a | 1F | Normal distribution | Mantel–Cox log rank test; Bonferroni post hoc analysis; K = 6 | Survival postinjection | | |
| | | | | Control vs. P13 ablation DKO | χ2 = 51.18; p < 0.0001 |
| | | | | P13 ablation DKO vs. P23 ablation DKO | χ2 = 25.28; p < 0.0001 |
| | | | | P13 ablation DKO vs. P93 ablation DKO | χ2 = 17.72; p < 0.0001 |
| | | | | Control vs. P23 ablation DKO | x2 = 31.28; p < 0.0001 |
| | | | | P23 ablation vs. P93 ablation | χ2 = 18.68; p < 0.0001 |
| | | | | Control vs. P93 ablation | χ2 = 8.0; p = 0.0047 |
b | 1G | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | P13 ablation: body weight | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p = 0.4746 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.1806 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.0038 |
| | | | | Control 30 dpi vs. DKO 30 dpi | p = 0.0023 |
c | 1H | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | P23 ablation: body weight | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p = 0.0457 |
| | | | | Genotype × timing interaction | p = 0.0002 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.9953 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 1943 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p < 0.0001 |
d | 1I | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | P93 ablation: body weight | | |
| | | | | Effect of genotype | p = 1410 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p = 0.2562 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p > 0.9999 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.9996 |
| | | | | Control 1200 dpi vs. DKO 120 dpi | p = 0.3155 |
e | 2J, AnkG | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P13 ablation: AnkG nodal count | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 10 dpi vs. Ank cKO 10 dpi | p = 0.0694 |
| | | | | Control 20 dpi vs. Ank cKO 20 dpi | p < 0.0001 |
| | | | | Control 30 dpi vs. Ank cKO 30 dpi | p < 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p < 0.0001 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 30 dpi vs. DKO 30 dpi | p < 0.0001 |
| | | | | Ank cKO 10 dpi vs. 20 dpi | p = 0.0010 |
| | | | | Ank cKO 10 dpi vs. 30 dpi | p < 0.0001 |
| | | | | Ank cKO 20 dpi vs. 30 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p > 0.9999 |
| | | | | DKO 10 dpi vs. 30 dpi | p = 0.9997 |
| | | | | DKO 20 dpi vs. 30 dpi | p > 0.9999 |
f | 2J, NF186 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P13 ablation: NF186 nodal count | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 30 dpi vs. Ank cKO 30 dpi | p > 0.9999 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.9984 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.0015 |
| | | | | Control 30 dpi vs. DKO 30 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.0042 |
| | | | | DKO 10 dpi vs. 30 dpi | p < 0.0001 |
| | | | | DKO 20 dpi vs. 30 dpi | p < 0.0001 |
g | 2J′, AnkG | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P13 ablation: AnkG nodal count | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 10 dpi vs. Ank cKO 10 dpi | p < 0.0001 |
| | | | | Control 20 dpi vs. Ank cKO 20 dpi | p < 0.0001 |
| | | | | Control 30 dpi vs. Ank cKO 30 dpi | p < 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p < 0.0001 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 30 dpi vs. DKO 30 dpi | p < 0.0001 |
| | | | | Ank cKO 10 dpi vs. 20 dpi | p = 0.0011 |
| | | | | Ank cKO 10 dpi vs. 30 dpi | p < 0.0001 |
| | | | | Ank cKO 20 dpi vs. 30 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.9973 |
| | | | | DKO 10 dpi vs. 30 dpi | p > 0.9998 |
| | | | | DKO 20 dpi vs. 30 dpi | p = 0.9996 |
h | 2J′, NF186 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P13 ablation: NF186 nodal count | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 30 dpi vs. Ank cKO 30 dpi | p > 0.9999 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.5624 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 30 dpi vs. DKO 30 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.0001 |
| | | | | DKO 10 dpi vs. 30 dpi | p < 0.0001 |
| | | | | DKO 20 dpi vs. 30 dpi | p < 0.0001 |
i | 2K, AnkG | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P23 ablation: AnkG nodal count | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 10 dpi vs. Ank cKO 10 dpi | p = 0.9389 |
| | | | | Control 20 dpi vs. Ank cKO 20 dpi | p < 0.0001 |
