Fig. 1B | PV cell density | Unpaired t test | WT vs. Mecp2 KO | P56 | t(10) = 2.82, p = 0.018 |
Fig. 1C | PV fluorescence intensity | Unpaired t test | WT vs. Mecp2 KO | P56 | t(10) = 3.24, p = 0.009 |
Fig. 1D | Relative frequency of PV INs | Mann–Whitney U test | WT vs. Mecp2 KO | P56 | p < 0.001 |
Fig. 1E | Fraction of PV INs | Unpaired t test | WT vs. Mecp2 KO (high PV) | P56 | t(10) = 3.31, p = 0.008 |
| | | WT vs. Mecp2 KO (medium-high PV) | P56 | t(10) = 1.91, p = 0.085 |
| | | WT vs. Mecp2 KO (medium-low PV) | P56 | t(10) = 1.93, p = 0.083 |
| | | WT vs. Mecp2 KO (low PV) | P56 | t(10) = 1.81, p = 0.101 |
Fig. 1G | PV cell density | Unpaired t test | WT vs. Mecp2 KO | P28 | t(10) = 0.61, p = 0.555 |
Fig. 1H | PV fluorescence intensity | Unpaired t test | WT vs. Mecp2 KO | P28 | t(10) = 3.24, p = 0.268 |
Fig. 1I | Relative frequency of PV INs | Mann–Whitney U test | WT vs. Mecp2 KO | P28 | p = 0.002 |
Fig. 1J | Fraction of PV INs | Unpaired t test | WT vs. Mecp2 KO (high PV) | P28 | t(10) = 0.32, p = 0.756 |
| | | WT vs. Mecp2 KO (medium-high PV) | P28 | t(10) = 1.92, p = 0.083 |
| | | WT vs. Mecp2 KO (medium-low PV) | P28 | t(10) = 1.29, p = 0.228 |
| | | WT vs. Mecp2 KO (low PV) | P28 | t(10) = 1.54, p = 0.155 |
Fig. 2E | VGLUT1 density on PV dendrites | Unpaired t test | WT vs. Mecp2 KO | P56 | t(10) = 3.62, p = 0.004 |
Fig. 2F | VGAT density on PV dendrites | Unpaired t test | WT vs. Mecp2 KO | P56 | t(7) = 4.22, p = 0.003 |
Fig. 2G | VGLUT1 density on PV soma | Unpaired t test | WT vs. Mecp2 KO | P56 | t(10) = 4.05, p = 0.002 |
Fig. 2H | VGAT density on PV soma | Unpaired t test | WT vs. Mecp2 KO | P56 | t(8) = 1.97, p = 0.08 |
Fig. 2M | VGLUT1 density on CR dendrites | Unpaired t test | WT vs. Mecp2 KO | P56 | t(10) = 2.50, p = 0.03 |
Fig. 2N | VGAT density on CR dendrites | Unpaired t test | WT vs. Mecp2 KO | P56 | t(8) = 0.19, p = 0.85 |
Fig. 2O | VGLUT1 density on CR soma | Unpaired t test | WT vs. Mecp2 KO | P56 | t(10) = 1.32, p = 0.21 |
Fig. 2P | VGAT density on CR soma | Unpaired t test | WT vs. Mecp2 KO | P56 | t(8)= 1.79, p = 0.11 |
Fig. 3E | VGLUT1 density on PV dendrites | Unpaired t test | WT vs. Mecp2 KO | P28 | t(8) = 4.89, p = 0.001 |
Fig. 3F | VGAT density on PV dendrites | Unpaired t test | WT vs. Mecp2 KO | P28 | t(8) = 3.39, p = 0.009 |
Fig. 3G | VGLUT1 density on PV soma | Unpaired t test | WT vs. Mecp2 KO | P28 | t(14) = 0.91, p = 0.38 |
Fig. 3H | VGAT density on PV soma | Unpaired t test | WT vs. Mecp2 KO | P28 | t(8) = 0.24, p = 0.81 |
