2*A* | rTgFKBP5 (*N* = 10), WT (*N* = 10) | M and F | 4–6 months old | Student’s *t* test (unpaired, two-tailed) | Genotype | *F* = 25, DFn = 9 | *p* < 0.0001 |

3*A* | rTgFKBP5 (1M *N* = 16; 3M *N* = 26, 4M *N* = 21; 6M *N* = 7); WT (1M *N* = 19; 3M *N* = 33, 4M *N* = 26; 6M *N* = 6) tTA (1M *N* = 9; 3M *N* = 15, 4M *N* = 22; 6M *N* = 9) | M and F | Varies | Two-way repeated-measures ANOVA with Bonferroni *post hoc* test | Genotype × age | *F* = 0.63; DFn = 6 | *p* = 0.705 |

Genotype | *F* = 5.44; DFn = 2 | *p* = 0.005 |

Age | *F* = 48.97; DFn = 3 | *p* < 0.0001 |

3*B* | rTgFKBP5 (*N* = 16), WT (*N* = 22), tTA (*N* = 20) | M and F | 3 months old | One-way ANOVA with Tukey *post hoc* test | Genotype | *F* = 0.8867 | *p* = 0.4178 |

3*C* | rTgFKBP5 (*N* = 16), WT (*N* = 22), tTA (*N* = 19) | M and F | 3 months old | One-way ANOVA with Tukey *post hoc* test | Genotype | *F* = 3.749 | *p* = 0.0299 |

3*D* | rTgFKBP5 (*N* = 16), WT (*N* = 22), tTA (*N* = 19) | M and F | 3 months old | One-way ANOVA with Tukey *post hoc* test | Genotype | *F* = 10.04 | *p* = 0.0002 |

3*E* | rTgFKBP5 (*N* = 16), WT (*N* = 22), tTA (*N* = 20) | M and F | 3 months old | One-way ANOVA with Tukey *post hoc* test | Genotype | *F* = 5.099 | *p* = 0.0093 |

3*F* | rTgFKBP5 (*N* = 16), WT (*N* = 22), tTA (*N* = 20) | M and F | 3 months old | One-way ANOVA with Tukey *post hoc* test | Genotype | *F* = 0.3405 | *p* = 0.7129 |

3*G* | rTgFKBP5 (*N* = 16), WT (*N* = 22), tTA (*N* = 20) | M and F | 3 months old | One-way ANOVA with Tukey *post hoc* test | Genotype | *F* = 4.094 | *p* = 0.0219 |

4*A* | rTgFKBP5 (*N* = 10), WT (*N* = 10), tTA (*N* = 10) | M and F | 4–6 months old | Two-way repeated-measures ANOVA with Bonferroni *post hoc* test | Genotype × training day | *F* = 0.26; DFn = 6 | *p* = 0.9525 |

Genotype | *F* = 7.39; DFn = 2 | *p* = 0.0010 |

Training day | *F* = 21.56; DFn = 3 | *p* < 0.0001 |

4*B* | rTgFKBP5 (*N* = 10), WT (*N* = 10), tTA (*N* = 10) | M and F | 4–6 months old | One-way ANOVA with Tukey *post hoc* test | Quadrant time | rTgFKBP5: *F* = 9.948; WT: *F* = 31.30; tTA: *F* = 15.97 | rTgFKBP5: *p* < 0.0001; WT: *p* < 0.0001; tTA: *p* < 0.0001; |

4*C* | rTgFKBP5 (*N* = 10), WT (*N* = 10), tTA (*N* = 10) | M and F | 4–6 months old | Two-way repeated-measures ANOVA with Bonferroni *post hoc* test | Genotype × training day | *F* = 0.82; DFn = 4 | *p* = 0.5146 |

Genotype | *F* = 9.49; DFn = 2 | *p* = 0.0002 |

Training day | *F* = 12.66; DFn = 2 | *p* < 0.0001 |

4*D* | rTgFKBP5 (*N* = 10), WT (*N* = 10), tTA (*N* = 10) | M and F | 4–6 months old | One-way ANOVA with Tukey *post hoc* test | Quadrant time | rTgFKBP5: *F* = 2.038; WT: *F* = 15.22; tTA: *F* = 31.26 | rTgFKBP5: *p* = 0.1259; WT: *p* < 0.0001; tTA: *p* < 0.0001 |

