Article Information
- Received November 28, 2018
- Revision received December 6, 2018
- Accepted December 10, 2018
- Published online December 19, 2018.
Author Information
- Kent Z. Q. Wang1,†,
- Erin Steer1,†,
- P. Anthony Otero1,†,
- Nicholas W. Bateman2,
- Mary Hongying Cheng3,
- Ana Ligia Scott3,
- Christine Wu2,
- Ivet Bahar3,
- Yu-Tzu Shih4,
- Yi-Ping Hsueh4 and
- Charleen T. Chu1,5
- 1Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213
- 2Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213
- 3Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213
- 4Academia Sinica, Institute of Molecular Biology, Taipei, Taiwan 11529
- 5Pittsburgh Institute for Neurodegenerative Diseases, McGowan Institute for Regenerative Medicine, Center for Protein Conformational Diseases and Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA 15213
- Correspondence should be addressed to Dr. Charleen T. Chu, Department of Pathology, University of Pittsburgh School of Medicine, 200 Lothrop Street, S701 Scaife Hall, Pittsburgh, PA 15213, E-mail: ctc4{at}pitt.edu.
Author contributions
Author contributions: K.Z.Q.W., E.S., P.A.O., I.B., Y.-P.H., and C.T.C. designed research; K.Z.Q.W., E.S., P.A.O., N.W.B., M.H.C., and A.L.S. performed research; C.W., Y.-T.S., and Y.-P.H. contributed unpublished reagents/analytic tools; K.Z.Q.W., E.S., P.A.O., N.W.B., M.H.C., A.L.S., I.B., and C.T.C. analyzed data; K.Z.Q.W., E.S., P.A.O., and C.T.C. wrote the paper.
↵† K.Z.Q.W, E.S., and P.A.O. contributed equally to this work.
Disclosures
The authors declare no competing financial interests.
This work was supported in part by the National Institutes of Health (NIH) Grants NS101628 (co-funded by NINDS/NIA), AG026389, and NS065789 (to C.T.C.) and P41 GM103712 and P30 DA035778 (to I.B.); by the Ministry of Science and Technology, Taiwan Grant MOST 107-2321-B-001-011 (to Y.-P.H.); and by a gift from the Helen Mendel Fund. The Fusion Orbitrap instrumentation is supported by NIH Grant S10 OD018056.
E. Steer’s present address: LGC Genomics - Douglas Scientific, Alexandria, MN 56308.
N. W. Bateman’s present address: Gynecologic Cancer Center of Excellence, John P. Murtha Cancer Center, Walter Reed National Military Medical Center, Bethesda, MD 20889.
C. Wu’s present address: Stratus Biosciences, Seattle, WA 98117.
Y.-T. Shih’s present address: Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Funding
HHS | National Institutes of Health (NIH)
R01 NS101628; R01 AG026389; R01 NS065789; P41 GM103712; P30 DA035788; S10 OD018056Ministry of Science and Technology, Taiwan (MOST)
MOST 107-2321-B-001-011
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