Fig. 3M | VGLUT1 density on CR dendrites | Unpaired t test | WT vs. Mecp2 KO | P28 | t(8) = 0.24, p = 0.82 |
Fig. 3N | VGAT density on CR dendrites | Unpaired t test | WT vs. Mecp2 KO | P28 | t(8) = 0.29, p = 0.78 |
Fig. 3O | VGLUT1 density on CR soma | Unpaired t test | WT vs. Mecp2 KO | P28 | t(9) = 0.14, p = 0.89 |
Fig. 3P | VGAT density on CR soma | Unpaired t test | WT vs. Mecp2 KO | P28 | t(8) = 0.02, p = 0.99 |
Fig. 4C | VSD response (ΔF/F) | Two-way ANOVA | WT vs. Mecp2 KO | P45-60 | Genotype F(1,136) = 37.07, p < 0.001 |
Fig. 4D | Spatial spread of VSD signal | Two-way ANOVA | WT vs. Mecp2 KO | P45-60 | Genotype F(1,136) = 18.26, p < 0.001 |
Fig. 4E | Spatial spread of VSD signal | Unpaired t test | WT vs. Mecp2 KO | P45-60 | p < 0.05 |
Fig. 4G | VSD response (ΔF/F) | Two-way ANOVA | WT vs. Mecp2 KO | P24-26 | Genotype F(1,96) = 2.73, p = 0.108 |
Fig. 4H | Spatial spread of VSD signal | Two-way ANOVA | WT vs. Mecp2 KO | P24-26 | Genotype F(1,96) = 12.44, p = 0.001 |
Fig. 4I | Spatial spread of VSD signal | Unpaired t test | WT vs. Mecp2 KO | P24-26 | p < 0.01 |
Fig. 5B | PV cell density | Unpaired t test | WT vs. Mecp2 KO | P56 | t(10) = 3.67, p = 0.004 |
Fig. 5C | PV fluorescence intensity | Unpaired t test | WT vs. Mecp2 KO | P56 | t(10) = 1.74, p = 0.112 |
Fig. 5D | Relative frequency of PV INs | Mann–Whitney U test | WT vs. Mecp2 KO | P56 | p < 0.001 |
Fig. 5E | Fraction of PV INs | Unpaired t test | WT vs. Mecp2 KO (high PV) | P56 | t(10) = 2.45, p = 0.034 |
| | | WT vs. Mecp2 KO (medium-high PV) | P56 | t(10) = 0.81, p = 0.439 |
| | | WT vs. Mecp2 KO (medium-low PV) | P56 | t(10) = 0.98, p = 0.349 |
| | | WT vs. Mecp2 KO (low PV) | P56 | t(10) = 0.46, p = 0.657 |
Fig. 5G | PV cell density | Unpaired t test | WT vs. Mecp2 KO | P28 | t(6) = 1.43, p = 0.202 |
Fig. 5H | PV fluorescence intensity | Unpaired t test | WT vs. Mecp2 KO | P28 | t(6) = 0.98, p = 0.366 |
Fig. 5I | Relative frequency of PV INs | Mann–Whitney U test | WT vs. Mecp2 KO | P28 | p = 0.023 |
Fig. 5J | Fraction of PV INs | Unpaired t test | WT vs. Mecp2 KO (high PV) | P28 | t(6) = 0.92, p = 0.391 |
| | | WT vs. Mecp2 KO (medium-high PV) | P28 | t(6) = 0.49, p = 0.645 |
| | | WT vs. Mecp2 KO (medium-low PV) | P28 | t(6) = 2.20, p = 0.070 |
| | | WT vs. Mecp2 KO (low PV) | P28 | t(6) = 1.64, p = 0.152 |
Fig. 6A | Rotarod task | Two-way ANOVA | Genotype vs. RR | P56 | RR F(7,112) = 11.62, p < 0.0001 |