| | | | | Control 60 dpi vs. Ank cKO 60 dpi | p < 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p < 0.0001 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p < 0.0001 |
| | | | | Ank cKO 10 dpi vs. 20 dpi | p = 0.0008 |
| | | | | Ank cKO 10 dpi vs. 60 dpi | p < 0.0001 |
| | | | | Ank cKO 20 dpi vs. 60 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p > 0.9999 |
| | | | | DKO 10 dpi vs. 60 dpi | p > 0.9999 |
| | | | | DKO 20 dpi vs. 60 dpi | p = 0.8804 |
j | 2K, NF186 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P23 ablation: NF186 nodal count | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 60 dpi vs. Ank cKO 60 dpi | p > 0.9999 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.9943 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.0031 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.0089 |
| | | | | DKO 10 dpi vs. 60 dpi | p < 0.0001 |
| | | | | DKO 20 dpi vs. 60 dpi | p < 0.0001 |
k | 2K′, AnkG | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P23 ablation: AnkG nodal count | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 10 dpi vs. Ank cKO 10 dpi | p < 0.0001 |
| | | | | Control 20 dpi vs. Ank cKO 20 dpi | p < 0.0001 |
| | | | | Control 60 dpi vs. Ank cKO 60 dpi | p < 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p < 0.0001 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p < 0.0001 |
| | | | | Ank cKO 10 dpi vs. 20 dpi | p < 0.0001 |
| | | | | Ank cKO 10 dpi vs. 60 dpi | p < 0.0001 |
| | | | | Ank cKO 20 dpi vs. 60 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p > 0.9999 |
| | | | | DKO 10 dpi vs. 60 dpi | p > 0.9999 |
| | | | | DKO 20 dpi vs. 60 dpi | p = 0.9991 |
l | 2K′, NF186 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P23 ablation: NF186 nodal count | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 60 dpi vs. Ank cKO 60 dpi | p > 0.9999 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.6324 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.0001 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.0009 |
| | | | | DKO 10 dpi vs. 60 dpi | p < 0.0001 |
| | | | | DKO 20 dpi vs. 60 dpi | p < 0.0001 |
m | 2L, AnkG | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P93 ablation: AnkG nodal count | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p = 0.9562 |
| | | | | Genotype × timing interaction | p = 0.1124 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p < 0.0001 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 120 dpi vs. DKO 120 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.7683 |
| | | | | DKO 10 dpi vs. 120 dpi | p = 0.9502 |
| | | | | DKO 20 dpi vs. 120 dpi | p = 0.9925 |
n | 2L, NF186 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P93 ablation: NF186 nodal count | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.1372 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.0182 |
| | | | | Control 120 dpi vs. DKO 120 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.9704 |
| | | | | DKO 10 dpi vs. 120 dpi | p < 0.0001 |
| | | | | DKO 20 dpi vs. 120 dpi | p < 0.0001 |
o | 2L′, AnkG | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P93 ablation: AnkG nodal count | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p = 0.0083 |
| | | | | Genotype × timing interaction | p = 0.0063 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p < 0.0001 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 120 dpi vs. DKO 120 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.1040 |
| | | | | DKO 10 dpi vs. 120 dpi | p = 0.0010 |
| | | | | DKO 20 dpi vs. 120 dpi | p = 0.2210 |
p | 2L′, NF186 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P93 ablation: NF186 nodal count | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.9167 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.4298 |
| | | | | Control 120 dpi vs. DKO 120 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.9131 |
| | | | | DKO 10 dpi vs. 120 dpi | p < 0.0001 |
| | | | | DKO 20 dpi vs. 120 dpi | p < 0.0001 |
q | 2M, P13 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P13 ablation: NF186 intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p = 0.0001 |
| | | | | Genotype × timing interaction | p = 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.4702 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.0001 |