5*A* | rTgFKBP5 (*N* = 5; *n* = 18), WT (*N* = 6; *n* = 29), tTA (*N* = 5; *n* = 22) | M and F | 2–3.5 months old | Two-way repeated-measures ANOVA with Bonferroni *post hoc* test | Genotype × time | *F* = 4.820; DFn = 158 | *p* < 0.0001 |

Genotype | *F* = 1036 DFn = 2 | *p* < 0.0001 |

Time | *F* = 103.1; DFn = 79 | *p* < 0.0001 |

One-way ANOVA with Tukey *post hoc* test | Genotype | *F* = 872.5 | *p* < 0.0001 |

5*B* | rTgFKBP5 (*N* = 7; *n* = 16), WT (*N* = 6; *n* = 23), and tTA (*N* = 8; *n* = 26) | M and F | 2–3.5 months old | Two-way repeated-measures ANOVA with Bonferroni *post hoc* test | Genotype × time | *F* = 2.484; DFn= 164 | *p* < 0.0001 |

Genotype | *F* = 344.9; DFn = 2 | *p* < 0.0001 |

Time | *F* = 117.6; DFn = 82 | *p* < 0.0001 |

One-way ANOVA with Tukey *post hoc* test of last 5 min of LTP | Genotype | *F* = 154.1 | *p* < 0.0001 |

6*A* | rTgFKBP5 (*N* = 15; *n* = 65), WT (*N* = 15; *n* = 62), and tTA (*N* = 19; *n* = 77) | M and F | 2–3.5 months old | Two-way repeated-measures ANOVA with Bonferroni *post hoc* test | Genotype × time | *F* = 2.562; DFn = 58 | *p* < 0.0001 |

Genotype | *F* = 158.60; DFn = 2 | *p* < 0.0001 |

Time | *F* = 515.25; DFn = 29 | *p* < 0.0001 |

6*B* | rTgFKBP5 (*N* = 15; *n* = 65), WT (*N* = 15; *n* = 62), and tTA (*N* = 19; *n* = 77) | M and F | 2–3.5 months old | Two-way repeated-measures ANOVA with Bonferroni *post hoc* test | Genotype × time | *F* = 1.763; DFn = 58 | *p* = 0.0004 |

Genotype | *F* = 117.2; DFn = 2 | *p* < 0.0001 |

Time | *F* = 239.1; DFn = 29 | *p* < 0.0001 |

6*D* | rTgFKBP5 (*N* = 31; *n* = 175), WT (*N* = 33; *n* = 198), and tTA (*N* = 30; *n* = 181) | M and F | 2–3.5 months old | Two-way repeated-measures ANOVA with Bonferroni *post hoc* test | Genotype × time | *F* = 0.7413; DFn = 28 | *p* = 0.8337 |

Genotype | *F* = 44.78; DFn = 2 | *p* < 0.0001 |

Time | *F* = 50.97; DFn = 14 | *p* < 0.0001 |

7 | rTgFKBP5 (*N* = 9; *n* = 21), WT (*N* = 9; *n* = 23), and tTA (*N* = 10; *n* = 31) | M and F | 2–3.5 months old | Two-way repeated-measures ANOVA with Bonferroni *post hoc* test | Genotype × time | *F* = 2.557 DFn = 158 | *p* < 0.0001 |

Genotype | *F* = 561.9; DFn = 2 | *p* < 0.0001 |

Time | *F* = 33.52; DFn = 79 | *p* < 0.0001 |

One-way ANOVA with Tukey *post hoc* test of last 5 min of LTD | Genotype | *F* = 2065 | *p* < 0.0001 |

8*B* | rTgFKBP5 (*N* = 4; *n* = 8), WT (*N* = 2; *n* = 4) and tTA (*N* = 2; *n* = 4) | M and F | 2–3 months old | Mann–Whitney test exact significance (two-tailed) | Between genotypes at 2 min | *p* = 0.3429 |

Between genotypes at 5 min | *p* = 0.0286 |

Between genotypes at 10 min | *p* = 0.0286 |

Between genotypes at 30 min | *p* = 0.1143 |