| | | | | Genotype F(1,16) = 11.75, p = 0.003 |
| | | | | Interaction F(7,112) =1.12, p = 0.356 |
Fig. 6C | Relative frequency of PV INs | Mann–Whitney U test | WT AC vs. Mecp2 KO-AC | P56 | p = 0.0449 |
| | | WT AC vs. WT RR | P56 | p = 0.0015 |
| | | KO-AC vs. KO-RR | P56 | p < 0.001 |
Fig. 6D | Fraction of PV INs | Two-way ANOVA | Genotype vs. RR (medium-high PV) | P56 | Interaction F(1,18) = 6.19, p = 0.023 |
| Fraction of PV INs | Two-way ANOVA | Genotype vs. RR (high PV) | P56 | Interaction F(1,18) = 10.11, p = 0.005 |
| | | | | Genotype F(1,18) = 20.06, p = 0.0003 |
| | | | | RR F(1,18) = 5.93, p = 0.026 |
Fig. 6D | Correlation between % High PV | Pearson’s r | WT and Mecp2 KO | P56 | r: –0.653, p = 0.006 |
| and RR performance | | | | |
Fig. 7B | VGLUT1 density on PV dendrites | Two-way ANOVA | Genotype vs. RR | P56 | Genotype F(1,16) = 117.91, p < 0.001 |
| | | | | RR F(1,16) = 11.25, p = 0.004 |
| VGLUT1 density on PV soma | Two-way ANOVA | Genotype vs. RR | P56 | Genotype F(1,18) = 37.20, p < 0.001 |
| | | | | RR F(1,18) = 27.33, p < 0.001 |
| VGAT density on PV dendrites | Two-way ANOVA | Genotype vs. RR | P56 | Genotype F(1,16) = 43.89, p < 0.001 |
| | | | | RR F(1,16) = 17.78, p = 0.0007 |
Fig. 8B | Relative frequency of PV INs | Mann–Whitney U test | WT vs. Mecp2 Het | 2 M | p = 0.8219 |
|
Fig. 8E | Relative frequency of PV INs | Mann–Whitney U test | WT vs. Mecp2 Het | 4 M | p = 0.9798 |
Fig. 8F | Fraction of PV INs | Unpaired t test | WT vs. Mecp2 Het (high PV) | 4 M | t(10) = 1.51, p = 0.163 |
| | | WT vs. Mecp2 Het (medium-high PV) | 4 M | t(10) = 3.19, p = 0.009 |
| | | WT vs. Mecp2 Het (medium-low PV) | 4 M | t(10) = 1.03, p = 0.327 |
| | | WT vs. Mecp2 Het (low PV) | 4 M | t(10) = 0.77, p = 0.456 |
Fig. 8H | Relative frequency of PV INs | Mann–Whitney U test | WT vs. Mecp2 Het | 8 M | p < 0.001 |
Fig. 8I | Fraction of PV INs | Unpaired t test | WT vs. Mecp2 Het (high PV) | 8 M | t(10) = 3.16, p = 0.013 |
| | | WT vs. Mecp2 Het (medium-high PV) | 8 M | t(10) = 0.52, p = 0.620 |
| | | WT vs. Mecp2 Het (medium-low PV) | 8 M | t(10) = 4.06, p = 0.004 |
| | | WT vs. Mecp2 Het (low PV) | 8 M | t(10) = 1.40, p = 0.200 |
Fig. 8J | Rotarod task | Two-way ANOVA | Genotype vs. RR | 8 M | RR F(7,176) = 23.60, p < 0.001 |
| | | | | Genotype F(1,176) = 42.81, p < 0.001 |
| | | | | Interaction F(7,176) =0.66, p = 0.706 |
Fig. 8J | Correlation between % HIGH PV and RR performance | Pearson’s r | WT and Mecp2 Het | 8 M | r: –0.481, p = 0.024 |