| | | | | Control 30 dpi vs. DKO 30 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.0125 |
| | | | | DKO 10 dpi vs. 30 dpi | p < 0.0001 |
| | | | | DKO 20 dpi vs. 30 dpi | p = 0.0036 |
r | 2M, P23 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P23 ablation: NF186 intensity | | |
| | | | | Effect of genotype | p = 0.0007 |
| | | | | Effect of timing postinjection | p = 0.0308 |
| | | | | Genotype × timing interaction | p = 0.0308 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.9972 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.2550 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p = 0.0029 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.5495 |
| | | | | DKO 10 dpi vs. 60 dpi | p = 0.0070 |
| | | | | DKO 20 dpi vs. 60 dpi | p = 0.1800 |
s | 2M, P93 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P93 ablation: NF186 intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p > 0.9999 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.2330 |
| | | | | Control 120 dpi vs. DKO 120 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.2696 |
| | | | | DKO 10 dpi vs. 120 dpi | p < 0.0001 |
| | | | | DKO 20 dpi vs. 120 dpi | p = 0.0003 |
t | 2M′, P13 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P13 ablation: NF186 intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p = 0.0003 |
| | | | | Genotype × timing interaction | p = 0.0003 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.9382 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.0971 |
| | | | | Control 30 dpi vs. DKO 30 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.5018 |
| | | | | DKO 10 dpi vs. 30 dpi | p < 0.0001 |
| | | | | DKO 20 dpi vs. 30 dpi | p = 0.0009 |
u | 2M′, P23 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P23 ablation: NF186 intensity | | |
| | | | | Effect of genotype | p = 0.0013 |
| | | | | Effect of timing postinjection | p = 0.0112 |
| | | | | Genotype × timing interaction | p = 0.0113 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p > 0.9999 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.5115 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p = 0.0010 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.6657 |
| | | | | DKO 10 dpi vs. 60 dpi | p = 0.0028 |
| | | | | DKO 20 dpi vs. 60 dpi | p = 0.0329 |
v | 2M′, P93 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P93 ablation: NF186 intensity | | |
| | | | | Effect of genotype | p = 0.0007 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p > 0.9999 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.9996 |
| | | | | Control 120 dpi vs. DKO 120 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.9978 |
| | | | | DKO 10 dpi vs. 120 dpi | p < 0.0001 |
| | | | | DKO 20 dpi vs. 120 dpi | p < 0.0001 |
w | 2Q | Normal distribution | Unpaired, two-tailed t test | SN P13 ablation: relative protein level | | |
| | | | | AnkG level: control vs. Ank cKO | p = 0.0002 |
| | | | | AnkG level: control vs. DKO | p = 0.006 |
| | | | | NF186 level: control vs. Ank cKO | p = 0.9415 |
| | | | | NF186 level: control vs. DKO | p = 0.0062 |
× | 2Q′ | Normal distribution | Unpaired, two-tailed t test | SC P13 ablation: relative protein level | | |
| | | | | AnkG level: control vs. Ank cKO | p = 0.0079 |
| | | | | AnkG level: control vs. DKO | p = 0.0013 |
| | | | | NF186 level: control vs. Ank cKO | p = 0.355 |
| | | | | NF186 level: control vs. DKO | p = 0.0003 |
y | 2R | Normal distribution | Unpaired, two-tailed t test | SN P23 ablation: relative protein level | | |
| | | | | AnkG level: control vs. Ank cKO | p = 0.0404 |
| | | | | AnkG level: control vs. DKO | p = 0.0046 |
| | | | | NF186 level: control vs. Ank cKO | p = 0.3541 |
| | | | | NF186 level: control vs. DKO | p = 0.0249 |
z | 2R′ | Normal distribution | Unpaired, two-tailed t test | SC P23 ablation: relative protein level | | |
| | | | | AnkG level: control vs. Ank cKO | p = 0.0036 |
| | | | | AnkG level: control vs. DKO | p = 0.0016 |
| | | | | NF186 level: control vs. Ank cKO | p = 0.7327 |
| | | | | NF186 level: control vs. DKO | p = 0.0066 |
aa | 2S | Normal distribution | Unpaired, two-tailed t test | SN P93 ablation: relative protein level | | |
| | | | | AnkG level: control vs. DKO | p = 0.0043 |
| | | | | NF186 level: control vs. DKO | p < 0.0001 |
ab | 2S′ | Normal distribution | Unpaired, two-tailed t test | SC P93 ablation: relative protein level | | |
