tukey’s post hoc test) | CFA: 76 Onset: 52 Chronic: 94 | F(2,219) = 1.832, p = 0.1625 |
6K | Normal | Two-way ANOVA (Tukey’s post hoc test) | CFA: 40 Onset: 27 Chronic: 44 | Disease: F(2,708) = 38.03, p < 0.0001 Spike number: F(7,708) = 11.82, p < 0.0001 Interaction: F(14,708) = 0.6171, p = 0.8522 |
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Table 3 | Normal and non-normal | One-way ANOVA (Tukey’s post hoc test) or Kruskal–Wallis H test | <26 µm: CFA: 24 Onset: 13 Chronic: 27 ≥26 µm: CFA: 76 Onset: 51 Chronic: 94 | Peak amplitude: F<26µm(2,61) = 0.6022, p = 0.5508 F≥26µm(2,219) = 3.883, p = 0.0220 Afterhyperpolarization amplitude: F<26µm(2,61) = 5.211, p = 0.0081 F≥26µm(2,219) = 2.481, p = 0.0860 Half width (as plotted in Fig. 6): F<26µm(2,61) = 1.238, p = 0.2971 F≥26µm(2,219) = 1.832, p = 0.1625 Rise slope: H<26µm(2) = 14.44, p = 0.0007 H≥26µm(2) = 50.99, p < 0.0001 Decay slope: F<26µm(2,61) = 1.423, p = 0.2488 F≥26µm(2,219) = 10.08, p < 0.0001 Rheobase (as plotted in Fig. 6): F<26µm(2,61) = 1.849, p = 0.1660 F≥26µm(2,219) = 5.274, p = 0.0058 |