| | | | | AnkG level: control vs. DKO | p = 0.0009 |
| | | | | NF186 level: control vs. DKO | p = 0.0002 |
ac | 3S, P13 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P13 ablation: NaV intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.9992 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 30 dpi vs. DKO 30 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 30 dpi | p < 0.0001 |
| | | | | DKO 20 dpi vs. 30 dpi | p < 0.0001 |
ad | 3S, P23 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P23 ablation: NaV intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p = 0.0002 |
| | | | | Genotype × timing interaction | p = 0.0002 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.9996 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.0003 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.0011 |
| | | | | DKO 10 dpi vs. 60 dpi | p < 0.0001 |
| | | | | DKO 20 dpi vs. 60 dpi | p = 0.93009 |
ae | 3S, P93 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P93 ablation: NaV intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p = 0.0027 |
| | | | | Genotype × timing interaction | p = 0.0027 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.9996 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.0058 |
| | | | | Control 120 dpi vs. DKO 120 dpi | p = 0.0012 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.0032 |
| | | | | DKO 10 dpi vs. 120 dpi | p = 0.0004 |
| | | | | DKO 20 dpi vs. 120 dpi | p = 0.6551 |
af | 3T, P13 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P13 ablation: NaV intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p = 0.3498 |
| | | | | Genotype × timing interaction | p = 0.3510 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.0085 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.0018 |
| | | | | Control 30 dpi vs. DKO 30 dpi | p = 0.0003 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.9713 |
| | | | | DKO 10 dpi vs. 30 dpi | p = 0.2965 |
| | | | | DKO 20 dpi vs. 30 dpi | p = 0.7138 |
ag | 3T, P23 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P23 ablation: NaV intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p = 0.0451 |
| | | | | Genotype × timing interaction | p = 0.0452 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.4863 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.0089 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p = 0.0004 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.2164 |
| | | | | DKO 10 dpi vs. 60 dpi | p = 0.0152 |
| | | | | DKO 20 dpi vs. 60 dpi | p = 0.8617 |
ah | 3T, P93 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P93 ablation: NaV intensity | | |
| | | | | Effect of genotype | p = 0.0015 |
| | | | | Effect of timing postinjection | p = 0.0108 |
| | | | | Genotype × timing interaction | p = 0.0107 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.9987 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.7937 |
| | | | | Control 120 dpi vs. DKO 120 dpi | p = 0.0025 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.9066 |
| | | | | DKO 10 dpi vs. 120 dpi | p = 0.0026 |
| | | | | DKO 20 dpi vs. 120 dpi | p = 0.0259 |
ai | 3U | Normal distribution | Unpaired, two-tailed t test | SC- NaV: relative protein level | | |
| | | | | Control vs. P13 ablation DKO | p = 0.8532 |
| | | | | Control vs. P23 ablation DKO | p = 0.927 |
| | | | | Control vs. P93 ablation | p = 0.98 |
aj | 4S, P13 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P13 ablation: BIV intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p = 0.0169 |
| | | | | Genotype × timing interaction | p = 0.0170 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.1170 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.0017 |
| | | | | Control 30 dpi vs. DKO 30 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.1209 |
| | | | | DKO 10 dpi vs. 30 dpi | p = 0.0036 |
| | | | | DKO 20 dpi vs. 30 dpi | p = 0.6801 |
ak | 4S, P23 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P23 ablation: BIV intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p = 0.0423 |
| | | | | Genotype × timing interaction | p = 0.0425 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.7035 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.1771 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p = 0.0006 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.9089 |
| | | | | DKO 10 dpi vs. 60 dpi | p = 0.0215 |
| | | | | DKO 20 dpi vs. 60 dpi | p = 0.1587 |
al | 4S, P93 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P93 ablation: BIV intensity | | |
| | | | | Effect of genotype | p = 0.0006 |
| | | | | Effect of timing postinjection | p = 0.0394 |
| | | | | Genotype × timing interaction | p = 0.0394 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.9642 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.2846 |
| | | | | Control 120 dpi vs. DKO 120 dpi | p = 0.0040 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.6927 |
| | | | | DKO 10 dpi vs. 120 dpi | p = 0.0147 |
| | | | | DKO 20 dpi vs. 120 dpi | p = 0.1642 |
am | 4T, P13 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P13 ablation: BIV intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p = 0.2569 |
| | | | | Genotype × timing interaction | p = 0.2569 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.0004 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 30 dpi vs. DKO 30 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.9939 |
| | | | | DKO 10 dpi vs. 30 dpi | p = 0.2390 |
| | | | | DKO 20 dpi vs. 30 dpi | p = 0.5023 |
an | 4T, P23 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P23 ablation: BIV intensity | | |
| | | | | Effect of genotype | p = 0.0003 |
| | | | | Effect of timing postinjection | p = 0.1459 |
| | | | | Genotype × timing interaction | p = 0.1459 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.8248 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.1930 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p = 0.0043 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.8728 |
| | | | | DKO 10 dpi vs. 60 dpi | p = 0.0925 |
| | | | | DKO 20 dpi vs. 60 dpi | p = 0.5341 |
ao | 4T, P93 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P93 ablation: BIV intensity | | |
| | | | | Effect of genotype | p = 0.0198 |
| | | | | Effect of timing postinjection | p = 0.0050 |
| | | | | Genotype × timing interaction | p = 0.0050 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p > 0.9999 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.9978 |
| | | | | Control 120 dpi vs. DKO 120 dpi | p = 0.0042 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.9877 |
| | | | | DKO 10 dpi vs. 120 dpi | p = 0.0031 |
| | | | | DKO 20 dpi vs. 120 dpi | p = 0.0019 |
ap | 4U | Normal distribution | Unpaired, two-tailed t test | SC- BIV: relative protein level | | |
| | | | | Control vs. P13 ablation DKO | p = 0.7971 |
| | | | | Control vs. P23 ablation DKO | p = 0.9601 |
| | | | | Control vs. P93 ablation | p = 0.8546 |
aq | 5S, P13 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P13 ablation: AnkR intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p = 0.0001 |
| | | | | Genotype × timing interaction | p = 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.0005 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 30 dpi vs. DKO 30 dpi | p > 0.9999 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.0926 |
| | | | | DKO 10 dpi vs. 30 dpi | p = 0.0009 |
| | | | | DKO 20 dpi vs. 30 dpi | p < 0.0001 |
ar | 5S, P23 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P23 ablation: AnkR intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p < 0.0001 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p = 0.8245 |
| | | | | DKO 10 dpi vs. 20 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 60 dpi | p < 0.0001 |
| | | | | DKO 20 dpi vs. 60 dpi | p < 0.0001 |
as | 5S, P93 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SN P93 ablation: AnkR intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.0008 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 120 dpi vs. DKO 120 dpi | p = 0.1776 |
| | | | | DKO 10 dpi vs. 20 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 120 dpi | p < 0.0001 |
| | | | | DKO 20 dpi vs. 120 dpi | p < 0.0001 |
at | 5T, P13 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P13 ablation: AnkR intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0002 |
| | | | | Genotype × timing interaction | p < 0.0003 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.3295 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 30 dpi vs. DKO 30 dpi | p = 0.9979 |
| | | | | DKO 10 dpi vs. 20 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 30 dpi | p = 0.4570 |
| | | | | DKO 20 dpi vs. 30 dpi | p < 0.0001 |
au | 5T, P23 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P23 ablation: AnkR intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.8577 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p > 0.9999 |
| | | | | DKO 10 dpi vs. 20 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 60 dpi | p = 0.8179 |
| | | | | DKO 20 dpi vs. 60 dpi | p < 0.0001 |
av | 5T, P93 | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | SC P93 ablation: AnkR intensity | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.8502 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 120 dpi vs. DKO 120 dpi | p = 0.4611 |
| | | | | DKO 10 dpi vs. 20 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 120 dpi | p = 0.9796 |
| | | | | DKO 20 dpi vs. 120 dpi | p < 0.0001 |
aw | 5U | Normal distribution | Unpaired, two-tailed t test | SC- AnkR: relative protein level | | |
| | | | | Control vs. P13 ablation DKO | p = 0.9677 |
| | | | | Control vs. P23 ablation DKO | p = 0.4293 |
| | | | | Control vs. P93 ablation | p = 0.2763 |
ax | 6B | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | P13 ablation: NCV | | |
| | | | | Effect of genotype | p = 0.0927 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p < 0.0001 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.0005 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p < 0.0001 |
| | | | | Control 30 dpi vs. DKO 30 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.7586 |
| | | | | DKO 10 dpi vs. 30 dpi | p = 0.2018 |
| | | | | DKO 20 dpi vs. 30 dpi | p = 0.9264 |
ay | 6C | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | P13 ablation: Notch Amp | | |
| | | | | Effect of genotype | p = 0.0006 |
| | | | | Effect of timing postinjection | p < 0.0001 |
| | | | | Genotype × timing interaction | p = 0.0016 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.9992 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.3675 |
| | | | | Control 30 dpi vs. DKO 30 dpi | p < 0.0001 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.7221 |
| | | | | DKO 10 dpi vs. 30 dpi | p = 0.9993 |
| | | | | DKO 20 dpi vs. 30 dpi | p = 0.4799 |
az | 6E | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | P23 ablation: NCV | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p = 0.0428 |
| | | | | Genotype × timing interaction | p = 0.0171 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p > 0.9999 |
| | | | | Control 20 dpi vs. DKO 20 dpi | 0.0021 |
| | | | | Control 60 dpi vs. DKO 60 dpi | 0.0004 |
| | | | | DKO 10 dpi vs. 20 dpi | p > 0.9999 |
| | | | | DKO 10 dpi vs. 60 dpi | p = 0.9991 |
| | | | | DKO 20 dpi vs. 60 dpi | p = 0.9998 |
ba | 6F | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | P23 ablation: Notch Amp | | |
| | | | | Effect of genotype | p = 0.0007 |
| | | | | Effect of timing postinjection | p = 0.5107 |
| | | | | Genotype × timing interaction | p = 0.4310 |
| | | | | Control 10 dpi vs. DKO 10 dpi | p = 0.9582 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.0492 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p = 0.034 |
| | | | | DKO 10 dpi vs. 20 dpi | p = 0.6092 |
| | | | | DKO 10 dpi vs. 60 dpi | p = 0.8662 |
| | | | | DKO 20 dpi vs. 60 dpi | p = 0.9906 |
bb | 6H | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | P93 ablation: NCV | | |
| | | | | Effect of genotype | p < 0.0001 |
| | | | | Effect of timing postinjection | p = 0.9269 |
| | | | | Genotype × timing interaction | p = 0.0770 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p = 0.8318 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p = 0.0002 |
| | | | | Control 120 dpi vs. DKO 120 dpi | p = 0.0644 |
| | | | | DKO 20 dpi vs. 60 dpi | p = 0.9163 |
| | | | | DKO 20 dpi vs. 120 dpi | p = 0.4341 |
| | | | | DKO 60 dpi vs. 120 dpi | p = 0.9652 |
bc | 6I | Normal distribution | Two-way ANOVA; Tukey post hoc analysis | P93 ablation: Notch Amp | | |
| | | | | Effect of genotype | p = 0.0213 |
| | | | | Effect of timing postinjection | p = 0.0088 |
| | | | | Genotype × timing interaction | p = 0.0174 |
| | | | | Control 20 dpi vs. DKO 20 dpi | p > 0.9999 |
| | | | | Control 60 dpi vs. DKO 60 dpi | p = 0.0713 |
| | | | | Control 120 dpi vs. DKO 120 dpi | p = 0.0041 |
| | | | | DKO 20 dpi vs. 60 dpi | p > 0.9999 |
| | | | | DKO 20 dpi vs. 120 dpi | p = 0.3463 |
| | | | | DKO 60 dpi vs. 120 dpi | p = 0.4148 |